Mechanosensitive channels in bacteria: signs of closure?

Ian R. Booth, Michelle D. Edwards, Susan Shirley Black, Ulrike Schumann, Samantha Miller

Research output: Contribution to journalLiterature review

96 Citations (Scopus)

Abstract

Bacterial mechanosensitive channels are activated by increases in tension in the lipid bilayer of the cytoplasmic membrane, where they transiently create large pores in a controlled manner. Mechanosensitive channel research has benefited from advances in electrophysiology, genomics and molecular genetics as well as from the application of biophysical techniques. Most recently, new analytical methods have been used to complement existing knowledge and generate insights into the molecular interactions that take place between mechanosensitive channel proteins and the surrounding membrane lipids. This article reviews the latest developments.

Original languageEnglish
Pages (from-to)431-440
Number of pages10
JournalNature Reviews Microbiology
Volume5
Issue number6
DOIs
Publication statusPublished - Jun 2007

Keywords

  • of-function mutations
  • escherichia-coli-cells
  • large-conductance
  • membrane-protein
  • ion-channel
  • gating mechanism
  • functional reconstitution
  • acetylcholine-receptor
  • physical principles
  • osmotic downshock

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