Microbial PAMP co-stimulation initiates neutrophilic steroid resistant asthma

S. Hadebe; G. Brown; P. Redelinghuys; R. Drummond; K. Fierens; B. Lambrecht; F. Brombacher; F. Kirstein; S. Vautier

doi:10.1111/imm.12384

Microbial PAMP co-stimulation initiates neutrophilic steroid resistant asthma

S. Hadebe, G. Brown, P. Redelinghuys, R. Drummond, K. Fierens, B. Lambrecht, F. Brombacher, F. Kirstein, S. Vautier

Research output: Contribution to journal › Abstract

Abstract

Asthma is a complex obstructive airway disease characterised by airway hyper-reactivity to innocuous allergens. It may be categorised as either classical eosinophilic, T helper 2 type of disease or as one driven by neutrophils that may be associated with T helper 17 cells and that is corticosteroid resistant. While the pathogenesis of the disease is not fully understood, there is increasing evidence
for the role of environmentally-derived pathogen-associated molecular patterns (PAMPs) including fungal b-(1,3)-glucans and bacterial lipopolysaccharide (LPS) in inducing and exacerbating airway inflammation

Original language	English
Article number	058
Pages (from-to)	29
Number of pages	1
Journal	Immunology
Volume	143
Issue number	s1
Early online date	8 Oct 2014
DOIs	https://doi.org/10.1111/imm.12384
Publication status	Published - Oct 2014
Event	9th European-Mucosal-Immunology-Group Meeting - Glasgow, United Kingdom Duration: 1 Oct 2014 → …

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title = "Microbial PAMP co-stimulation initiates neutrophilic steroid resistant asthma",

abstract = "Asthma is a complex obstructive airway disease characterised by airway hyper-reactivity to innocuous allergens. It may be categorised as either classical eosinophilic, T helper 2 type of disease or as one driven by neutrophils that may be associated with T helper 17 cells and that is corticosteroid resistant. While the pathogenesis of the disease is not fully understood, there is increasing evidencefor the role of environmentally-derived pathogen-associated molecular patterns (PAMPs) including fungal b-(1,3)-glucans and bacterial lipopolysaccharide (LPS) in inducing and exacerbating airway inflammation",

author = "S. Hadebe and G. Brown and P. Redelinghuys and R. Drummond and K. Fierens and B. Lambrecht and F. Brombacher and F. Kirstein and S. Vautier",

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T1 - Microbial PAMP co-stimulation initiates neutrophilic steroid resistant asthma

AU - Hadebe, S.

AU - Brown, G.

AU - Redelinghuys, P.

AU - Drummond, R.

AU - Fierens, K.

AU - Lambrecht, B.

AU - Brombacher, F.

AU - Kirstein, F.

AU - Vautier, S.

PY - 2014/10

Y1 - 2014/10

N2 - Asthma is a complex obstructive airway disease characterised by airway hyper-reactivity to innocuous allergens. It may be categorised as either classical eosinophilic, T helper 2 type of disease or as one driven by neutrophils that may be associated with T helper 17 cells and that is corticosteroid resistant. While the pathogenesis of the disease is not fully understood, there is increasing evidencefor the role of environmentally-derived pathogen-associated molecular patterns (PAMPs) including fungal b-(1,3)-glucans and bacterial lipopolysaccharide (LPS) in inducing and exacerbating airway inflammation

AB - Asthma is a complex obstructive airway disease characterised by airway hyper-reactivity to innocuous allergens. It may be categorised as either classical eosinophilic, T helper 2 type of disease or as one driven by neutrophils that may be associated with T helper 17 cells and that is corticosteroid resistant. While the pathogenesis of the disease is not fully understood, there is increasing evidencefor the role of environmentally-derived pathogen-associated molecular patterns (PAMPs) including fungal b-(1,3)-glucans and bacterial lipopolysaccharide (LPS) in inducing and exacerbating airway inflammation

U2 - 10.1111/imm.12384

DO - 10.1111/imm.12384

M3 - Abstract

VL - 143

SP - 29

JO - Immunology

JF - Immunology

SN - 0019-2805

IS - s1

M1 - 058

T2 - 9th European-Mucosal-Immunology-Group Meeting

Y2 - 1 October 2014

ER -

Microbial PAMP co-stimulation initiates neutrophilic steroid resistant asthma

Abstract

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