Memory Impairment is Associated with Serum Methylarginines in Older Adults

Mark McEvoy, Peter Schofield, Wayne Smith, Kingsley Agho, Arduino A. Mangoni, Roy L. Soiza, Roseanne Peel, John Attia

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

BACKGROUND: This study measured serum concentrations of vascular risk factors, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in a representative sample of older community-dwelling adults and determined their associations with objective and subjective memory impairment.

METHODS: Data on clinical, lifestyle, and demographic characteristics, serum ADMA, SDMA, and L-arginine (measured using LC-MS/MS) were collected from a population-based sample of older Australian adults from the Hunter Community Study. Objective memory was measured with the Audio Recorded Cognitive Screen (ARCS) neuropsychological battery and subjective memory impairment was measured using the Memory Complaint Questionnaire (MAC-Q).

RESULTS: Multivariate analysis revealed that SDMA and diabetes were significantly associated with objective memory impairment (Adjusted Odd ratio (AOR) = 3.90; 95% CI. 1.21 - 12.52 for fourth quartile (Q4) of SDMA. ADMA, SDMA, education, number of general practitioner visits and atrial fibrillation were all significantly associated with subjective memory impairment. (AOR = 1.82; 95% CI. 1.04 - 3.18 for Q4 ADMA.

CONCLUSIONS: Higher serum SDMA was associated with objective and subjective memory impairment while higher serum ADMA was associated with subjective memory impairment.

Original languageEnglish
Pages (from-to)97-106
Number of pages10
JournalCurrent Alzheimer Research
Volume11
Issue number1
DOIs
Publication statusPublished - Jan 2014

Bibliographical note

ACKNOWLEDGEMENTS
The research on which this paper is based was conducted as part of the Hunter Community Study, The University of Newcastle. We are grateful to The University of Newcastle for funding and to the men and women of the Hunter region who provided the information recorded.

Keywords

  • ADMA
  • Alzheimer’s disease
  • memory impairment
  • methylarginines
  • nitric oxide
  • older adults
  • SDMA

Fingerprint

Dive into the research topics of 'Memory Impairment is Associated with Serum Methylarginines in Older Adults'. Together they form a unique fingerprint.

Cite this