Maternal vitamin D intake during pregnancy and early childhood wheezing

Graham Devereux, Augusto A. Litonjua, Stephen W Turner, Leone CA Craig, Geraldine McNeill, Sheelagh Martindale, Peter J Helms, Anthony Seaton, Scott T. Weiss

Research output: Contribution to journalArticle

437 Citations (Scopus)

Abstract

Background: Maternal intake of vitamin D in pregnancy is a potentially modifiable but understudied risk factor for the development of asthma in children.

Objective: We investigated whether maternal vitamin D intake in pregnancy is associated with decreased risks of wheezing symptoms in young children.

Design: Subjects were from a birth cohort recruited in utero with the primary objective of identifying associations between maternal diet during pregnancy and asthma and allergies in children. A random sample of 2000 healthy pregnant women was recruited while attending antenatal clinics at the Aberdeen Maternity Hospital, Scotland, at approximate to 12 wk gestation. Maternal vitamin D intake was ascertained from a food-frequency questionnaire completed at 32 wk of gestation. The main outcome measures were wheezing symptoms, spirometry, bronchodilator response, atopic sensitization, and exhaled nitric oxide at 5 y.

Results: Respiratory details through 5 y and maternal food-frequency-questionnaire data were available for 1212 children. In models adjusted for potential confounders, including the children's vitamin D intake, a comparison of the highest and lowest quintiles of maternal total vitamin D intake conferred lower risks for ever wheeze [odds ratio (OR): 0.48; 95% CI: 0.25, 0.91], wheeze in the previous year(OR: 0.35; 95% CI: 0.15, 0.83), and persistent wheeze (OR: 0.33; 95%CI: 0.11, 0.98) in 5-y-old children. In addition, lower maternal total vitamin D intakes in pregnancy were also associated with decreased bronchodilator response (P = 0.04). No associations were observed between maternal vitamin D intakes and spirometry or exhaled nitric oxide concentrations.

Conclusion: Increasing maternal vitamin D intakes during pregnancy may decrease the risk of wheeze symptoms in early childhood.

Original languageEnglish
Pages (from-to)853-859
Number of pages7
JournalThe American Journal of Clinical Nutrition
Volume85
Issue number3
Publication statusPublished - Mar 2007

Keywords

  • vitamin D intake
  • pregnancy
  • wheezing
  • asthma
  • D-receptor gene
  • T-cells
  • lung-function
  • 1,25-dihydroxyvitamin D-3
  • antioxidant intake
  • ige production
  • birth-cohort
  • 1st year
  • children

Cite this

Maternal vitamin D intake during pregnancy and early childhood wheezing. / Devereux, Graham; Litonjua, Augusto A.; Turner, Stephen W; Craig, Leone CA; McNeill, Geraldine; Martindale, Sheelagh; Helms, Peter J; Seaton, Anthony; Weiss, Scott T.

In: The American Journal of Clinical Nutrition, Vol. 85, No. 3, 03.2007, p. 853-859.

Research output: Contribution to journalArticle

Devereux, Graham ; Litonjua, Augusto A. ; Turner, Stephen W ; Craig, Leone CA ; McNeill, Geraldine ; Martindale, Sheelagh ; Helms, Peter J ; Seaton, Anthony ; Weiss, Scott T. / Maternal vitamin D intake during pregnancy and early childhood wheezing. In: The American Journal of Clinical Nutrition. 2007 ; Vol. 85, No. 3. pp. 853-859.
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abstract = "Background: Maternal intake of vitamin D in pregnancy is a potentially modifiable but understudied risk factor for the development of asthma in children.Objective: We investigated whether maternal vitamin D intake in pregnancy is associated with decreased risks of wheezing symptoms in young children.Design: Subjects were from a birth cohort recruited in utero with the primary objective of identifying associations between maternal diet during pregnancy and asthma and allergies in children. A random sample of 2000 healthy pregnant women was recruited while attending antenatal clinics at the Aberdeen Maternity Hospital, Scotland, at approximate to 12 wk gestation. Maternal vitamin D intake was ascertained from a food-frequency questionnaire completed at 32 wk of gestation. The main outcome measures were wheezing symptoms, spirometry, bronchodilator response, atopic sensitization, and exhaled nitric oxide at 5 y.Results: Respiratory details through 5 y and maternal food-frequency-questionnaire data were available for 1212 children. In models adjusted for potential confounders, including the children's vitamin D intake, a comparison of the highest and lowest quintiles of maternal total vitamin D intake conferred lower risks for ever wheeze [odds ratio (OR): 0.48; 95{\%} CI: 0.25, 0.91], wheeze in the previous year(OR: 0.35; 95{\%} CI: 0.15, 0.83), and persistent wheeze (OR: 0.33; 95{\%}CI: 0.11, 0.98) in 5-y-old children. In addition, lower maternal total vitamin D intakes in pregnancy were also associated with decreased bronchodilator response (P = 0.04). No associations were observed between maternal vitamin D intakes and spirometry or exhaled nitric oxide concentrations.Conclusion: Increasing maternal vitamin D intakes during pregnancy may decrease the risk of wheeze symptoms in early childhood.",
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T1 - Maternal vitamin D intake during pregnancy and early childhood wheezing

AU - Devereux, Graham

AU - Litonjua, Augusto A.

AU - Turner, Stephen W

AU - Craig, Leone CA

AU - McNeill, Geraldine

AU - Martindale, Sheelagh

AU - Helms, Peter J

AU - Seaton, Anthony

AU - Weiss, Scott T.

PY - 2007/3

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N2 - Background: Maternal intake of vitamin D in pregnancy is a potentially modifiable but understudied risk factor for the development of asthma in children.Objective: We investigated whether maternal vitamin D intake in pregnancy is associated with decreased risks of wheezing symptoms in young children.Design: Subjects were from a birth cohort recruited in utero with the primary objective of identifying associations between maternal diet during pregnancy and asthma and allergies in children. A random sample of 2000 healthy pregnant women was recruited while attending antenatal clinics at the Aberdeen Maternity Hospital, Scotland, at approximate to 12 wk gestation. Maternal vitamin D intake was ascertained from a food-frequency questionnaire completed at 32 wk of gestation. The main outcome measures were wheezing symptoms, spirometry, bronchodilator response, atopic sensitization, and exhaled nitric oxide at 5 y.Results: Respiratory details through 5 y and maternal food-frequency-questionnaire data were available for 1212 children. In models adjusted for potential confounders, including the children's vitamin D intake, a comparison of the highest and lowest quintiles of maternal total vitamin D intake conferred lower risks for ever wheeze [odds ratio (OR): 0.48; 95% CI: 0.25, 0.91], wheeze in the previous year(OR: 0.35; 95% CI: 0.15, 0.83), and persistent wheeze (OR: 0.33; 95%CI: 0.11, 0.98) in 5-y-old children. In addition, lower maternal total vitamin D intakes in pregnancy were also associated with decreased bronchodilator response (P = 0.04). No associations were observed between maternal vitamin D intakes and spirometry or exhaled nitric oxide concentrations.Conclusion: Increasing maternal vitamin D intakes during pregnancy may decrease the risk of wheeze symptoms in early childhood.

AB - Background: Maternal intake of vitamin D in pregnancy is a potentially modifiable but understudied risk factor for the development of asthma in children.Objective: We investigated whether maternal vitamin D intake in pregnancy is associated with decreased risks of wheezing symptoms in young children.Design: Subjects were from a birth cohort recruited in utero with the primary objective of identifying associations between maternal diet during pregnancy and asthma and allergies in children. A random sample of 2000 healthy pregnant women was recruited while attending antenatal clinics at the Aberdeen Maternity Hospital, Scotland, at approximate to 12 wk gestation. Maternal vitamin D intake was ascertained from a food-frequency questionnaire completed at 32 wk of gestation. The main outcome measures were wheezing symptoms, spirometry, bronchodilator response, atopic sensitization, and exhaled nitric oxide at 5 y.Results: Respiratory details through 5 y and maternal food-frequency-questionnaire data were available for 1212 children. In models adjusted for potential confounders, including the children's vitamin D intake, a comparison of the highest and lowest quintiles of maternal total vitamin D intake conferred lower risks for ever wheeze [odds ratio (OR): 0.48; 95% CI: 0.25, 0.91], wheeze in the previous year(OR: 0.35; 95% CI: 0.15, 0.83), and persistent wheeze (OR: 0.33; 95%CI: 0.11, 0.98) in 5-y-old children. In addition, lower maternal total vitamin D intakes in pregnancy were also associated with decreased bronchodilator response (P = 0.04). No associations were observed between maternal vitamin D intakes and spirometry or exhaled nitric oxide concentrations.Conclusion: Increasing maternal vitamin D intakes during pregnancy may decrease the risk of wheeze symptoms in early childhood.

KW - vitamin D intake

KW - pregnancy

KW - wheezing

KW - asthma

KW - D-receptor gene

KW - T-cells

KW - lung-function

KW - 1,25-dihydroxyvitamin D-3

KW - antioxidant intake

KW - ige production

KW - birth-cohort

KW - 1st year

KW - children

M3 - Article

VL - 85

SP - 853

EP - 859

JO - The American Journal of Clinical Nutrition

JF - The American Journal of Clinical Nutrition

SN - 0002-9165

IS - 3

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