Mathematically guided approaches to distinguish models of periodic patterning

Tom W. Hiscock, Sean G. Megason*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)


How periodic patterns are generatedisan open question. A number of mechanisms have been proposed – most famously, Turing’s reaction-diffusion model. However, many theoretical and experimental studies focus on the Turing mechanism while ignoring other possible mechanisms. Here, we use a general model of periodic patterning to show that different types of mechanism (molecular, cellular, mechanical) can generate qualitatively similar final patterns. Observation of final patterns is therefore not sufficient to favour one mechanism over others. However, we propose that a mathematical approach can help to guide the design of experiments that can distinguish between different mechanisms, and illustrate the potential value of this approach with specific biological examples.

Original languageEnglish
Pages (from-to)409-419
Number of pages11
JournalDevelopment (Cambridge)
Issue number3
Publication statusPublished - 1 Feb 2015


  • Mathematical biology
  • Pattern formation
  • Periodic patterning
  • Pigment pattern
  • Reaction-diffusion
  • Turing


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