Measurement of changes in opioid receptor binding in vivo during trigeminal neuralgic pain using [11C] diprenorphine and positron emission tomography

A K Jones, N D Kitchen, H Watabe, V J Cunningham, T Jones, S K Luthra, D G Thomas

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

The binding of [11C]diprenorphine to mu, kappa, and delta subsites in cortical and subcortical structures was measured by positron emission tomography in vivo in six patients before and after surgical relief of trigeminal neuralgia pain. The volume of distribution of [11C]diprenorphine binding was significantly increased after thermocoagulation of the relevant trigeminal division in the following areas: prefrontal, insular, perigenual, mid-cingulate and inferior parietal cortices, basal ganglia, and thalamus bilaterally. In addition to the pain relief associated with the surgical procedure, there also was an improvement in anxiety and depression scores. In the context of other studies, these changes in binding most likely resulted from the change in the pain state. The results suggest an increased occupancy by endogenous opioid peptides during trigeminal pain but cannot exclude coexistent down-regulation of binding sites.
Original languageEnglish
Pages (from-to)803-8
Number of pages6
JournalJournal of Cerebral Blood Flow and Metabolism
Volume19
Issue number7
DOIs
Publication statusPublished - 1999

Fingerprint

Diprenorphine
Opioid Receptors
Positron-Emission Tomography
Pain
Trigeminal Neuralgia
Parietal Lobe
Electrocoagulation
Opioid Peptides
Basal Ganglia
Thalamus
Down-Regulation
Anxiety
Binding Sites
Depression

Keywords

  • Aged
  • Carbon Radioisotopes
  • Diprenorphine
  • Humans
  • Male
  • Middle Aged
  • Narcotic Antagonists
  • Radioligand Assay
  • Receptors, Opioid
  • Tomography, Emission-Computed
  • Trigeminal Neuralgia

Cite this

Measurement of changes in opioid receptor binding in vivo during trigeminal neuralgic pain using [11C] diprenorphine and positron emission tomography. / Jones, A K; Kitchen, N D; Watabe, H; Cunningham, V J; Jones, T; Luthra, S K; Thomas, D G.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 19, No. 7, 1999, p. 803-8.

Research output: Contribution to journalArticle

Jones, A K ; Kitchen, N D ; Watabe, H ; Cunningham, V J ; Jones, T ; Luthra, S K ; Thomas, D G. / Measurement of changes in opioid receptor binding in vivo during trigeminal neuralgic pain using [11C] diprenorphine and positron emission tomography. In: Journal of Cerebral Blood Flow and Metabolism. 1999 ; Vol. 19, No. 7. pp. 803-8.
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KW - Aged

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KW - Diprenorphine

KW - Humans

KW - Male

KW - Middle Aged

KW - Narcotic Antagonists

KW - Radioligand Assay

KW - Receptors, Opioid

KW - Tomography, Emission-Computed

KW - Trigeminal Neuralgia

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