Microbial degradation of complex carbohydrates in the gut

Research output: Contribution to journalLiterature review

473 Citations (Scopus)

Abstract

Bacteria that colonize the mammalian intestine collectively possess a far larger repertoire of degradative enzymes and metabolic capabilities than their hosts. Microbial fermentation of complex non-digestible dietary carbohydrates and host-derived glycans in the human intestine has important consequences for health. Certain dominant species, notably among the Bacteroidetes, are known to possess very large numbers of genes that encode carbohydrate active enzymes and can switch readily between different energy sources in the gut depending on availability. Nevertheless, more nutritionally specialized bacteria appear to play critical roles in the community by initiating the degradation of complex substrates such as plant cell walls, starch particles and mucin. Examples are emerging from the Firmicutes, Actinobacteria and Verrucomicrobium phyla, but more information is needed on these little studied groups. The impact of dietary carbohydrates, including prebiotics, on human health requires understanding of the complex relationship between diet composition, the gut microbiota and metabolic outputs.
Original languageEnglish
Pages (from-to)289-306
Number of pages18
JournalGut Microbes
Volume3
Issue number4
Early online date10 May 2012
DOIs
Publication statusPublished - 1 Jul 2012

Fingerprint

Dietary Carbohydrates
Intestines
Verrucomicrobia
Carbohydrates
Bacteroidetes
Bacteria
Prebiotics
Actinobacteria
Health
Plant Cells
Mucins
Enzymes
Starch
Cell Wall
Fermentation
Polysaccharides
Diet
Genes
Firmicutes
Gastrointestinal Microbiome

Keywords

  • dietary fiber
  • human intestine
  • microbiota
  • nutrition
  • polysaccharides
  • prebiotics
  • resistant starch

Cite this

Microbial degradation of complex carbohydrates in the gut. / Flint, Harry J.; Scott, Karen P.; Duncan, Sylvia H.; Louis, Petra; Forano, Evelyne.

In: Gut Microbes, Vol. 3, No. 4, 01.07.2012, p. 289-306.

Research output: Contribution to journalLiterature review

@article{3fc13c1cf22c47afb71e7bf33b7aea49,
title = "Microbial degradation of complex carbohydrates in the gut",
abstract = "Bacteria that colonize the mammalian intestine collectively possess a far larger repertoire of degradative enzymes and metabolic capabilities than their hosts. Microbial fermentation of complex non-digestible dietary carbohydrates and host-derived glycans in the human intestine has important consequences for health. Certain dominant species, notably among the Bacteroidetes, are known to possess very large numbers of genes that encode carbohydrate active enzymes and can switch readily between different energy sources in the gut depending on availability. Nevertheless, more nutritionally specialized bacteria appear to play critical roles in the community by initiating the degradation of complex substrates such as plant cell walls, starch particles and mucin. Examples are emerging from the Firmicutes, Actinobacteria and Verrucomicrobium phyla, but more information is needed on these little studied groups. The impact of dietary carbohydrates, including prebiotics, on human health requires understanding of the complex relationship between diet composition, the gut microbiota and metabolic outputs.",
keywords = "dietary fiber, human intestine, microbiota, nutrition, polysaccharides, prebiotics, resistant starch",
author = "Flint, {Harry J.} and Scott, {Karen P.} and Duncan, {Sylvia H.} and Petra Louis and Evelyne Forano",
year = "2012",
month = "7",
day = "1",
doi = "10.4161/gmic.19897",
language = "English",
volume = "3",
pages = "289--306",
journal = "Gut Microbes",
issn = "1949-0976",
publisher = "Landes Bioscience",
number = "4",

}

TY - JOUR

T1 - Microbial degradation of complex carbohydrates in the gut

AU - Flint, Harry J.

AU - Scott, Karen P.

AU - Duncan, Sylvia H.

AU - Louis, Petra

AU - Forano, Evelyne

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Bacteria that colonize the mammalian intestine collectively possess a far larger repertoire of degradative enzymes and metabolic capabilities than their hosts. Microbial fermentation of complex non-digestible dietary carbohydrates and host-derived glycans in the human intestine has important consequences for health. Certain dominant species, notably among the Bacteroidetes, are known to possess very large numbers of genes that encode carbohydrate active enzymes and can switch readily between different energy sources in the gut depending on availability. Nevertheless, more nutritionally specialized bacteria appear to play critical roles in the community by initiating the degradation of complex substrates such as plant cell walls, starch particles and mucin. Examples are emerging from the Firmicutes, Actinobacteria and Verrucomicrobium phyla, but more information is needed on these little studied groups. The impact of dietary carbohydrates, including prebiotics, on human health requires understanding of the complex relationship between diet composition, the gut microbiota and metabolic outputs.

AB - Bacteria that colonize the mammalian intestine collectively possess a far larger repertoire of degradative enzymes and metabolic capabilities than their hosts. Microbial fermentation of complex non-digestible dietary carbohydrates and host-derived glycans in the human intestine has important consequences for health. Certain dominant species, notably among the Bacteroidetes, are known to possess very large numbers of genes that encode carbohydrate active enzymes and can switch readily between different energy sources in the gut depending on availability. Nevertheless, more nutritionally specialized bacteria appear to play critical roles in the community by initiating the degradation of complex substrates such as plant cell walls, starch particles and mucin. Examples are emerging from the Firmicutes, Actinobacteria and Verrucomicrobium phyla, but more information is needed on these little studied groups. The impact of dietary carbohydrates, including prebiotics, on human health requires understanding of the complex relationship between diet composition, the gut microbiota and metabolic outputs.

KW - dietary fiber

KW - human intestine

KW - microbiota

KW - nutrition

KW - polysaccharides

KW - prebiotics

KW - resistant starch

U2 - 10.4161/gmic.19897

DO - 10.4161/gmic.19897

M3 - Literature review

VL - 3

SP - 289

EP - 306

JO - Gut Microbes

JF - Gut Microbes

SN - 1949-0976

IS - 4

ER -