Meta-Analysis of Adipose Tissue Derived Cell-Based Therapy for the Treatment of Knee Osteoarthritis

Nikhil Agarwal, Christopher Mak, Christine Bojanic, Kendrick To, Wasim Khan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Osteoarthritis (OA) is a degenerative disorder associated with cartilage loss and is a leading cause of disability around the world. In old age, the capacity of cartilage to regenerate is diminished. With an aging population, the burden of OA is set to rise. Currently, there is no definitive treatment for OA. However, cell-based therapies derived from adipose tissue are promising. A PRISMA systematic review was conducted employing four databases (MEDLINE, EMBASE, Cochrane, Web of Science) to identify all clinical studies that utilized adipose tissue derived mesenchymal stem cells (AMSCs) or stromal vascular fraction (SVF) for the treatment of knee OA. Eighteen studies were included, which met the inclusion criteria. Meta-analyses were conducted on fourteen of these studies, which all documented WOMAC scores after the administration of AMSCs. Pooled analysis revealed that cell-based treatments definitively improve WOMAC scores, post treatment. These improvements increased with time. The studies in this meta-analysis have established the safety and efficacy of both AMSC therapy and SVF therapy for knee OA in old adults and show that they reduce pain and improve knee function in symptomatic knee OA suggesting that they may be effective therapies to improve mobility in an aging population.
Original languageEnglish
Article numbere1365
Number of pages31
JournalCells
Volume10
Issue number6
Early online date1 Jun 2021
DOIs
Publication statusE-pub ahead of print - 1 Jun 2021

Keywords

  • osteoarthritis
  • degenerative changes
  • knee
  • adipose tissue
  • mesenchymal stem cells
  • stromal vascular factor

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