Metabolic profiling of lignan varibality in Linum species of section syllinum native to Bulgaria

Nikolay Vasilev, Rainer Ebel, RuAngelie Edrada, Elisabeth Fuss, A. Wilhelm Alfermann, Iliana Ionkova, Ana Petrova, Miriam Repplinger, Thomas J. Schmidt

Research output: Contribution to journalArticle

28 Citations (Scopus)


Lignans in eighteen samples of Linum species (L. tauricum ssp. touricurn, serbicum, bulgaricum and linearifolium; L. elegans; Lflavum ssp. sparsi-florum, L. capitatum var. laxiflorum), all members of the section Syllinum occurring in Bulgaria, were analysed by HPLC-ESI/MS and HPLC-UV/ DAD. The ESI/MS fragmentation pathways recently established for aryltetralin lignans are now extended to ester and glycoside derivatives. In total, 22 different lignans, mainly of the aryltetralin type, were identified. 6-Methoxypodophyllotoxin and its glucoside were present as major constituents in all samples. Differences between the investigated taxa were observed especially with respect to the accumulation of 6-deoxy-7hydroxy-aryltetralins such as poclophyllotoxin and of 6-hydroxy-7-deoxy-aryltetralin lignans of the peltatin type. The distribution of aryltetralin lignans with different oxygenation patterns in the various samples, and correlations between the chemical data and the molecular phylogeny based on an analysis of ITS sequences of the investigated species are discussed.

Original languageEnglish
Pages (from-to)273-280
Number of pages8
JournalPlanta Medica
Issue number3
Publication statusPublished - Feb 2008


  • aryltetralin lignan
  • Linum L.
  • Linaceae
  • chemical and molecular systematics
  • cell-suspension cultures
  • in-vitro cultures
  • accumulation
  • flavum


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