Microbiota that affect risk for shigellosis in children in low-income countries

Brianna Lindsay, Joe Oundo, M Anowar Hossain, Martin Antonio, Boubou Tamboura, Alan W Walker, Joseph N Paulson, Julian Parkhill, Richard Omore, Abu S G Faruque, Suman Kumar Das, Usman N Ikumapayi, Mitchell Adeyemi, Doh Sanogo, Debasish Saha, Samba Sow, Tamer H Farag, Dilruba Nasrin, Shan Li, Sandra Panchalingam & 8 others Myron M Levine, Karen Kotloff, Laurence S Magder, Laura Hungerford, Halvor Sommerfelt, Mihai Pop, James P Nataro, O Colin Stine

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Abstract

Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean 1.4, nondiarrheal mean 0.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% CI 0.17-0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8-220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.-induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene.

Original languageEnglish
Pages (from-to)242-250
Number of pages9
JournalEmerging Infectious Diseases
Volume21
Issue number2
DOIs
Publication statusPublished - Feb 2015

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Bacillary Dysentery
Shigella
Microbiota
Diarrhea
Lactobacillus
Odds Ratio
Escherichia coli Infections
Rotavirus
rRNA Genes
Multicenter Studies
Gastrointestinal Tract
Escherichia coli
Population
Genes
Gastrointestinal Microbiome

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Lindsay, B., Oundo, J., Hossain, M. A., Antonio, M., Tamboura, B., Walker, A. W., ... Stine, O. C. (2015). Microbiota that affect risk for shigellosis in children in low-income countries. Emerging Infectious Diseases, 21(2), 242-250. https://doi.org/10.3201/eid2101.140795

Microbiota that affect risk for shigellosis in children in low-income countries. / Lindsay, Brianna; Oundo, Joe; Hossain, M Anowar; Antonio, Martin; Tamboura, Boubou; Walker, Alan W; Paulson, Joseph N; Parkhill, Julian; Omore, Richard; Faruque, Abu S G; Das, Suman Kumar; Ikumapayi, Usman N; Adeyemi, Mitchell; Sanogo, Doh; Saha, Debasish; Sow, Samba; Farag, Tamer H; Nasrin, Dilruba; Li, Shan; Panchalingam, Sandra; Levine, Myron M; Kotloff, Karen; Magder, Laurence S; Hungerford, Laura; Sommerfelt, Halvor; Pop, Mihai; Nataro, James P; Stine, O Colin.

In: Emerging Infectious Diseases, Vol. 21, No. 2, 02.2015, p. 242-250.

Research output: Contribution to journalArticle

Lindsay, B, Oundo, J, Hossain, MA, Antonio, M, Tamboura, B, Walker, AW, Paulson, JN, Parkhill, J, Omore, R, Faruque, ASG, Das, SK, Ikumapayi, UN, Adeyemi, M, Sanogo, D, Saha, D, Sow, S, Farag, TH, Nasrin, D, Li, S, Panchalingam, S, Levine, MM, Kotloff, K, Magder, LS, Hungerford, L, Sommerfelt, H, Pop, M, Nataro, JP & Stine, OC 2015, 'Microbiota that affect risk for shigellosis in children in low-income countries', Emerging Infectious Diseases, vol. 21, no. 2, pp. 242-250. https://doi.org/10.3201/eid2101.140795
Lindsay, Brianna ; Oundo, Joe ; Hossain, M Anowar ; Antonio, Martin ; Tamboura, Boubou ; Walker, Alan W ; Paulson, Joseph N ; Parkhill, Julian ; Omore, Richard ; Faruque, Abu S G ; Das, Suman Kumar ; Ikumapayi, Usman N ; Adeyemi, Mitchell ; Sanogo, Doh ; Saha, Debasish ; Sow, Samba ; Farag, Tamer H ; Nasrin, Dilruba ; Li, Shan ; Panchalingam, Sandra ; Levine, Myron M ; Kotloff, Karen ; Magder, Laurence S ; Hungerford, Laura ; Sommerfelt, Halvor ; Pop, Mihai ; Nataro, James P ; Stine, O Colin. / Microbiota that affect risk for shigellosis in children in low-income countries. In: Emerging Infectious Diseases. 2015 ; Vol. 21, No. 2. pp. 242-250.
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abstract = "Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean 1.4, nondiarrheal mean 0.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95{\%} CI 0.17-0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95{\%} CI 3.8-220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.-induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene.",
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AU - Lindsay, Brianna

AU - Oundo, Joe

AU - Hossain, M Anowar

AU - Antonio, Martin

AU - Tamboura, Boubou

AU - Walker, Alan W

AU - Paulson, Joseph N

AU - Parkhill, Julian

AU - Omore, Richard

AU - Faruque, Abu S G

AU - Das, Suman Kumar

AU - Ikumapayi, Usman N

AU - Adeyemi, Mitchell

AU - Sanogo, Doh

AU - Saha, Debasish

AU - Sow, Samba

AU - Farag, Tamer H

AU - Nasrin, Dilruba

AU - Li, Shan

AU - Panchalingam, Sandra

AU - Levine, Myron M

AU - Kotloff, Karen

AU - Magder, Laurence S

AU - Hungerford, Laura

AU - Sommerfelt, Halvor

AU - Pop, Mihai

AU - Nataro, James P

AU - Stine, O Colin

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DO - 10.3201/eid2101.140795

M3 - Article

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SP - 242

EP - 250

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

SN - 1080-6040

IS - 2

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