Metal-specific risk assessment

the European perspective

Violaine Verougstraete, Rodger Battersby, Lorraine Gambling, Harry J McArdle

Research output: Contribution to journalArticle

Abstract

This review considers the development of the regulatory process for metals in the European Union (Regulation for Registration, Evaluation, Authorisation and Restriction of Chemicals, REACH). The manner in which the REACH process was developed, its history, and the relative involvement of government and industry are examined. The problems involved in setting up the system and the steps in optimisation are considered. One of the major difficulties in the development of the REACH mechanism was incorporating the fact that many metals are essential elements, which is not a factor that most toxicological examinations consider. How the REACH process evolved to deal with these problems and how the mechanisms were put in place to overcome them is examined. Looking specifically at examples of industry working with academia, one needs to consider how a risk assessment can be developed and submitted in a timely and successful fashion.

Original languageEnglish
Pages (from-to)101-107
Number of pages7
JournalJournal of Toxicology and Environmental Health. Part A
Volume73
Issue number2-3
DOIs
Publication statusPublished - Jan 2010

Keywords

  • kinky-hair syndrome
  • postmenopausal women
  • dietary zinc
  • copper

Cite this

Metal-specific risk assessment : the European perspective. / Verougstraete, Violaine; Battersby, Rodger; Gambling, Lorraine; McArdle, Harry J.

In: Journal of Toxicology and Environmental Health. Part A, Vol. 73, No. 2-3, 01.2010, p. 101-107.

Research output: Contribution to journalArticle

Verougstraete, Violaine ; Battersby, Rodger ; Gambling, Lorraine ; McArdle, Harry J. / Metal-specific risk assessment : the European perspective. In: Journal of Toxicology and Environmental Health. Part A. 2010 ; Vol. 73, No. 2-3. pp. 101-107.
@article{e725ea64b14940b894b928d34a1e6fab,
title = "Metal-specific risk assessment: the European perspective",
abstract = "This review considers the development of the regulatory process for metals in the European Union (Regulation for Registration, Evaluation, Authorisation and Restriction of Chemicals, REACH). The manner in which the REACH process was developed, its history, and the relative involvement of government and industry are examined. The problems involved in setting up the system and the steps in optimisation are considered. One of the major difficulties in the development of the REACH mechanism was incorporating the fact that many metals are essential elements, which is not a factor that most toxicological examinations consider. How the REACH process evolved to deal with these problems and how the mechanisms were put in place to overcome them is examined. Looking specifically at examples of industry working with academia, one needs to consider how a risk assessment can be developed and submitted in a timely and successful fashion.",
keywords = "kinky-hair syndrome, postmenopausal women, dietary zinc, copper",
author = "Violaine Verougstraete and Rodger Battersby and Lorraine Gambling and McArdle, {Harry J}",
year = "2010",
month = "1",
doi = "10.1080/15287390903337076",
language = "English",
volume = "73",
pages = "101--107",
journal = "Journal of Toxicology and Environmental Health. Part A",
issn = "1528-7394",
publisher = "Taylor and Francis Ltd.",
number = "2-3",

}

TY - JOUR

T1 - Metal-specific risk assessment

T2 - the European perspective

AU - Verougstraete, Violaine

AU - Battersby, Rodger

AU - Gambling, Lorraine

AU - McArdle, Harry J

PY - 2010/1

Y1 - 2010/1

N2 - This review considers the development of the regulatory process for metals in the European Union (Regulation for Registration, Evaluation, Authorisation and Restriction of Chemicals, REACH). The manner in which the REACH process was developed, its history, and the relative involvement of government and industry are examined. The problems involved in setting up the system and the steps in optimisation are considered. One of the major difficulties in the development of the REACH mechanism was incorporating the fact that many metals are essential elements, which is not a factor that most toxicological examinations consider. How the REACH process evolved to deal with these problems and how the mechanisms were put in place to overcome them is examined. Looking specifically at examples of industry working with academia, one needs to consider how a risk assessment can be developed and submitted in a timely and successful fashion.

AB - This review considers the development of the regulatory process for metals in the European Union (Regulation for Registration, Evaluation, Authorisation and Restriction of Chemicals, REACH). The manner in which the REACH process was developed, its history, and the relative involvement of government and industry are examined. The problems involved in setting up the system and the steps in optimisation are considered. One of the major difficulties in the development of the REACH mechanism was incorporating the fact that many metals are essential elements, which is not a factor that most toxicological examinations consider. How the REACH process evolved to deal with these problems and how the mechanisms were put in place to overcome them is examined. Looking specifically at examples of industry working with academia, one needs to consider how a risk assessment can be developed and submitted in a timely and successful fashion.

KW - kinky-hair syndrome

KW - postmenopausal women

KW - dietary zinc

KW - copper

U2 - 10.1080/15287390903337076

DO - 10.1080/15287390903337076

M3 - Article

VL - 73

SP - 101

EP - 107

JO - Journal of Toxicology and Environmental Health. Part A

JF - Journal of Toxicology and Environmental Health. Part A

SN - 1528-7394

IS - 2-3

ER -