Methodologic considerations in randomized clinical trials in reproductive medicine

Christos Venetis, Thomas d'Hooghe, Kurt T. Barnhart, Patrick M.M. Bossuyt, Ben Willem J. Mol*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Randomized controlled trials (RCTs) are the cornerstone of evidence-based medicine. In this series in Fertility and Sterility, several aspects of RCTs are discussed, with contributions on multicenter RCTs, different international settings, and integrity of RCTs. The present contribution deals with methodologic issues. We discuss different types of RCTs based on null hypothesis (superiority vs. noninferiority vs. equivalence) as well as frequentist versus Bayesian interpretation. We also discuss the use of RCTs in the era of personalized medicine and RCTs to address diagnostic and prognostic questions. Finally, we address the use of big data compared with the use of RCTs.

Original languageEnglish
Pages (from-to)1107-1112
Number of pages6
JournalFertility and Sterility
Volume113
Issue number6
Early online date30 May 2020
DOIs
Publication statusPublished - Jun 2020

Keywords

  • bayesian analysis
  • big data
  • frequentist approach
  • methodology
  • personalized medicine
  • Randomized clinical trial
  • DESIGN
  • PROGESTERONE
  • MODEL
  • PREDICTION
  • BAYESIAN METHODS
  • WOMEN
  • BIG DATA
  • TECHNOLOGY

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