Measurement of body composition changes during weight loss in obese men using multi-frequency bioelectrical impedance analysis and multi-compartment models

Alexandra Johnstone, Peter Faber, Eileen R. Gibney, Gerald Lobley, Richard Stubbs, Mario Siervo*

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: The accurate measurement of changes in body composition is important to assess the contribution of fat and fat free mass to total body mass change as a measure of the effectiveness of weight loss programmes. Bioelectrical impedance spectroscopy (BIS) is a rapid and non-invasive technique which could be applied to assess body composition changes. The aim of the study was to evaluate the accuracy of the BIS for the measurement of fat mass (FM), total body water (TBW) and extracellular water (ECW) changes induced by different degrees of caloric deficit in obese men.

Methods: Three groups of six, obese men participated in either (i) a total fast (for 6 days); (ii) a VLCD (2.5 MJ/day for 3 weeks); or (iii) LCD (5.2 MJ/day for 6 weeks). FM was measured using a 4-compartment (4-C) model. TBW and ECW were determined by dilution methods, respectively. TBW, ECW and FM were also assessed with BIS.

Results: Body weight loss in the fasting group was 6.0 +/- 1.3 kg over 6 days; the VLCD group lost 9.2 +/- 1.2 kg over 21 days and the LCD group lost 12.6 +/- 2.4 kg over 42 days. BIS underestimated FM changes (bias = -3.3 +/- 3.8 kg) and overestimated changes in TBW and ECW by +1.8 +/- 4.8 kg and +2.3 +/- 6.4 kg, respectively. The measurement error was consistently larger in the fasting group and the magnitude of the bias interacted significantly with the rate of weight loss.

Conclusion: Rapid weight loss affects the accuracy of the BIS in detecting changes in body composition. A careful interpretation of the results is needed when sizable changes in body water compartments occurs. (c) 2012 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)E46-E54
Number of pages9
JournalObesity research & clinical practice
Volume8
Issue number1
Early online date5 Sep 2012
DOIs
Publication statusPublished - Feb 2014

Keywords

  • obesity
  • weight loss
  • multi-compartment models
  • dilution methods
  • multi-frequency bioimpedence
  • bioimpedance spectroscopy
  • cell mass
  • fluid
  • water
  • volumes
  • validation
  • dueterium
  • disease
  • plasma
  • women

Cite this

@article{cb509b5bc9914bcabd1d30ccd357b203,
title = "Measurement of body composition changes during weight loss in obese men using multi-frequency bioelectrical impedance analysis and multi-compartment models",
abstract = "Background: The accurate measurement of changes in body composition is important to assess the contribution of fat and fat free mass to total body mass change as a measure of the effectiveness of weight loss programmes. Bioelectrical impedance spectroscopy (BIS) is a rapid and non-invasive technique which could be applied to assess body composition changes. The aim of the study was to evaluate the accuracy of the BIS for the measurement of fat mass (FM), total body water (TBW) and extracellular water (ECW) changes induced by different degrees of caloric deficit in obese men.Methods: Three groups of six, obese men participated in either (i) a total fast (for 6 days); (ii) a VLCD (2.5 MJ/day for 3 weeks); or (iii) LCD (5.2 MJ/day for 6 weeks). FM was measured using a 4-compartment (4-C) model. TBW and ECW were determined by dilution methods, respectively. TBW, ECW and FM were also assessed with BIS.Results: Body weight loss in the fasting group was 6.0 +/- 1.3 kg over 6 days; the VLCD group lost 9.2 +/- 1.2 kg over 21 days and the LCD group lost 12.6 +/- 2.4 kg over 42 days. BIS underestimated FM changes (bias = -3.3 +/- 3.8 kg) and overestimated changes in TBW and ECW by +1.8 +/- 4.8 kg and +2.3 +/- 6.4 kg, respectively. The measurement error was consistently larger in the fasting group and the magnitude of the bias interacted significantly with the rate of weight loss.Conclusion: Rapid weight loss affects the accuracy of the BIS in detecting changes in body composition. A careful interpretation of the results is needed when sizable changes in body water compartments occurs. (c) 2012 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.",
keywords = "obesity, weight loss, multi-compartment models, dilution methods, multi-frequency bioimpedence, bioimpedance spectroscopy, cell mass, fluid, water, volumes, validation, dueterium, disease, plasma, women",
author = "Alexandra Johnstone and Peter Faber and Gibney, {Eileen R.} and Gerald Lobley and Richard Stubbs and Mario Siervo",
note = "Acknowledgements This work was supported by funding from Scottish Executive Environment and Rural Affairs Department (SEERAD) and a grant from Slimming World, Alfreton, UK. Statistical advice was provided by Dr Grietje Holtrop, Biomathematics and Statistics Scotland (BioSS)",
year = "2014",
month = "2",
doi = "10.1016/j.orcp.2012.07.006",
language = "English",
volume = "8",
pages = "E46--E54",
journal = "Obesity research & clinical practice",
issn = "1871-403X",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Measurement of body composition changes during weight loss in obese men using multi-frequency bioelectrical impedance analysis and multi-compartment models

AU - Johnstone, Alexandra

AU - Faber, Peter

AU - Gibney, Eileen R.

AU - Lobley, Gerald

AU - Stubbs, Richard

AU - Siervo, Mario

N1 - Acknowledgements This work was supported by funding from Scottish Executive Environment and Rural Affairs Department (SEERAD) and a grant from Slimming World, Alfreton, UK. Statistical advice was provided by Dr Grietje Holtrop, Biomathematics and Statistics Scotland (BioSS)

PY - 2014/2

Y1 - 2014/2

N2 - Background: The accurate measurement of changes in body composition is important to assess the contribution of fat and fat free mass to total body mass change as a measure of the effectiveness of weight loss programmes. Bioelectrical impedance spectroscopy (BIS) is a rapid and non-invasive technique which could be applied to assess body composition changes. The aim of the study was to evaluate the accuracy of the BIS for the measurement of fat mass (FM), total body water (TBW) and extracellular water (ECW) changes induced by different degrees of caloric deficit in obese men.Methods: Three groups of six, obese men participated in either (i) a total fast (for 6 days); (ii) a VLCD (2.5 MJ/day for 3 weeks); or (iii) LCD (5.2 MJ/day for 6 weeks). FM was measured using a 4-compartment (4-C) model. TBW and ECW were determined by dilution methods, respectively. TBW, ECW and FM were also assessed with BIS.Results: Body weight loss in the fasting group was 6.0 +/- 1.3 kg over 6 days; the VLCD group lost 9.2 +/- 1.2 kg over 21 days and the LCD group lost 12.6 +/- 2.4 kg over 42 days. BIS underestimated FM changes (bias = -3.3 +/- 3.8 kg) and overestimated changes in TBW and ECW by +1.8 +/- 4.8 kg and +2.3 +/- 6.4 kg, respectively. The measurement error was consistently larger in the fasting group and the magnitude of the bias interacted significantly with the rate of weight loss.Conclusion: Rapid weight loss affects the accuracy of the BIS in detecting changes in body composition. A careful interpretation of the results is needed when sizable changes in body water compartments occurs. (c) 2012 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

AB - Background: The accurate measurement of changes in body composition is important to assess the contribution of fat and fat free mass to total body mass change as a measure of the effectiveness of weight loss programmes. Bioelectrical impedance spectroscopy (BIS) is a rapid and non-invasive technique which could be applied to assess body composition changes. The aim of the study was to evaluate the accuracy of the BIS for the measurement of fat mass (FM), total body water (TBW) and extracellular water (ECW) changes induced by different degrees of caloric deficit in obese men.Methods: Three groups of six, obese men participated in either (i) a total fast (for 6 days); (ii) a VLCD (2.5 MJ/day for 3 weeks); or (iii) LCD (5.2 MJ/day for 6 weeks). FM was measured using a 4-compartment (4-C) model. TBW and ECW were determined by dilution methods, respectively. TBW, ECW and FM were also assessed with BIS.Results: Body weight loss in the fasting group was 6.0 +/- 1.3 kg over 6 days; the VLCD group lost 9.2 +/- 1.2 kg over 21 days and the LCD group lost 12.6 +/- 2.4 kg over 42 days. BIS underestimated FM changes (bias = -3.3 +/- 3.8 kg) and overestimated changes in TBW and ECW by +1.8 +/- 4.8 kg and +2.3 +/- 6.4 kg, respectively. The measurement error was consistently larger in the fasting group and the magnitude of the bias interacted significantly with the rate of weight loss.Conclusion: Rapid weight loss affects the accuracy of the BIS in detecting changes in body composition. A careful interpretation of the results is needed when sizable changes in body water compartments occurs. (c) 2012 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

KW - obesity

KW - weight loss

KW - multi-compartment models

KW - dilution methods

KW - multi-frequency bioimpedence

KW - bioimpedance spectroscopy

KW - cell mass

KW - fluid

KW - water

KW - volumes

KW - validation

KW - dueterium

KW - disease

KW - plasma

KW - women

U2 - 10.1016/j.orcp.2012.07.006

DO - 10.1016/j.orcp.2012.07.006

M3 - Article

VL - 8

SP - E46-E54

JO - Obesity research & clinical practice

JF - Obesity research & clinical practice

SN - 1871-403X

IS - 1

ER -