Metabolic and structural skeletal muscle health in systemic lupus erythematosus related fatigue: a multi-modal magnetic resonance imaging study

Sai Man Cheung, Karen Keenan, Nicholas Senn, Gayle Hutcheon, Kwoshing Chan, Lars Erwig, Andrew Schrepf, Paula Dospinescu, Stuart Gray, Gordon Waiter, Jiabo He, Neil Basu (Corresponding Author)

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: This study aimed to investigate the potential structural and metabolic role of skeletal muscle in SLE related fatigue. Methods: A case control, multi-modal MRI study was conducted. Cases were inactive SLE patients who reported chronic fatigue. Controls were age/sex matched healthy members of the general population. Participants were clinically characterised and then underwent a 3T whole body MRI scan. Resting and dynamic 31 Phosphorous Magnetic Resonance Spectroscopy (MRS) of the calf muscles was applied from which phosphocreatine recovery half time (PCr), a marker of mitochondrial dysfunction, was computed. In addition, microstructural sequences (T1-weighted anatomical images, T2 mapping and diffusion tensor imaging) were acquired. Descriptive statistics evaluated group differences and within case physical fatigue correlations were explored. Results: Of the 37 recruits (mean age= 43.8 years, 89.2% female), cases (n=19) reported higher levels of physical fatigue, pain, depression and sleep disturbance compared to the control group (p<0.0001). PCr was greater (p=0.045) among cases (33.0+/-9.0s) compared to controls (27.1+/-6.6s). No micro-structural group differences were observed. Within cases, physical fatigue did not correlate with PCr (r=-0.28, p=0.25). Conclusion: We report preliminary data evidencing greater skeletal muscle mitochondrial dysfunction among fatigued SLE patients compared to healthy controls.
Original languageEnglish
Pages (from-to)1640-1646
Number of pages7
JournalArthritis Care & Research
Volume71
Issue number12
Early online date29 Nov 2019
DOIs
Publication statusPublished - Dec 2019

Keywords

  • systemic lupus erythematosus
  • fatigue
  • skeletal muscle
  • CRITERIA
  • ABNORMALITIES
  • STEP TEST
  • EXERCISE
  • FAT QUANTIFICATION
  • INITIAL VALIDATION
  • PERIPHERAL MUSCLE
  • DISEASES
  • SPECTROSCOPY
  • SEPARATION

ASJC Scopus subject areas

  • Rheumatology

Fingerprint Dive into the research topics of 'Metabolic and structural skeletal muscle health in systemic lupus erythematosus related fatigue: a multi-modal magnetic resonance imaging study'. Together they form a unique fingerprint.

  • Cite this