Microporosity Affects Bioactivity Of Macroporous Hydroxyapatite Bone Graft Substitutes

K. A. Hing, S. Saeed, Basil Annaz, T. Buckland, P. A. Revell

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    16 Citations (Scopus)

    Abstract

    This paper describes an investigation into the influence of microporosity on early osseointegration within porous hydroxyapatite scaffolds. Two batches of phase pure porous hydroxyapatite were produced with total porosities of approximately 80%, but with varied levels of microporosity such that the strut porosity of the two batches were 10 and 20%. Cylindrical specimens 4.5mm in diameter were implanted in the distal femur of 6 month New Zealand White rabbits and retrieved for histological and histomorphometric analysis at 1 and 3 weeks. Optical microscopy demonstrated variation in the degree of capillary penetration and bone morphology within scaffolds at I and 3 weeks, respectively. Moreover, histomorphometry demonstrated that there was significantly more bone ingrowth within HA80-2 scaffolds and that the rate of bone formation within these scaffolds was significantly faster. These results indicate that the bioactivity of porous hydroxyapatite scaffolds may be improved by increasing the level of microporosity within the ceramic struts.

    Original languageEnglish
    Title of host publicationBioceramics
    Subtitle of host publicationProceedings of the 16th International Symposium on Ceramics in Medicine
    EditorsMario A. Barbosa, Fernanco J. Monteiro, Rui Correia, Betty Leon
    Place of PublicationZurich, Switzerland
    PublisherTrans Tech Publications Ltd
    Pages273-276
    Number of pages3
    Volume16
    ISBN (Print)0878499326, 978-0878499328
    Publication statusPublished - 12 Jan 2004
    Event16th International Symposium on Ceramics in Medicine - Oporto, Portugal
    Duration: 6 Nov 20039 Nov 2003

    Publication series

    NameKey Engineering Materials
    PublisherTrans Tech Publications Ltd
    Number2
    Volume254
    ISSN (Print)1013-9826

    Conference

    Conference16th International Symposium on Ceramics in Medicine
    CountryPortugal
    CityOporto
    Period6/11/039/11/03

    Keywords

    • hydroxyapatite
    • bone graft substitute
    • macroporosity
    • microporosity
    • accelerated osteoconduction

    Cite this

    Hing, K. A., Saeed, S., Annaz, B., Buckland, T., & Revell, P. A. (2004). Microporosity Affects Bioactivity Of Macroporous Hydroxyapatite Bone Graft Substitutes. In M. A. Barbosa, F. J. Monteiro, R. Correia, & B. Leon (Eds.), Bioceramics: Proceedings of the 16th International Symposium on Ceramics in Medicine (Vol. 16, pp. 273-276). (Key Engineering Materials; Vol. 254, No. 2). Trans Tech Publications Ltd.