Metabolic maturation in the first 2 years of life in resource-constrained settings and its association with postnatal growths

N. Giallourou, F. Fardus-Reid, G. Panic, K. Veselkov, B. J.J. McCormick, M. P. Olortegui, T. Ahmed, E. Mduma, P. P. Yori, M. Mahfuz, E. Svensen, M. M.M. Ahmed, J. M. Colston, M. N. Kosek*, J. R. Swann

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Malnutrition continues to affect the growth and development of millions of children worldwide, and chronic undernutrition has proven to be largely refractory to interventions. Improved understanding of metabolic development in infancy and how it differs in growth-constrained children may provide insights to inform more timely, targeted, and effective interventions. Here, the metabolome of healthy infants was compared to that of growth-constrained infants from three continents over the first 2 years of life to identify metabolic signatures of aging. Predictive models demonstrated that growth-constrained children lag in their metabolic maturity relative to their healthier peers and that metabolic maturity can predict growth 6 months into the future. Our results provide a metabolic framework from which future nutritional programs may be more precisely constructed and evaluated.

Original languageEnglish
Article numbereaay5969
Number of pages11
JournalScience Advances
Volume6
Issue number15
Early online date8 Apr 2020
DOIs
Publication statusPublished - 8 Apr 2020

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