Mechanical adaptation of trabecular bone morphology in the mammalian mandible

Peter J. Watson, Laura C. Fitton, Carlos Meloro, Michael J. Fagan, Flora Gröning

Research output: Contribution to journalArticle

3 Downloads (Pure)

Abstract

Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this structural support and is a major cause of tooth loss. However, the functional relationship between alveolar bone remodelling within the molar region and masticatory forces is not well understood. This study investigated this relationship by comparing mammalian species with different diets and functional loading (Felis catus, Cercocebus atys, Homo sapiens, Sus scrofa, Oryctolagus cuniculus, Ovis aries). We performed histomorphometric analyses of trabecular bone morphology (bone volume fraction, trabecular thickness and trabecular spacing) and quantified the variation of bone and tooth root volumes along the tooth row. A principal component analysis and non-parametric MANOVA showed statistically significant differences in trabecular bone morphology between species with contrasting functional loading, but these differences were not seen in sub-adult specimens. Our results support a strong, but complex link between masticatory function and trabecular bone morphology. Further understanding of a potential functional relationship could aid the diagnosis and treatment of mandibular diseases causing alveolar bone resorption, and guide the design and evaluation of dental implants.
Original languageEnglish
Article number7277
JournalScientific Reports
Volume8
DOIs
Publication statusPublished - 8 May 2018

Fingerprint

Mandible
Bite Force
Alveolar Bone Loss
Bone Resorption
Bone and Bones
Mandibular Diseases
Cercocebus atys
Domestic Sheep
Tooth Root
Tooth Loss
Sus scrofa
Dental Implants
Bone Remodeling
Periodontitis
Principal Component Analysis
Osteoporosis
Tooth
Cats
Diet
Rabbits

Keywords

  • biomedical engineering
  • oral anatomy

Cite this

Mechanical adaptation of trabecular bone morphology in the mammalian mandible. / Watson, Peter J.; Fitton, Laura C.; Meloro, Carlos; Fagan, Michael J.; Gröning, Flora.

In: Scientific Reports, Vol. 8, 7277, 08.05.2018.

Research output: Contribution to journalArticle

Watson, Peter J. ; Fitton, Laura C. ; Meloro, Carlos ; Fagan, Michael J. ; Gröning, Flora. / Mechanical adaptation of trabecular bone morphology in the mammalian mandible. In: Scientific Reports. 2018 ; Vol. 8.
@article{ca74d5a19c7d4c0191b151bb6553c142,
title = "Mechanical adaptation of trabecular bone morphology in the mammalian mandible",
abstract = "Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this structural support and is a major cause of tooth loss. However, the functional relationship between alveolar bone remodelling within the molar region and masticatory forces is not well understood. This study investigated this relationship by comparing mammalian species with different diets and functional loading (Felis catus, Cercocebus atys, Homo sapiens, Sus scrofa, Oryctolagus cuniculus, Ovis aries). We performed histomorphometric analyses of trabecular bone morphology (bone volume fraction, trabecular thickness and trabecular spacing) and quantified the variation of bone and tooth root volumes along the tooth row. A principal component analysis and non-parametric MANOVA showed statistically significant differences in trabecular bone morphology between species with contrasting functional loading, but these differences were not seen in sub-adult specimens. Our results support a strong, but complex link between masticatory function and trabecular bone morphology. Further understanding of a potential functional relationship could aid the diagnosis and treatment of mandibular diseases causing alveolar bone resorption, and guide the design and evaluation of dental implants.",
keywords = "biomedical engineering, oral anatomy",
author = "Watson, {Peter J.} and Fitton, {Laura C.} and Carlos Meloro and Fagan, {Michael J.} and Flora Gr{\"o}ning",
note = "Funding statement This research was supported by BBSRC grant (BB/I008462/1) and Marie Curie Actions Integration grant (FP7-PEOPLE PERG7-GA-2010-268430). Acknowledgements The authors would like to Sue Taft (University of Hull) for performing all µCT-scanning, Sue Black (University of Dundee) for providing the human mandibles, Paul O’Higgins (Hull York Medical School) for the mangabey mandibles, and the Institute of Veterinary Science and Nathan Jeffery (both University of Liverpool) for the cat mandibles used in this study.",
year = "2018",
month = "5",
day = "8",
doi = "10.1038/s41598-018-25597-0",
language = "English",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Mechanical adaptation of trabecular bone morphology in the mammalian mandible

AU - Watson, Peter J.

AU - Fitton, Laura C.

AU - Meloro, Carlos

AU - Fagan, Michael J.

AU - Gröning, Flora

N1 - Funding statement This research was supported by BBSRC grant (BB/I008462/1) and Marie Curie Actions Integration grant (FP7-PEOPLE PERG7-GA-2010-268430). Acknowledgements The authors would like to Sue Taft (University of Hull) for performing all µCT-scanning, Sue Black (University of Dundee) for providing the human mandibles, Paul O’Higgins (Hull York Medical School) for the mangabey mandibles, and the Institute of Veterinary Science and Nathan Jeffery (both University of Liverpool) for the cat mandibles used in this study.

PY - 2018/5/8

Y1 - 2018/5/8

N2 - Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this structural support and is a major cause of tooth loss. However, the functional relationship between alveolar bone remodelling within the molar region and masticatory forces is not well understood. This study investigated this relationship by comparing mammalian species with different diets and functional loading (Felis catus, Cercocebus atys, Homo sapiens, Sus scrofa, Oryctolagus cuniculus, Ovis aries). We performed histomorphometric analyses of trabecular bone morphology (bone volume fraction, trabecular thickness and trabecular spacing) and quantified the variation of bone and tooth root volumes along the tooth row. A principal component analysis and non-parametric MANOVA showed statistically significant differences in trabecular bone morphology between species with contrasting functional loading, but these differences were not seen in sub-adult specimens. Our results support a strong, but complex link between masticatory function and trabecular bone morphology. Further understanding of a potential functional relationship could aid the diagnosis and treatment of mandibular diseases causing alveolar bone resorption, and guide the design and evaluation of dental implants.

AB - Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this structural support and is a major cause of tooth loss. However, the functional relationship between alveolar bone remodelling within the molar region and masticatory forces is not well understood. This study investigated this relationship by comparing mammalian species with different diets and functional loading (Felis catus, Cercocebus atys, Homo sapiens, Sus scrofa, Oryctolagus cuniculus, Ovis aries). We performed histomorphometric analyses of trabecular bone morphology (bone volume fraction, trabecular thickness and trabecular spacing) and quantified the variation of bone and tooth root volumes along the tooth row. A principal component analysis and non-parametric MANOVA showed statistically significant differences in trabecular bone morphology between species with contrasting functional loading, but these differences were not seen in sub-adult specimens. Our results support a strong, but complex link between masticatory function and trabecular bone morphology. Further understanding of a potential functional relationship could aid the diagnosis and treatment of mandibular diseases causing alveolar bone resorption, and guide the design and evaluation of dental implants.

KW - biomedical engineering

KW - oral anatomy

U2 - 10.1038/s41598-018-25597-0

DO - 10.1038/s41598-018-25597-0

M3 - Article

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 7277

ER -