Metabolic changes in hypertrophic cardiomyopathies: Scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

Jolanda van der Velden; Carlo Gabriele Tocchetti; Gilda Varricchi; Anna Bianco; Vasco Sequeira; Denise Hilfiker-Kleiner; Nazha Hamdani; Adelino Leite-Moreira; Manuel Mayr; Ines Falcão-Pires; Thomas Thum; Dana K Dawson; Jean-Luc Balligand; Stephane Heymans

doi:10.1093/cvr/cvy147

Metabolic changes in hypertrophic cardiomyopathies: Scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

Jolanda van der Velden, Carlo Gabriele Tocchetti, Gilda Varricchi, Anna Bianco, Vasco Sequeira, Denise Hilfiker-Kleiner, Nazha Hamdani, Adelino Leite-Moreira, Manuel Mayr, Ines Falcão-Pires, Thomas Thum, Dana K Dawson, Jean-Luc Balligand, Stephane Heymans

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Abstract

Disturbed metabolism as a consequence of obesity and diabetes may cause cardiac diseases (recently highlighted in the CVR spotlight issue on Metabolic cardiomyopathies).1 In turn, the metabolism of the heart may also be disturbed in genetic and acquired forms of hypertrophic cardiac disease. Here, we provide an overview of recent insights on metabolic changes in genetic hypertrophic cardiomyopathy (HCM) and discuss several therapies which may be explored to target disturbed metabolism and prevent onset of cardiac hypertrophy.

Original language	English
Pages (from-to)	1273-1280
Number of pages	8
Journal	Cardiovascular Research
Volume	114
Issue number	10
Early online date	15 Jun 2018
DOIs	https://doi.org/10.1093/cvr/cvy147
Publication status	Published - 1 Aug 2018

Keywords

Journal Article
hypertrophic cardiomyopathy
mutations
metabolism

UN SDGs

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10.1093/cvr/cvy147Licence: CC BY-NC

Metabolic changes in hypertrophic cardiomyopathies
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van der Velden, J., Gabriele Tocchetti, C., Varricchi, G., Bianco, A., Sequeira, V., Hilfiker-Kleiner, D., Hamdani, N., Leite-Moreira, A., Mayr, M., Falcão-Pires, I., Thum, T., Dawson, D. K., Balligand, J-L., & Heymans, S. (2018). Metabolic changes in hypertrophic cardiomyopathies: Scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. Cardiovascular Research, 114(10), 1273-1280. https://doi.org/10.1093/cvr/cvy147

Metabolic changes in hypertrophic cardiomyopathies : Scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. / van der Velden, Jolanda; Gabriele Tocchetti, Carlo; Varricchi, Gilda et al.

In: Cardiovascular Research, Vol. 114, No. 10, 01.08.2018, p. 1273-1280.

Research output: Contribution to journal › Article › peer-review

van der Velden, J, Gabriele Tocchetti, C, Varricchi, G, Bianco, A, Sequeira, V, Hilfiker-Kleiner, D, Hamdani, N, Leite-Moreira, A, Mayr, M, Falcão-Pires, I, Thum, T, Dawson, DK, Balligand, J-L & Heymans, S 2018, 'Metabolic changes in hypertrophic cardiomyopathies: Scientific update from the Working Group of Myocardial Function of the European Society of Cardiology', Cardiovascular Research, vol. 114, no. 10, pp. 1273-1280. https://doi.org/10.1093/cvr/cvy147

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abstract = "Disturbed metabolism as a consequence of obesity and diabetes may cause cardiac diseases (recently highlighted in the CVR spotlight issue on Metabolic cardiomyopathies).1 In turn, the metabolism of the heart may also be disturbed in genetic and acquired forms of hypertrophic cardiac disease. Here, we provide an overview of recent insights on metabolic changes in genetic hypertrophic cardiomyopathy (HCM) and discuss several therapies which may be explored to target disturbed metabolism and prevent onset of cardiac hypertrophy.",

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AU - Bianco, Anna

AU - Sequeira, Vasco

AU - Hilfiker-Kleiner, Denise

AU - Hamdani, Nazha

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Metabolic changes in hypertrophic cardiomyopathies: Scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

Abstract

Keywords

UN SDGs

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