Microbial PAMP co-stimulation initiates neutrophilic steroid resistant asthma

S. Hadebe, G. Brown, P. Redelinghuys, R. Drummond, K. Fierens, B. Lambrecht, F. Brombacher, F. Kirstein, S. Vautier

Research output: Contribution to journalAbstract

Abstract

Asthma is a complex obstructive airway disease characterised by airway hyper-reactivity to innocuous allergens. It may be categorised as either classical eosinophilic, T helper 2 type of disease or as one driven by neutrophils that may be associated with T helper 17 cells and that is corticosteroid resistant. While the pathogenesis of the disease is not fully understood, there is increasing evidence
for the role of environmentally-derived pathogen-associated molecular patterns (PAMPs) including fungal b-(1,3)-glucans and bacterial lipopolysaccharide (LPS) in inducing and exacerbating airway inflammation
Original languageEnglish
Article number058
Pages (from-to)29
Number of pages1
JournalImmunology
Volume143
Issue numbers1
Early online date8 Oct 2014
DOIs
Publication statusPublished - Oct 2014
Event9th European-Mucosal-Immunology-Group Meeting - Glasgow, United Kingdom
Duration: 1 Oct 2014 → …

Cite this

Hadebe, S., Brown, G., Redelinghuys, P., Drummond, R., Fierens, K., Lambrecht, B., Brombacher, F., Kirstein, F., & Vautier, S. (2014). Microbial PAMP co-stimulation initiates neutrophilic steroid resistant asthma. Immunology, 143(s1), 29. [058]. https://doi.org/10.1111/imm.12384