Memory in Fungal Pathogens Promotes Immune Evasion, Colonisation, and Infection

Alistair J. P. Brown (Corresponding Author), Neil A. R. Gow, Adilia Warris, Gordon D. Brown

Research output: Contribution to journalArticle

9 Citations (Scopus)
1 Downloads (Pure)

Abstract

By analogy with Pavlov’s dogs, certain pathogens have evolved anticipatory behaviours that exploit specific signals in the human host to prepare themselves against imminent host challenges. This adaptive prediction, a type of history-dependent microbial behaviour, represents a primitive form of microbial memory. For fungal pathogens, adaptive prediction helps them circumvent nutritional immunity, protects them against phagocytic killing, and activates immune evasion strategies. We describe how these anticipatory responses, and the contrasting lifestyles and evolutionary trajectories of fungal pathogens, have influenced the evolution of such adaptive behaviours, and how these behaviours affect host colonisation and infection.
Original languageEnglish
Pages (from-to)219-230
Number of pages11
JournalTrends in Microbiology
Volume27
Issue number3
Early online date30 Nov 2018
DOIs
Publication statusPublished - Mar 2019

    Fingerprint

Keywords

  • fungal pathogenicity
  • immune evasion
  • fungal infection
  • fungal adaptation
  • adaptive prediction
  • fungal memory
  • COMPLEMENT EVASION
  • ASPERGILLUS-FUMIGATUS
  • STRESS-RESPONSE
  • VIRULENCE
  • ADAPTIVE PREDICTION
  • ENVIRONMENTAL-CHANGES
  • BETA-GLUCAN RECEPTOR
  • CANDIDA-ALBICANS
  • HYPHAL GROWTH
  • TRANSCRIPTIONAL RESPONSE

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Virology
  • Microbiology

Cite this