Abstract
BACKGROUND: This study measured serum concentrations of vascular risk factors, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in a representative sample of older community-dwelling adults and determined their associations with objective and subjective memory impairment.
METHODS: Data on clinical, lifestyle, and demographic characteristics, serum ADMA, SDMA, and L-arginine (measured using LC-MS/MS) were collected from a population-based sample of older Australian adults from the Hunter Community Study. Objective memory was measured with the Audio Recorded Cognitive Screen (ARCS) neuropsychological battery and subjective memory impairment was measured using the Memory Complaint Questionnaire (MAC-Q).
RESULTS: Multivariate analysis revealed that SDMA and diabetes were significantly associated with objective memory impairment (Adjusted Odd ratio (AOR) = 3.90; 95% CI. 1.21 - 12.52 for fourth quartile (Q4) of SDMA. ADMA, SDMA, education, number of general practitioner visits and atrial fibrillation were all significantly associated with subjective memory impairment. (AOR = 1.82; 95% CI. 1.04 - 3.18 for Q4 ADMA.
CONCLUSIONS: Higher serum SDMA was associated with objective and subjective memory impairment while higher serum ADMA was associated with subjective memory impairment.
Original language | English |
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Pages (from-to) | 97-106 |
Number of pages | 10 |
Journal | Current Alzheimer Research |
Volume | 11 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2014 |
Bibliographical note
ACKNOWLEDGEMENTSThe research on which this paper is based was conducted as part of the Hunter Community Study, The University of Newcastle. We are grateful to The University of Newcastle for funding and to the men and women of the Hunter region who provided the information recorded.
Keywords
- ADMA
- Alzheimer’s disease
- memory impairment
- methylarginines
- nitric oxide
- older adults
- SDMA