Memory in Fungal Pathogens Promotes Immune Evasion, Colonisation, and Infection

Alistair J. P. Brown; Neil A. R. Gow; Adilia Warris; Gordon D. Brown

doi:10.1016/j.tim.2018.11.001

Memory in Fungal Pathogens Promotes Immune Evasion, Colonisation, and Infection

Alistair J. P. Brown^* (Corresponding Author), Neil A. R. Gow, Adilia Warris, Gordon D. Brown

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

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Abstract

By analogy with Pavlov’s dogs, certain pathogens have evolved anticipatory behaviours that exploit specific signals in the human host to prepare themselves against imminent host challenges. This adaptive prediction, a type of history-dependent microbial behaviour, represents a primitive form of microbial memory. For fungal pathogens, adaptive prediction helps them circumvent nutritional immunity, protects them against phagocytic killing, and activates immune evasion strategies. We describe how these anticipatory responses, and the contrasting lifestyles and evolutionary trajectories of fungal pathogens, have influenced the evolution of such adaptive behaviours, and how these behaviours affect host colonisation and infection.

Original language	English
Pages (from-to)	219-230
Number of pages	11
Journal	Trends in Microbiology
Volume	27
Issue number	3
Early online date	30 Nov 2018
DOIs	https://doi.org/10.1016/j.tim.2018.11.001
Publication status	Published - Mar 2019

Bibliographical note

We are grateful to our colleagues in the medical mycology and fungal immunology communities for many stimulating and enjoyable discussions. We also thank Wai-Lum Sung for his help with the figures. The authors are directors of the Medical Research Council Centre for Medical Mycology at the University of Aberdeen led by GDB (MR/N006364/1). They are also funded by a Strategic Award from the Wellcome Trust [www.wellcome.ac.uk] led by NARG (097377). AJPB and NARG are funded by a programme grant from the UK Medical Research Council [www.mrc.ac.uk] (MR/M026663/1). NARG and GDB are supported by Wellcome Trust Investigator Awards (099215, 102705). NARG has additional awards from the Wellcome Trust (075470, 080088, 086827). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Keywords

fungal pathogenicity
immune evasion
fungal infection
fungal adaptation
adaptive prediction
fungal memory
COMPLEMENT EVASION
ASPERGILLUS-FUMIGATUS
STRESS-RESPONSE
VIRULENCE
ADAPTIVE PREDICTION
ENVIRONMENTAL-CHANGES
BETA-GLUCAN RECEPTOR
CANDIDA-ALBICANS
HYPHAL GROWTH
TRANSCRIPTIONAL RESPONSE

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 627 KBLicence: CC BY-NC-ND

Cite this

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title = "Memory in Fungal Pathogens Promotes Immune Evasion, Colonisation, and Infection",

abstract = "By analogy with Pavlov{\textquoteright}s dogs, certain pathogens have evolved anticipatory behaviours that exploit specific signals in the human host to prepare themselves against imminent host challenges. This adaptive prediction, a type of history-dependent microbial behaviour, represents a primitive form of microbial memory. For fungal pathogens, adaptive prediction helps them circumvent nutritional immunity, protects them against phagocytic killing, and activates immune evasion strategies. We describe how these anticipatory responses, and the contrasting lifestyles and evolutionary trajectories of fungal pathogens, have influenced the evolution of such adaptive behaviours, and how these behaviours affect host colonisation and infection.",

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note = "We are grateful to our colleagues in the medical mycology and fungal immunology communities for many stimulating and enjoyable discussions. We also thank Wai-Lum Sung for his help with the figures. The authors are directors of the Medical Research Council Centre for Medical Mycology at the University of Aberdeen led by GDB (MR/N006364/1). They are also funded by a Strategic Award from the Wellcome Trust [www.wellcome.ac.uk] led by NARG (097377). AJPB and NARG are funded by a programme grant from the UK Medical Research Council [www.mrc.ac.uk] (MR/M026663/1). NARG and GDB are supported by Wellcome Trust Investigator Awards (099215, 102705). NARG has additional awards from the Wellcome Trust (075470, 080088, 086827). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.",

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N2 - By analogy with Pavlov’s dogs, certain pathogens have evolved anticipatory behaviours that exploit specific signals in the human host to prepare themselves against imminent host challenges. This adaptive prediction, a type of history-dependent microbial behaviour, represents a primitive form of microbial memory. For fungal pathogens, adaptive prediction helps them circumvent nutritional immunity, protects them against phagocytic killing, and activates immune evasion strategies. We describe how these anticipatory responses, and the contrasting lifestyles and evolutionary trajectories of fungal pathogens, have influenced the evolution of such adaptive behaviours, and how these behaviours affect host colonisation and infection.

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Memory in Fungal Pathogens Promotes Immune Evasion, Colonisation, and Infection

Abstract

Bibliographical note

Keywords

UN SDGs

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