Abstract
Are maternal vitamin D and E intakes during pregnancy associated with asthma in 10-year-old children? In a longitudinal study of 1924 children born to women recruited during pregnancy, maternal vitamin D intake during pregnancy was assessed by the Food Frequency Questionnaire (FFQ) and vitamin E by FFQ and plasma α-tocopherol; respiratory questionnaires were completed for the 10-year-old children. Their treatment for asthma was also ascertained using administrative data. Longitudinal analyses included data collected at 1, 2, 5 and 10 years. Symptom data were available for 934 (49%) children and use of asthma medication for 1748 (91%). In the children maternal vitamin D intake during pregnancy was negatively associated with doctor-diagnosed asthma at 10 years of age (OR per intake quintile 0.86, 95% CI 0.74-0.99) and over the first 10 years (hazard ratio 0.90, 95% CI 0.81-1.00). Maternal plasma α-tocopherol at 11 weeks gestation was negatively associated with children receiving asthma treatment (OR per standard deviation increase 0.52, 95% CI 0.31-0.87). Maternal vitamin E intake was negatively associated with doctor-diagnosed asthma (OR 0.89, 95% CI 0.81-0.99) in the first 10 years. Low maternal vitamin D and E intakes during pregnancy are associated with increased risk of children developing asthma in the first 10 years of life. These associations may have significant public health implications.
Original language | English |
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Pages (from-to) | 1027-1036 |
Number of pages | 10 |
Journal | European Respiratory Journal |
Volume | 45 |
Issue number | 4 |
Early online date | 30 Oct 2014 |
DOIs | |
Publication status | Published - Apr 2015 |
Bibliographical note
©ERS.This article has supplementary material available from erj.ersjournals.com
Received: June 04 2014 | Accepted after revision: Sept 25 2014 | First published online: Oct 30 2014
Support statement: The 10-year follow-up of this cohort was funded by the UK Medical Research Council (grant
number: 80219), the recruitment and follow-up at 1, 2 and 5 years was funded by Asthma UK (grant numbers: 00/011
and 02/017).
Conflict of interest: Disclosures can be found alongside the online version of this article at erj.ersjournals.com
Keywords
- Vitamin D intake
- Vitamin E intake
- Pregnancy
- Asthma
- Children
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Leone Craig
Person: Academic
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Stephen Turner
- FLAMINGO Study
- School of Medicine, Medical Sciences & Nutrition, Applied Health Sciences - Honorary Professor
Person: Honorary