Metabolic Syndrome Patients Have Lower Levels of Adropin When Compared With Healthy Overweight/Obese and Lean Subjects

Somaye Yosaee, Mahmoud Khodadost, Alireza Esteghamati, John R. Speakman, Farzad Shidfar, Mahdiyeh Nasab Nazari, Vida Bitarafan, Kurosh Djafarian*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Metabolic syndrome (MetS), a cluster of cardiometabolic risk factors, is a challenging public health issue. The aim of current study was to test the hypothesis that concentrations of plasma adropin and leptin differ between patients with MetS and comparable age- and sex-matched control groups. This case-control study involved 153 subjects (51 per group). The study group included obese subjects with MetS and the two control groups included weight-matched subjects without MetS (“healthy”: obese) and normal weight subjects without MetS. Body composition parameters were measured using bioelectrical impedance analysis. Plasma levels of adropin, leptin, and their ratio were measured. Leptin was significantly different between obese patients with/without MetS groups and normal weight subjects. Patients with MetS had higher levels of leptin (14 ± 12.4) compared with those without MetS (11.2 ± 9.3 vs. 7 ± 7.1 obese and normal weight without MetS, respectively; p =.002). Compared with healthy obese and normal weight subjects, MetS subjects had lower levels of plasma adropin (p <.001) and a lower plasma adropin to leptin ratio (p <.001), which remained significant when adjusted for body fat mass by analysis of covariance (p <.001). This study demonstrates low levels of adropin are correlated with MetS and hence identify it as a potentially protective agent against MetS development. Variation in adropin levels may partly explain the “healthy obese” phenomenon.

Original languageEnglish
Pages (from-to)426-434
Number of pages9
JournalAmerican Journal of Men's Health
Issue number2
Early online date21 Aug 2016
Publication statusPublished - 1 Mar 2017


  • adropin
  • body composition
  • leptin
  • metabolic syndrome
  • obesity


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