Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue

Baoguo Li, Li Li, Min Li, Sin Man Lam, Guanlin Wang, Yingga Wu, Hanlin Zhang, Chaoqun Niu, Xueying Zhang, Xue Liu, Catherine Hambly, Wanzhu Jin, Guanghou Shui, John R Speakman

Research output: Contribution to journalArticle

17 Citations (Scopus)
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Abstract

The relation between gut microbiota and the host has been suggested to benefit metabolic homeostasis. Brown adipose tissue (BAT) and beige adipocytes facilitate thermogenesis to maintain host core body temperature during cold exposure. However, the potential impact of gut microbiota on the thermogenic process is confused. Here, we evaluated how BAT and white adipose tissue (WAT) responded to temperature challenges in mice lacking gut microbiota. We found that microbiota depletion via treatment with different cocktails of antibiotics (ABX) or in germ-free (GF) mice impaired the thermogenic capacity of BAT by blunting the increase in the expression of uncoupling protein 1 (UCP1) and reducing the browning process of WAT. Gavage of the bacterial metabolite butyrate increased the thermogenic capacity of ABX-treated mice, reversing the deficit. Our results indicate that gut microbiota contributes to upregulated thermogenesis in the cold environment and that this may be partially mediated via butyrate.

Original languageEnglish
Pages (from-to)2720-2737
Number of pages18
JournalCell Reports
Volume26
Issue number10
Early online date5 Mar 2019
DOIs
Publication statusPublished - 5 Mar 2019

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Keywords

  • brown adipose tissue
  • beige adipocytes
  • brite adipocytes
  • white adipose tissue
  • hermogenesis
  • UCP1
  • gut microbiota
  • butyrate
  • antibiotics
  • germ free mice
  • macrophage
  • IL-4
  • CELLS
  • COMMENSAL BACTERIA
  • CATECHOLAMINES
  • GUT MICROBIOTA
  • DIET-INDUCED OBESITY
  • ALTERNATIVELY ACTIVATED MACROPHAGES
  • ENERGY-EXPENDITURE
  • DEACETYLATION
  • METABOLISM
  • SODIUM-BUTYRATE

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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