Metoclopramide and propofol to prevent nausea and vomiting during cesarean section under spinal anesthesia: A randomized, placebo-controlled, double-blind trial

Zhirajr Mokini*, Valentina Genocchio, Patrice Forget, Flavia Petrini

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
1 Downloads (Pure)

Abstract

Background: Intra-operative nausea, vomiting and retching (NVR) are frequently associated with subarachnoid anesthesia (SA) in women undergoing cesarean section (CS). In this study performed in women undergoing CS under SA with a risk factor control strategy, we compared saline (placebo), propofol, metoclopramide and both drugs to prevent NVR. Methods: We recorded NVR events in 110 women undergoing CS who were randomized after umbilical cord clamping to receive saline (S; n = 27), metoclopramide 10 mg (M; n = 28), propofol 1 mg/kg/h (P; n = 27) or both drugs (PM; n = 28). Results: The proportion of women with intra-operative nausea was: S: 17/27 (63%); P: 15/27 (56%); M: 13/28 (46%); PM: 6/28 (21%) (p = 0.012, Cramér’s V = 0.31 (large effect). The proportion of women with intra-operative vomiting/retching was: S: 9/27 (33%); M: 7/27 (25%); P: 3/28 (11%); PM 2/28 (7%) (p = 0.049, Cramér’s V = 0.26 (medium effect). Post-hoc multiple comparisons revealed a significant reduction in NVR episodes and NRS scores between the PM group and control. Sedation scores did not differ among groups. Conclusion: In women undergoing CS under SA with a risk factor control strategy, combined propofol and metoclopramide reduce nausea and vomiting.

Original languageEnglish
Article number110
JournalJournal of Clinical Medicine
Volume11
Issue number1
Early online date26 Dec 2021
DOIs
Publication statusPublished - 1 Jan 2022

Bibliographical note

Funding
This research received no external funding.

Acknowledgment

Elisa Fabbri, Ivan Dell’Atti, Fabio Palombo, Massimo di Marzio, Rosalia Di Martino, Daniela Albanese, Nadia D’Urso, Vera Hendrix for their contribution to the present work.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Data Availability Statement

All the data are included in the manuscript.

Keywords

  • Metoclopramide
  • Nausea
  • Propofol
  • Retching
  • Spinal anesthesia
  • Vomiting

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