Miniature Untethered EEG Recorder Improves Advanced Neuroscience Methodologies

Christopher Crispin-Bailey* (Corresponding Author), Jim Austin, Bettina Platt* (Corresponding Author), Anthony Moulds, Barry Crouch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
3 Downloads (Pure)


Rodent electroencephalography (EEG) in preclinical research is frequently conducted in behaving animals. However, the difficulty inherent in identifying EEG epochs associated with a particular behavior or cue is a significant obstacle to more efficient analysis. In this paper we highlight a new solution, using infrared event stamping to accurately synchronize EEG, recorded from superficial sites above the hippocampus and prefrontal cortex, with video motion tracking data in a transgenic Alzheimer’s disease (AD) mouse model. Epochs capturing specific behaviors were automatically identified and extracted prior to further analysis. This was achieved by the novel design of a ultraminiature wearable EEG recorder, the NAT-1 device, and its insitu IR recording module. The device is described in detail, and its contribution to enabling new neuroscience is demonstrated.
Original languageEnglish
Pages (from-to)1101-1111
Number of pages11
JournalIEEE Transactions on Biomedical Circuits and Systems
Issue number5
Early online date14 Aug 2019
Publication statusPublished - Oct 2019


  • Experimental neuroscience
  • EEG recording
  • low-power sensors


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