Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels

Alistair J P Brown, Gordon D Brown, Mihai G Netea, Neil A R Gow

Research output: Contribution to journalArticle

100 Citations (Scopus)
4 Downloads (Pure)

Abstract

Metabolism is integral to the pathogenicity of Candida albicans, a major fungal pathogen of humans. As well as providing the platform for nutrient assimilation and growth in diverse host niches, metabolic adaptation affects the susceptibility of C. albicans to host-imposed stresses and antifungal drugs, the expression of key virulence factors, and fungal vulnerability to innate immune defences. These effects, which are driven by complex regulatory networks linking metabolism, morphogenesis, stress adaptation, and cell wall remodelling, influence commensalism and infection. Therefore, current concepts of Candida-host interactions must be extended to include the impact of metabolic adaptation upon pathogenicity and immunogenicity.

Original languageEnglish
Pages (from-to)614-622
Number of pages9
JournalTrends in Microbiology
Volume22
Issue number11
Early online date31 Jul 2014
DOIs
Publication statusPublished - Nov 2014

Keywords

  • metabolic adaptation
  • stress adaptation
  • cell wall
  • virulence factors
  • regulatory networks
  • fungal immunology

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