Midtrimester medical termination of pregnancy: a review of 1002 consecutive cases

Premila Wencesiaus Ashok, Alexander Allan Templeton, Prabhath Thanuja Wagaarachchi, G. M. Flett

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

We assessed the effectiveness, safety and factors that affected the outcome of midtrimester medical termination of pregnancy at 13-21 weeks gestation. Of the 1002 women, 3 took mifepristone and decided to continue with the pregnancy, with 999 women being compliant with the regimen. Of these, 2 women aborted prior to administration of misoprostol and 970 (97.1%) aborted successfully within five doses of misoprostol. Surgical intervention was necessary to complete the abortion process in 81 (8.1%) women. Women with no previous pregnancy (p = 0.02), no previous live birth (p = 0.0001) and gestations 17-21 weeks (p = 0.001) required more prostaglandin. Younger women (p = 0.0001) and women with a previous live birth (p = 0.001) were more likely to have a successful abortion. The induction abortion interval was significantly longer with increasing gestation [95% confidence interval (CI) difference in means: -2.52 to -0.89, p = 0.0001], increasing age (p = 0.0001) and no previous live birth (95% Cl difference in means: -0.25 to -1.01, p = 0.0001). Surgical intervention was more likely to be required with increasing age (p = 0.008). Mifepristone in combination with misoprostol is a safe and effective regimen for midtrimester medical abortion with younger women and those with a previous live birth more likely to have a successful abortion. (C) 2004 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)51-58
Number of pages7
JournalContraception
Volume69
Issue number1
DOIs
Publication statusPublished - 2004

Keywords

  • mifepristone
  • misoprostol
  • midtrimester medical abortion
  • 2ND TRIMESTER ABORTION
  • MIFEPRISTONE RU-486
  • 2ND-TRIMESTER PREGNANCY
  • VAGINAL MISOPROSTOL
  • GEMEPROST
  • INDUCTION
  • REGIMENS

Cite this