Methods for handling missing data in palliative care research

Shona Fielding, Peter Fayers, J. H. Loge, M. S. Jordhoy, S. Kaasa

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Missing data is a common problem in palliative care research due to the special characteristics (deteriorating condition, fatigue and cachexia) of the population. Using data from a palliative study, we illustrate the problems that missing data can cause and show some approaches for dealing with it. Reasons for missing data and ways to deal with missing data (including complete case analysis, imputation and modelling procedures) are explored. Possible mechanisms behind the missing data are: missing completely at random, missing at random or missing not at random. In the example study, data are shown to be missing at random. Imputation of missing data is commonly used (including last value carried forward, regression procedures and simple mean). Imputation affects subsequent summary statistics and analyses, and can have a substantial impact on estimated group means and standard deviations. The choice of imputation method should be carried out with caution and the effects reported.

Original languageEnglish
Pages (from-to)791-798
Number of pages8
JournalPalliative Medicine
Volume20
DOIs
Publication statusPublished - 1 Dec 2006

Keywords

  • EORTC QLQ-C30
  • health-related quality of life
  • imputation
  • missing data
  • QUALITY-OF-LIFE

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