Metabolic changes in hypertrophic cardiomyopathies: Scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

Jolanda van der Velden, Carlo Gabriele Tocchetti, Gilda Varricchi, Anna Bianco, Vasco Sequeira, Denise Hilfiker-Kleiner, Nazha Hamdani, Adelino Leite-Moreira, Manuel Mayr, Ines Falcão-Pires, Thomas Thum, Dana K Dawson, Jean-Luc Balligand, Stephane Heymans

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Abstract

Disturbed metabolism as a consequence of obesity and diabetes may cause cardiac diseases (recently highlighted in the CVR spotlight issue on Metabolic cardiomyopathies).1 In turn, the metabolism of the heart may also be disturbed in genetic and acquired forms of hypertrophic cardiac disease. Here, we provide an overview of recent insights on metabolic changes in genetic hypertrophic cardiomyopathy (HCM) and discuss several therapies which may be explored to target disturbed metabolism and prevent onset of cardiac hypertrophy.

Original languageEnglish
Pages (from-to)1273-1280
Number of pages8
JournalCardiovascular Research
Volume114
Issue number10
Early online date15 Jun 2018
DOIs
Publication statusPublished - 1 Aug 2018

Keywords

  • Journal Article
  • hypertrophic cardiomyopathy
  • mutations
  • metabolism

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    van der Velden, J., Gabriele Tocchetti, C., Varricchi, G., Bianco, A., Sequeira, V., Hilfiker-Kleiner, D., Hamdani, N., Leite-Moreira, A., Mayr, M., Falcão-Pires, I., Thum, T., Dawson, D. K., Balligand, J-L., & Heymans, S. (2018). Metabolic changes in hypertrophic cardiomyopathies: Scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. Cardiovascular Research, 114(10), 1273-1280. https://doi.org/10.1093/cvr/cvy147