@article{a7cdbf0f985a4cf5b29afd43c0a61179,
title = "Microbiota that affect risk for shigellosis in children in low-income countries",
abstract = "Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean 1.4, nondiarrheal mean 0.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% CI 0.17-0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8-220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.-induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene.",
author = "Brianna Lindsay and Joe Oundo and Hossain, {M Anowar} and Martin Antonio and Boubou Tamboura and Walker, {Alan W} and Paulson, {Joseph N} and Julian Parkhill and Richard Omore and Faruque, {Abu S G} and Das, {Suman Kumar} and Ikumapayi, {Usman N} and Mitchell Adeyemi and Doh Sanogo and Debasish Saha and Samba Sow and Farag, {Tamer H} and Dilruba Nasrin and Shan Li and Sandra Panchalingam and Levine, {Myron M} and Karen Kotloff and Magder, {Laurence S} and Laura Hungerford and Halvor Sommerfelt and Mihai Pop and Nataro, {James P} and Stine, {O Colin}",
note = "Acknowledgements We thank Carol Tackett for her consultation on clinical terminology and readability. B.L., J.P.N., and O.C.S. developed the hypotheses; M.M.L., K.K., and J.P.N. led the Global Enteric Multicenter Study; B.L., J.O., M.A.H., M.A., B.T., R.O., A.S.G.F., S.K.D., U.N.I., M.A., D. Sanogo, D. Saha, S.S., T.H.F., D.N., and S.P. collected data and developed and maintain databases; A.W.W., J.N.P., J.P., M.P., and O.C.S. developed and performed 16S rRNA gene sequencing, assembly, and taxonomic identification; S.L., B.L., and S.P. performed laboratory protocols; and B.L., L.S.M., L.H., and H.S. performed analyses. ",
year = "2015",
month = feb,
doi = "10.3201/eid2101.140795",
language = "English",
volume = "21",
pages = "242--250",
journal = "Emerging Infectious Diseases",
issn = "1080-6040",
publisher = "CENTERS DISEASE CONTROL",
number = "2",
}