Melatonin receptors are present in non-optic regions of the brain of a deep-sea fish living in the absence of solar light

A. Smith*, V. L. Trudeau, L. M. Williams, M. G. Martinoli, I. G. Priede

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Pineal melatonin hormonally transduces photoperiod to influence daily and seasonal cycles in most vertebrates. Evidence of melatonin receptors throughout the brain of several fish species, particularly in retinorecipient structures, also indicates a role in visual processing. Despite the absence of solar light many deep-sea organisms show seasonality. The presence of central melatonin receptors was investigated by quantitative in vitro autoradiography in the deep-sea fish Coryphaenoides (Nematonurs) armatus. Specific, time-dependent, saturable, high affinity and guanine nucleotide sensitive, 2-[125]iodomelatonin binding was found over the mid-brain tegmentum and hindbrain. Competing ligand potency was iodomelatonin > melatonin >> 5-HT. Although C.(N.) armatus has well developed eyes no 2-[125]iodomelatonin binding occurred on optic tectum, cerebellum or hypothalamus. Thus melatonin involvement in processing of visual information and control of seasonal physiology via hypothalamic areas appears to be absent in this species. The presence of central G-protein coupled receptors indicates a function for melatonin unrelated to solar light.

Original languageEnglish
Pages (from-to)655-658
Number of pages4
JournalJournal of Neuroendocrinology
Volume8
Issue number9
DOIs
Publication statusPublished - 17 Sep 1996

Keywords

  • melatonin
  • receptors
  • brain
  • Coryphaeniodes
  • deep-sea
  • Atlantic salmon
  • binding-sites
  • pituitary
  • goldfish
  • localization
  • innervation
  • origin

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

Melatonin receptors are present in non-optic regions of the brain of a deep-sea fish living in the absence of solar light. / Smith, A.; Trudeau, V. L.; Williams, L. M.; Martinoli, M. G.; Priede, I. G.

In: Journal of Neuroendocrinology, Vol. 8, No. 9, 17.09.1996, p. 655-658.

Research output: Contribution to journalArticle

Smith, A. ; Trudeau, V. L. ; Williams, L. M. ; Martinoli, M. G. ; Priede, I. G. / Melatonin receptors are present in non-optic regions of the brain of a deep-sea fish living in the absence of solar light. In: Journal of Neuroendocrinology. 1996 ; Vol. 8, No. 9. pp. 655-658.
@article{3cf2d9f7f6dd4320838f2bfbda32e1af,
title = "Melatonin receptors are present in non-optic regions of the brain of a deep-sea fish living in the absence of solar light",
abstract = "Pineal melatonin hormonally transduces photoperiod to influence daily and seasonal cycles in most vertebrates. Evidence of melatonin receptors throughout the brain of several fish species, particularly in retinorecipient structures, also indicates a role in visual processing. Despite the absence of solar light many deep-sea organisms show seasonality. The presence of central melatonin receptors was investigated by quantitative in vitro autoradiography in the deep-sea fish Coryphaenoides (Nematonurs) armatus. Specific, time-dependent, saturable, high affinity and guanine nucleotide sensitive, 2-[125]iodomelatonin binding was found over the mid-brain tegmentum and hindbrain. Competing ligand potency was iodomelatonin > melatonin >> 5-HT. Although C.(N.) armatus has well developed eyes no 2-[125]iodomelatonin binding occurred on optic tectum, cerebellum or hypothalamus. Thus melatonin involvement in processing of visual information and control of seasonal physiology via hypothalamic areas appears to be absent in this species. The presence of central G-protein coupled receptors indicates a function for melatonin unrelated to solar light.",
keywords = "melatonin, receptors, brain, Coryphaeniodes, deep-sea, Atlantic salmon, binding-sites, pituitary, goldfish, localization, innervation, origin",
author = "A. Smith and Trudeau, {V. L.} and Williams, {L. M.} and Martinoli, {M. G.} and Priede, {I. G.}",
year = "1996",
month = "9",
day = "17",
doi = "10.1111/j.1365-2826.1996.tb00702.x",
language = "English",
volume = "8",
pages = "655--658",
journal = "Journal of Neuroendocrinology",
issn = "0953-8194",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - Melatonin receptors are present in non-optic regions of the brain of a deep-sea fish living in the absence of solar light

AU - Smith, A.

AU - Trudeau, V. L.

AU - Williams, L. M.

AU - Martinoli, M. G.

AU - Priede, I. G.

PY - 1996/9/17

Y1 - 1996/9/17

N2 - Pineal melatonin hormonally transduces photoperiod to influence daily and seasonal cycles in most vertebrates. Evidence of melatonin receptors throughout the brain of several fish species, particularly in retinorecipient structures, also indicates a role in visual processing. Despite the absence of solar light many deep-sea organisms show seasonality. The presence of central melatonin receptors was investigated by quantitative in vitro autoradiography in the deep-sea fish Coryphaenoides (Nematonurs) armatus. Specific, time-dependent, saturable, high affinity and guanine nucleotide sensitive, 2-[125]iodomelatonin binding was found over the mid-brain tegmentum and hindbrain. Competing ligand potency was iodomelatonin > melatonin >> 5-HT. Although C.(N.) armatus has well developed eyes no 2-[125]iodomelatonin binding occurred on optic tectum, cerebellum or hypothalamus. Thus melatonin involvement in processing of visual information and control of seasonal physiology via hypothalamic areas appears to be absent in this species. The presence of central G-protein coupled receptors indicates a function for melatonin unrelated to solar light.

AB - Pineal melatonin hormonally transduces photoperiod to influence daily and seasonal cycles in most vertebrates. Evidence of melatonin receptors throughout the brain of several fish species, particularly in retinorecipient structures, also indicates a role in visual processing. Despite the absence of solar light many deep-sea organisms show seasonality. The presence of central melatonin receptors was investigated by quantitative in vitro autoradiography in the deep-sea fish Coryphaenoides (Nematonurs) armatus. Specific, time-dependent, saturable, high affinity and guanine nucleotide sensitive, 2-[125]iodomelatonin binding was found over the mid-brain tegmentum and hindbrain. Competing ligand potency was iodomelatonin > melatonin >> 5-HT. Although C.(N.) armatus has well developed eyes no 2-[125]iodomelatonin binding occurred on optic tectum, cerebellum or hypothalamus. Thus melatonin involvement in processing of visual information and control of seasonal physiology via hypothalamic areas appears to be absent in this species. The presence of central G-protein coupled receptors indicates a function for melatonin unrelated to solar light.

KW - melatonin

KW - receptors

KW - brain

KW - Coryphaeniodes

KW - deep-sea

KW - Atlantic salmon

KW - binding-sites

KW - pituitary

KW - goldfish

KW - localization

KW - innervation

KW - origin

UR - http://www.scopus.com/inward/record.url?scp=0029837798&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2826.1996.tb00702.x

DO - 10.1111/j.1365-2826.1996.tb00702.x

M3 - Article

VL - 8

SP - 655

EP - 658

JO - Journal of Neuroendocrinology

JF - Journal of Neuroendocrinology

SN - 0953-8194

IS - 9

ER -