Abstract
Background: Intra-operative nausea, vomiting and retching (NVR) are frequently associated with subarachnoid anesthesia (SA) in women undergoing cesarean section (CS). In this study performed in women undergoing CS under SA with a risk factor control strategy, we compared saline (placebo), propofol, metoclopramide and both drugs to prevent NVR. Methods: We recorded NVR events in 110 women undergoing CS who were randomized after umbilical cord clamping to receive saline (S; n = 27), metoclopramide 10 mg (M; n = 28), propofol 1 mg/kg/h (P; n = 27) or both drugs (PM; n = 28). Results: The proportion of women with intra-operative nausea was: S: 17/27 (63%); P: 15/27 (56%); M: 13/28 (46%); PM: 6/28 (21%) (p = 0.012, Cramér’s V = 0.31 (large effect). The proportion of women with intra-operative vomiting/retching was: S: 9/27 (33%); M: 7/27 (25%); P: 3/28 (11%); PM 2/28 (7%) (p = 0.049, Cramér’s V = 0.26 (medium effect). Post-hoc multiple comparisons revealed a significant reduction in NVR episodes and NRS scores between the PM group and control. Sedation scores did not differ among groups. Conclusion: In women undergoing CS under SA with a risk factor control strategy, combined propofol and metoclopramide reduce nausea and vomiting.
Original language | English |
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Article number | 110 |
Journal | Journal of Clinical Medicine |
Volume | 11 |
Issue number | 1 |
Early online date | 26 Dec 2021 |
DOIs | |
Publication status | Published - 1 Jan 2022 |
Bibliographical note
FundingThis research received no external funding.
Acknowledgment
Elisa Fabbri, Ivan Dell’Atti, Fabio Palombo, Massimo di Marzio, Rosalia Di Martino, Daniela Albanese, Nadia D’Urso, Vera Hendrix for their contribution to the present work.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Data Availability Statement
All the data are included in the manuscript.Keywords
- Metoclopramide
- Nausea
- Propofol
- Retching
- Spinal anesthesia
- Vomiting