Microbial PAMP co-stimulation initiates neutrophilic steroid resistant asthma

S. Hadebe, G. Brown, P. Redelinghuys, R. Drummond, K. Fierens, B. Lambrecht, F. Brombacher, F. Kirstein, S. Vautier

Research output: Contribution to journalAbstract

Abstract

Asthma is a complex obstructive airway disease characterised by airway hyper-reactivity to innocuous allergens. It may be categorised as either classical eosinophilic, T helper 2 type of disease or as one driven by neutrophils that may be associated with T helper 17 cells and that is corticosteroid resistant. While the pathogenesis of the disease is not fully understood, there is increasing evidence
for the role of environmentally-derived pathogen-associated molecular patterns (PAMPs) including fungal b-(1,3)-glucans and bacterial lipopolysaccharide (LPS) in inducing and exacerbating airway inflammation
Original languageEnglish
Article number058
Pages (from-to)29
Number of pages1
JournalImmunology
Volume143
Issue numbers1
Early online date8 Oct 2014
DOIs
Publication statusPublished - Oct 2014
Event9th European-Mucosal-Immunology-Group Meeting - Glasgow, United Kingdom
Duration: 1 Oct 2014 → …

Cite this

Hadebe, S., Brown, G., Redelinghuys, P., Drummond, R., Fierens, K., Lambrecht, B., ... Vautier, S. (2014). Microbial PAMP co-stimulation initiates neutrophilic steroid resistant asthma. Immunology, 143(s1), 29. [058]. https://doi.org/10.1111/imm.12384

Microbial PAMP co-stimulation initiates neutrophilic steroid resistant asthma. / Hadebe, S.; Brown, G.; Redelinghuys, P.; Drummond, R.; Fierens, K.; Lambrecht, B.; Brombacher, F.; Kirstein, F.; Vautier, S.

In: Immunology, Vol. 143, No. s1, 058, 10.2014, p. 29.

Research output: Contribution to journalAbstract

Hadebe, S, Brown, G, Redelinghuys, P, Drummond, R, Fierens, K, Lambrecht, B, Brombacher, F, Kirstein, F & Vautier, S 2014, 'Microbial PAMP co-stimulation initiates neutrophilic steroid resistant asthma', Immunology, vol. 143, no. s1, 058, pp. 29. https://doi.org/10.1111/imm.12384
Hadebe S, Brown G, Redelinghuys P, Drummond R, Fierens K, Lambrecht B et al. Microbial PAMP co-stimulation initiates neutrophilic steroid resistant asthma. Immunology. 2014 Oct;143(s1):29. 058. https://doi.org/10.1111/imm.12384
Hadebe, S. ; Brown, G. ; Redelinghuys, P. ; Drummond, R. ; Fierens, K. ; Lambrecht, B. ; Brombacher, F. ; Kirstein, F. ; Vautier, S. / Microbial PAMP co-stimulation initiates neutrophilic steroid resistant asthma. In: Immunology. 2014 ; Vol. 143, No. s1. pp. 29.
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