Metabolically labile cannabinoid esters: A 'soft drug' approach for the development of cannabinoid-based therapeutic drugs

F. Minutolo; M. G. Cascio; I. Carboni; T. Bisogno; G. Prota; S. Bertini; M. Digiacomo; M. Bifulco; V. Di Marzo; M. Macchia

doi:10.1016/j.bmcl.2007.06.055

Metabolically labile cannabinoid esters: A 'soft drug' approach for the development of cannabinoid-based therapeutic drugs

F. Minutolo^*, M. G. Cascio, I. Carboni, T. Bisogno, G. Prota, S. Bertini, M. Digiacomo, M. Bifulco, V. Di Marzo, M. Macchia

^*Corresponding author for this work

Medical Sciences

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Biphenylic ester derivatives, designed by using a 'soft-drug' approach, proved to possess good binding properties toward cannabinoid CB₁ and CB₂ receptors and, at the same time, their metabolically labile ester portion would promote a rapid systemic inactivation. This may constitute a possible solution to the psychotropic side effects encountered when cannabinoids are therapeutically employed as local analgesic or antiglaucoma agents.

Original language	English
Pages (from-to)	4878-4881
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	17
Early online date	20 Jun 2007
DOIs	https://doi.org/10.1016/j.bmcl.2007.06.055
Publication status	Published - 1 Sep 2007

Keywords

Cannabinoids
CB
Retrometabolic
Soft-drugs

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10.1016/j.bmcl.2007.06.055

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Minutolo, F., Cascio, M. G., Carboni, I., Bisogno, T., Prota, G., Bertini, S., Digiacomo, M., Bifulco, M., Di Marzo, V., & Macchia, M. (2007). Metabolically labile cannabinoid esters: A 'soft drug' approach for the development of cannabinoid-based therapeutic drugs. Bioorganic and Medicinal Chemistry Letters, 17(17), 4878-4881. https://doi.org/10.1016/j.bmcl.2007.06.055

Minutolo, F, Cascio, MG, Carboni, I, Bisogno, T, Prota, G, Bertini, S, Digiacomo, M, Bifulco, M, Di Marzo, V & Macchia, M 2007, 'Metabolically labile cannabinoid esters: A 'soft drug' approach for the development of cannabinoid-based therapeutic drugs', Bioorganic and Medicinal Chemistry Letters, vol. 17, no. 17, pp. 4878-4881. https://doi.org/10.1016/j.bmcl.2007.06.055

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abstract = "Biphenylic ester derivatives, designed by using a 'soft-drug' approach, proved to possess good binding properties toward cannabinoid CB1 and CB2 receptors and, at the same time, their metabolically labile ester portion would promote a rapid systemic inactivation. This may constitute a possible solution to the psychotropic side effects encountered when cannabinoids are therapeutically employed as local analgesic or antiglaucoma agents.",

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AU - Minutolo, F.

AU - Cascio, M. G.

AU - Carboni, I.

AU - Bisogno, T.

AU - Prota, G.

AU - Bertini, S.

AU - Digiacomo, M.

AU - Bifulco, M.

AU - Di Marzo, V.

AU - Macchia, M.

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AB - Biphenylic ester derivatives, designed by using a 'soft-drug' approach, proved to possess good binding properties toward cannabinoid CB1 and CB2 receptors and, at the same time, their metabolically labile ester portion would promote a rapid systemic inactivation. This may constitute a possible solution to the psychotropic side effects encountered when cannabinoids are therapeutically employed as local analgesic or antiglaucoma agents.

KW - Cannabinoids

KW - CB

KW - Retrometabolic

KW - Soft-drugs

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Metabolically labile cannabinoid esters: A 'soft drug' approach for the development of cannabinoid-based therapeutic drugs

Abstract

Keywords

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