MHC polymorphism and disease resistance in Atlantic salmon (Salmo salar); facing pathogens with single expressed major histocompatibility class I and class II loci

U. Grimholt, S. Larsen, R. Nordmo, P. Midtlyng, S. Kjoeglum, A. Storset, S. Saebo, Rene Josephus Maria Stet

    Research output: Contribution to journalArticle

    233 Citations (Scopus)

    Abstract

    Few studies have yet addressed the functional aspects of MHC molecules in fish. To lay the foundation for this, we evaluated the association between disease resistance and MHC class I and class II polymorphism in Atlantic salmon. Standardized disease challenge trials were performed on a semi-wild Atlantic salmon population with subsequent MHC typing and statistical analysis. The pathogens employed were infectious salmon anaemia virus (ISAV) causing infectious salmon anaemia and the Aeromonas salmonicida bacteria causing furunculosis. The material consisted of 1,182 Atlantic salmon from 33 families challenged with A. salmonicida and 1,031 Atlantic salmon from 25 families challenged with ISAV. We found highly significant associations between resistance towards infectious diseases caused by both pathogens and MH class I and class II polymorphism in Atlantic salmon. The observed associations were detected due to independently segregating MH class I and class II single loci, and inclusion of a large number of fish allowing an extensive statistical analysis.

    Original languageEnglish
    Pages (from-to)210-219
    Number of pages9
    JournalImmunogenetics
    Volume55
    Issue number4
    DOIs
    Publication statusPublished - Jul 2003

    Keywords

    • bacterial infection
    • viral infection
    • major histocompatibility complex
    • quantitative trait locus
    • TROUT ONCORHYNCHUS-MYKISS
    • ORTHOMYXO-LIKE VIRUS
    • COMPLEX CLASS-I
    • RAINBOW-TROUT
    • ANEMIA-VIRUS
    • AFFECTING SUSCEPTIBILITY
    • AEROMONAS-SALMONICIDA
    • NATURAL-SELECTION
    • MAREKS-DISEASE
    • BETA-CHAIN

    Cite this

    MHC polymorphism and disease resistance in Atlantic salmon (Salmo salar); facing pathogens with single expressed major histocompatibility class I and class II loci. / Grimholt, U.; Larsen, S.; Nordmo, R.; Midtlyng, P.; Kjoeglum, S.; Storset, A.; Saebo, S.; Stet, Rene Josephus Maria.

    In: Immunogenetics, Vol. 55, No. 4, 07.2003, p. 210-219.

    Research output: Contribution to journalArticle

    Grimholt, U. ; Larsen, S. ; Nordmo, R. ; Midtlyng, P. ; Kjoeglum, S. ; Storset, A. ; Saebo, S. ; Stet, Rene Josephus Maria. / MHC polymorphism and disease resistance in Atlantic salmon (Salmo salar); facing pathogens with single expressed major histocompatibility class I and class II loci. In: Immunogenetics. 2003 ; Vol. 55, No. 4. pp. 210-219.
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    abstract = "Few studies have yet addressed the functional aspects of MHC molecules in fish. To lay the foundation for this, we evaluated the association between disease resistance and MHC class I and class II polymorphism in Atlantic salmon. Standardized disease challenge trials were performed on a semi-wild Atlantic salmon population with subsequent MHC typing and statistical analysis. The pathogens employed were infectious salmon anaemia virus (ISAV) causing infectious salmon anaemia and the Aeromonas salmonicida bacteria causing furunculosis. The material consisted of 1,182 Atlantic salmon from 33 families challenged with A. salmonicida and 1,031 Atlantic salmon from 25 families challenged with ISAV. We found highly significant associations between resistance towards infectious diseases caused by both pathogens and MH class I and class II polymorphism in Atlantic salmon. The observed associations were detected due to independently segregating MH class I and class II single loci, and inclusion of a large number of fish allowing an extensive statistical analysis.",
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