Matrix metalloproteinases: molecular aspects of their roles in tumour invasion and metastasis

Stephanie Curran, Graeme Ian Murray

Research output: Contribution to journalArticle

482 Citations (Scopus)

Abstract

The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes, whose physiological functions include tissue remodelling and embryogenesis. Thc importance of this group of proteins in the processes of tumour invasion and metastasis is now widely acknowledged, and has led to the search for MMP inhibitors for use as anticancer treatments in a clinical setting. This review aims to bring the reader up-to-date with current research relating to MMPs, with particular emphasis on emerging mechanisms of regulation of these enzymes, and their interaction with cell adhesion molecules. The therapeutic inhibition of MMPs will also be discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)1621-1630
Number of pages10
JournalEuropean Journal of Cancer
Volume36
Publication statusPublished - 2000

Keywords

  • matrix metalloproteinase
  • tumour
  • pathology
  • gene regulation
  • GELATINASE-B SECRETION
  • colon cancer cells
  • colorectal cancer
  • tissue inhibitors
  • gastric cancer
  • INTEGRIN ALPHA-V-BETA-3
  • STROMELYSIN-1 MMP-3
  • breast carcinoma
  • poor prognosis
  • human melanoma

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