Abstract
We assessed the effectiveness, safety and factors that affected the outcome of midtrimester medical termination of pregnancy at 13-21 weeks gestation. Of the 1002 women, 3 took mifepristone and decided to continue with the pregnancy, with 999 women being compliant with the regimen. Of these, 2 women aborted prior to administration of misoprostol and 970 (97.1%) aborted successfully within five doses of misoprostol. Surgical intervention was necessary to complete the abortion process in 81 (8.1%) women. Women with no previous pregnancy (p = 0.02), no previous live birth (p = 0.0001) and gestations 17-21 weeks (p = 0.001) required more prostaglandin. Younger women (p = 0.0001) and women with a previous live birth (p = 0.001) were more likely to have a successful abortion. The induction abortion interval was significantly longer with increasing gestation [95% confidence interval (CI) difference in means: -2.52 to -0.89, p = 0.0001], increasing age (p = 0.0001) and no previous live birth (95% Cl difference in means: -0.25 to -1.01, p = 0.0001). Surgical intervention was more likely to be required with increasing age (p = 0.008). Mifepristone in combination with misoprostol is a safe and effective regimen for midtrimester medical abortion with younger women and those with a previous live birth more likely to have a successful abortion. (C) 2004 Elsevier Inc. All rights reserved.
Original language | English |
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Pages (from-to) | 51-58 |
Number of pages | 7 |
Journal | Contraception |
Volume | 69 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2004 |
Keywords
- mifepristone
- misoprostol
- midtrimester medical abortion
- 2ND TRIMESTER ABORTION
- MIFEPRISTONE RU-486
- 2ND-TRIMESTER PREGNANCY
- VAGINAL MISOPROSTOL
- GEMEPROST
- INDUCTION
- REGIMENS