Maternal and perinatal outcomes after fresh versus frozen embryo transfer-what is the risk-benefit ratio?

Siladitya Bhattacharya*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

12 Citations (Scopus)

Abstract

Fresh ET has been the conventional strategy in IVF, but there is a growing opinion suggesting that its maternal and perinatal outcomes can be enhanced by a policy of elective freezing of embryos, followed by transfer at a later date. Available studies suggest a number of improved maternal and perinatal outcomes after frozen ET, although there is also a suggestion of large for gestational age babies associated with this strategy. The observational nature of the available data limit our confidence in the results of available studies. A genuinely unbiased estimate of the advantages of a policy of elective ET can only be confirmed by a definitive randomized controlled trial with an adequate length of follow-up of the offspring. (C)2016 by American Society for Reproductive Medicine.

Original languageEnglish
Pages (from-to)241-243
Number of pages3
JournalFertility and Sterility
Volume106
Issue number2
Early online date13 Jul 2016
DOIs
Publication statusPublished - Aug 2016

Keywords

  • frozen embryo transfer
  • perinatal
  • maternal
  • outcomes
  • assisted reproductive technology
  • metaanalysis
  • fertilization
  • IVF
  • protocol
  • cycles
  • born

Cite this

Maternal and perinatal outcomes after fresh versus frozen embryo transfer-what is the risk-benefit ratio? / Bhattacharya, Siladitya.

In: Fertility and Sterility, Vol. 106, No. 2, 08.2016, p. 241-243.

Research output: Contribution to journalComment/debate

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AB - Fresh ET has been the conventional strategy in IVF, but there is a growing opinion suggesting that its maternal and perinatal outcomes can be enhanced by a policy of elective freezing of embryos, followed by transfer at a later date. Available studies suggest a number of improved maternal and perinatal outcomes after frozen ET, although there is also a suggestion of large for gestational age babies associated with this strategy. The observational nature of the available data limit our confidence in the results of available studies. A genuinely unbiased estimate of the advantages of a policy of elective ET can only be confirmed by a definitive randomized controlled trial with an adequate length of follow-up of the offspring. (C)2016 by American Society for Reproductive Medicine.

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