Maternal vitamin D and E intakes in pregnancy and asthma to age 15 years: A cohort study

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Abstract

This study investigated whether the previously reported associations in this birth cohort between maternal vitamin D and E intakes during pregnancy and childhood wheeze/asthma outcomes at age 5 and 10 years are still evident at age 15 years. In a prospective study of 1924 children recruited in utero, maternal vitamin D and E intakes during pregnancy were assessed by food frequency questionnaire and the children completed raespiratory questionnaire at age 15 years. Treatment for asthma at age 15 was also ascertained using healthcare data. Maternal vitamin D and E intakes were also related to combined childhood asthma data collected at 1, 2, 5, 10, and 15 years of age. Symptom data were available for 747 (39%) 15‐year olds and healthcare data for 1689 (88%). There were no associations between maternal vitamin D and E intakes and childhood wheeze and asthma at age 15. Analysis of combined data collected between 1 and 15 years of age demonstrated that higher maternal vitamin D and E intakes during pregnancy were associated with a reduced likelihood of being diagnosed with asthma in the first 15 years: hazard ratio (95%CI) per quartile increase in vitamin intake of 0.87 (0.78,0.98) and 0.88 (0.78,0.98), respectively. Lower maternal vitamin D and E intakes during pregnancy are associated with increased risk of children wheezing and being diagnosed with asthma in the first 10 years but not after puberty, suggesting that post‐natal exposures predominate in the etiology of incident asthma as children transition through puberty into adulthood.
Original languageEnglish
Pages (from-to)11-19
Number of pages9
JournalPediatric Pulmonology
Volume54
Issue number1
Early online date13 Nov 2018
DOIs
Publication statusPublished - 1 Jan 2019

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Vitamin E
Vitamin D
Cohort Studies
Asthma
Mothers
Pregnancy
Puberty
Delivery of Health Care
Respiratory Sounds
Vitamins
Parturition
Prospective Studies
Food

Keywords

  • pregnancy
  • vitamin D
  • vitamin E
  • children
  • asthma
  • wheeze

Cite this

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title = "Maternal vitamin D and E intakes in pregnancy and asthma to age 15 years: A cohort study",
abstract = "This study investigated whether the previously reported associations in this birth cohort between maternal vitamin D and E intakes during pregnancy and childhood wheeze/asthma outcomes at age 5 and 10 years are still evident at age 15 years. In a prospective study of 1924 children recruited in utero, maternal vitamin D and E intakes during pregnancy were assessed by food frequency questionnaire and the children completed raespiratory questionnaire at age 15 years. Treatment for asthma at age 15 was also ascertained using healthcare data. Maternal vitamin D and E intakes were also related to combined childhood asthma data collected at 1, 2, 5, 10, and 15 years of age. Symptom data were available for 747 (39{\%}) 15‐year olds and healthcare data for 1689 (88{\%}). There were no associations between maternal vitamin D and E intakes and childhood wheeze and asthma at age 15. Analysis of combined data collected between 1 and 15 years of age demonstrated that higher maternal vitamin D and E intakes during pregnancy were associated with a reduced likelihood of being diagnosed with asthma in the first 15 years: hazard ratio (95{\%}CI) per quartile increase in vitamin intake of 0.87 (0.78,0.98) and 0.88 (0.78,0.98), respectively. Lower maternal vitamin D and E intakes during pregnancy are associated with increased risk of children wheezing and being diagnosed with asthma in the first 10 years but not after puberty, suggesting that post‐natal exposures predominate in the etiology of incident asthma as children transition through puberty into adulthood.",
keywords = "pregnancy, vitamin D, vitamin E, children, asthma, wheeze",
author = "Graham Devereux and Leone Craig and Anthony Seaton and Steve Turner",
note = "ACKNOWLEDGMENTS The authors are extremely grateful for the enthusiasm and time given by the parents and participants in this birth cohort study. The 10‐ and 15‐year follow‐ups of this cohort were funded by the Medical Research Council (grants 80219, MR/K001035/1), the recruitment and follow‐up at 1, 2, and 5 years was funded by Asthma UK (grants 00/011, 02/017).",
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AU - Devereux, Graham

AU - Craig, Leone

AU - Seaton, Anthony

AU - Turner, Steve

N1 - ACKNOWLEDGMENTS The authors are extremely grateful for the enthusiasm and time given by the parents and participants in this birth cohort study. The 10‐ and 15‐year follow‐ups of this cohort were funded by the Medical Research Council (grants 80219, MR/K001035/1), the recruitment and follow‐up at 1, 2, and 5 years was funded by Asthma UK (grants 00/011, 02/017).

PY - 2019/1/1

Y1 - 2019/1/1

N2 - This study investigated whether the previously reported associations in this birth cohort between maternal vitamin D and E intakes during pregnancy and childhood wheeze/asthma outcomes at age 5 and 10 years are still evident at age 15 years. In a prospective study of 1924 children recruited in utero, maternal vitamin D and E intakes during pregnancy were assessed by food frequency questionnaire and the children completed raespiratory questionnaire at age 15 years. Treatment for asthma at age 15 was also ascertained using healthcare data. Maternal vitamin D and E intakes were also related to combined childhood asthma data collected at 1, 2, 5, 10, and 15 years of age. Symptom data were available for 747 (39%) 15‐year olds and healthcare data for 1689 (88%). There were no associations between maternal vitamin D and E intakes and childhood wheeze and asthma at age 15. Analysis of combined data collected between 1 and 15 years of age demonstrated that higher maternal vitamin D and E intakes during pregnancy were associated with a reduced likelihood of being diagnosed with asthma in the first 15 years: hazard ratio (95%CI) per quartile increase in vitamin intake of 0.87 (0.78,0.98) and 0.88 (0.78,0.98), respectively. Lower maternal vitamin D and E intakes during pregnancy are associated with increased risk of children wheezing and being diagnosed with asthma in the first 10 years but not after puberty, suggesting that post‐natal exposures predominate in the etiology of incident asthma as children transition through puberty into adulthood.

AB - This study investigated whether the previously reported associations in this birth cohort between maternal vitamin D and E intakes during pregnancy and childhood wheeze/asthma outcomes at age 5 and 10 years are still evident at age 15 years. In a prospective study of 1924 children recruited in utero, maternal vitamin D and E intakes during pregnancy were assessed by food frequency questionnaire and the children completed raespiratory questionnaire at age 15 years. Treatment for asthma at age 15 was also ascertained using healthcare data. Maternal vitamin D and E intakes were also related to combined childhood asthma data collected at 1, 2, 5, 10, and 15 years of age. Symptom data were available for 747 (39%) 15‐year olds and healthcare data for 1689 (88%). There were no associations between maternal vitamin D and E intakes and childhood wheeze and asthma at age 15. Analysis of combined data collected between 1 and 15 years of age demonstrated that higher maternal vitamin D and E intakes during pregnancy were associated with a reduced likelihood of being diagnosed with asthma in the first 15 years: hazard ratio (95%CI) per quartile increase in vitamin intake of 0.87 (0.78,0.98) and 0.88 (0.78,0.98), respectively. Lower maternal vitamin D and E intakes during pregnancy are associated with increased risk of children wheezing and being diagnosed with asthma in the first 10 years but not after puberty, suggesting that post‐natal exposures predominate in the etiology of incident asthma as children transition through puberty into adulthood.

KW - pregnancy

KW - vitamin D

KW - vitamin E

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KW - wheeze

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U2 - 10.1002/ppul.24184

DO - 10.1002/ppul.24184

M3 - Article

VL - 54

SP - 11

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JO - Pediatric Pulmonology

JF - Pediatric Pulmonology

SN - 8755-6863

IS - 1

ER -