Microbiota that affect risk for shigellosis in children in low-income countries

Brianna Lindsay, Joe Oundo, M Anowar Hossain, Martin Antonio, Boubou Tamboura, Alan W Walker, Joseph N Paulson, Julian Parkhill, Richard Omore, Abu S G Faruque, Suman Kumar Das, Usman N Ikumapayi, Mitchell Adeyemi, Doh Sanogo, Debasish Saha, Samba Sow, Tamer H Farag, Dilruba Nasrin, Shan Li, Sandra PanchalingamMyron M Levine, Karen Kotloff, Laurence S Magder, Laura Hungerford, Halvor Sommerfelt, Mihai Pop, James P Nataro, O Colin Stine

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Abstract

Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean 1.4, nondiarrheal mean 0.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% CI 0.17-0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8-220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.-induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene.

Original languageEnglish
Pages (from-to)242-250
Number of pages9
JournalEmerging Infectious Diseases
Volume21
Issue number2
DOIs
Publication statusPublished - Feb 2015

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    Lindsay, B., Oundo, J., Hossain, M. A., Antonio, M., Tamboura, B., Walker, A. W., Paulson, J. N., Parkhill, J., Omore, R., Faruque, A. S. G., Das, S. K., Ikumapayi, U. N., Adeyemi, M., Sanogo, D., Saha, D., Sow, S., Farag, T. H., Nasrin, D., Li, S., ... Stine, O. C. (2015). Microbiota that affect risk for shigellosis in children in low-income countries. Emerging Infectious Diseases, 21(2), 242-250. https://doi.org/10.3201/eid2101.140795