Memory Impairment is Associated with Serum Methylarginines in Older Adults

Mark McEvoy; Peter Schofield; Wayne Smith; Kingsley Agho; Arduino A. Mangoni; Roy L. Soiza; Roseanne Peel; John Attia

doi:10.2174/15672050113106660178

Memory Impairment is Associated with Serum Methylarginines in Older Adults

Mark McEvoy, Peter Schofield, Wayne Smith, Kingsley Agho, Arduino A. Mangoni, Roy L. Soiza, Roseanne Peel, John Attia

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

BACKGROUND: This study measured serum concentrations of vascular risk factors, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in a representative sample of older community-dwelling adults and determined their associations with objective and subjective memory impairment.

METHODS: Data on clinical, lifestyle, and demographic characteristics, serum ADMA, SDMA, and L-arginine (measured using LC-MS/MS) were collected from a population-based sample of older Australian adults from the Hunter Community Study. Objective memory was measured with the Audio Recorded Cognitive Screen (ARCS) neuropsychological battery and subjective memory impairment was measured using the Memory Complaint Questionnaire (MAC-Q).

RESULTS: Multivariate analysis revealed that SDMA and diabetes were significantly associated with objective memory impairment (Adjusted Odd ratio (AOR) = 3.90; 95% CI. 1.21 - 12.52 for fourth quartile (Q4) of SDMA. ADMA, SDMA, education, number of general practitioner visits and atrial fibrillation were all significantly associated with subjective memory impairment. (AOR = 1.82; 95% CI. 1.04 - 3.18 for Q4 ADMA.

CONCLUSIONS: Higher serum SDMA was associated with objective and subjective memory impairment while higher serum ADMA was associated with subjective memory impairment.

Original language	English
Pages (from-to)	97-106
Number of pages	10
Journal	Current Alzheimer Research
Volume	11
Issue number	1
DOIs	https://doi.org/10.2174/15672050113106660178
Publication status	Published - Jan 2014

Keywords

ADMA
Alzheimer’s disease
memory impairment
methylarginines
nitric oxide
older adults
SDMA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Memory Impairment is Associated with Serum Methylarginines in Older Adults",

abstract = "BACKGROUND: This study measured serum concentrations of vascular risk factors, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in a representative sample of older community-dwelling adults and determined their associations with objective and subjective memory impairment.METHODS: Data on clinical, lifestyle, and demographic characteristics, serum ADMA, SDMA, and L-arginine (measured using LC-MS/MS) were collected from a population-based sample of older Australian adults from the Hunter Community Study. Objective memory was measured with the Audio Recorded Cognitive Screen (ARCS) neuropsychological battery and subjective memory impairment was measured using the Memory Complaint Questionnaire (MAC-Q).RESULTS: Multivariate analysis revealed that SDMA and diabetes were significantly associated with objective memory impairment (Adjusted Odd ratio (AOR) = 3.90; 95% CI. 1.21 - 12.52 for fourth quartile (Q4) of SDMA. ADMA, SDMA, education, number of general practitioner visits and atrial fibrillation were all significantly associated with subjective memory impairment. (AOR = 1.82; 95% CI. 1.04 - 3.18 for Q4 ADMA.CONCLUSIONS: Higher serum SDMA was associated with objective and subjective memory impairment while higher serum ADMA was associated with subjective memory impairment.",

keywords = "ADMA, Alzheimer{\textquoteright}s disease, memory impairment, methylarginines, nitric oxide, older adults, SDMA",

author = "Mark McEvoy and Peter Schofield and Wayne Smith and Kingsley Agho and Mangoni, {Arduino A.} and Soiza, {Roy L.} and Roseanne Peel and John Attia",

note = "ACKNOWLEDGEMENTS The research on which this paper is based was conducted as part of the Hunter Community Study, The University of Newcastle. We are grateful to The University of Newcastle for funding and to the men and women of the Hunter region who provided the information recorded.",

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doi = "10.2174/15672050113106660178",

language = "English",

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T1 - Memory Impairment is Associated with Serum Methylarginines in Older Adults

AU - McEvoy, Mark

AU - Schofield, Peter

AU - Smith, Wayne

AU - Agho, Kingsley

AU - Mangoni, Arduino A.

AU - Soiza, Roy L.

AU - Peel, Roseanne

AU - Attia, John

N1 - ACKNOWLEDGEMENTS The research on which this paper is based was conducted as part of the Hunter Community Study, The University of Newcastle. We are grateful to The University of Newcastle for funding and to the men and women of the Hunter region who provided the information recorded.

PY - 2014/1

Y1 - 2014/1

N2 - BACKGROUND: This study measured serum concentrations of vascular risk factors, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in a representative sample of older community-dwelling adults and determined their associations with objective and subjective memory impairment.METHODS: Data on clinical, lifestyle, and demographic characteristics, serum ADMA, SDMA, and L-arginine (measured using LC-MS/MS) were collected from a population-based sample of older Australian adults from the Hunter Community Study. Objective memory was measured with the Audio Recorded Cognitive Screen (ARCS) neuropsychological battery and subjective memory impairment was measured using the Memory Complaint Questionnaire (MAC-Q).RESULTS: Multivariate analysis revealed that SDMA and diabetes were significantly associated with objective memory impairment (Adjusted Odd ratio (AOR) = 3.90; 95% CI. 1.21 - 12.52 for fourth quartile (Q4) of SDMA. ADMA, SDMA, education, number of general practitioner visits and atrial fibrillation were all significantly associated with subjective memory impairment. (AOR = 1.82; 95% CI. 1.04 - 3.18 for Q4 ADMA.CONCLUSIONS: Higher serum SDMA was associated with objective and subjective memory impairment while higher serum ADMA was associated with subjective memory impairment.

AB - BACKGROUND: This study measured serum concentrations of vascular risk factors, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in a representative sample of older community-dwelling adults and determined their associations with objective and subjective memory impairment.METHODS: Data on clinical, lifestyle, and demographic characteristics, serum ADMA, SDMA, and L-arginine (measured using LC-MS/MS) were collected from a population-based sample of older Australian adults from the Hunter Community Study. Objective memory was measured with the Audio Recorded Cognitive Screen (ARCS) neuropsychological battery and subjective memory impairment was measured using the Memory Complaint Questionnaire (MAC-Q).RESULTS: Multivariate analysis revealed that SDMA and diabetes were significantly associated with objective memory impairment (Adjusted Odd ratio (AOR) = 3.90; 95% CI. 1.21 - 12.52 for fourth quartile (Q4) of SDMA. ADMA, SDMA, education, number of general practitioner visits and atrial fibrillation were all significantly associated with subjective memory impairment. (AOR = 1.82; 95% CI. 1.04 - 3.18 for Q4 ADMA.CONCLUSIONS: Higher serum SDMA was associated with objective and subjective memory impairment while higher serum ADMA was associated with subjective memory impairment.

KW - ADMA

KW - Alzheimer’s disease

KW - memory impairment

KW - methylarginines

KW - nitric oxide

KW - older adults

KW - SDMA

U2 - 10.2174/15672050113106660178

DO - 10.2174/15672050113106660178

M3 - Article

C2 - 24156258

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SP - 97

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JO - Current Alzheimer Research

JF - Current Alzheimer Research

SN - 1567-2050

IS - 1

ER -

Memory Impairment is Associated with Serum Methylarginines in Older Adults

Abstract

Keywords

UN SDGs

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