Minimal access surgery for cholelithiasis induces an attenuated acute phase response

D M Bruce, M Smith, C B J Walker, S D Heys, N R Binnie, D B Gough, J Broom, O Eremin

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

BACKGROUND: Some benefits of laparoscopic (LC) and minilaparotomy (NIC) cholecystectomy may reflect attenuation of the acute phase response. The authors examined components of this response.

METHODS: Patients were randomized to LC (n = 11) or MC (n = II). C-reactive protein (CRP), alpha-1-antitrypsin (AAT), retinol-binding protein (RBP), transferrin, and albumin were measured preoperatively and on postoperative days 1, 2, 4, and 7. Interleukin-1 receptor antagonist (IL-1ra), IL-6, and tumor necrosis factor (TNF-alpha) were measured more frequently perioperatively. Peak expiratory flow rate, forced expiratory volume in 1 second, and forced vital capacity were measured daily.

RESULTS: The IL-6 increase was more persistent and marked in the MC patients from hour 8 to day 7 postoperatively (P < 0.05). Alterations in CRP, AAT, and albumin were similar, Postoperative deficits of respiratory function correlated with the magnitude of acute phase protein alteration.

CONCLUSIONS: Minimal access surgery induces an acute phase response that is less prominent after a laparoscopic technique. (C) 1999 by Excerpta Medica, Inc.

Original languageEnglish
Pages (from-to)232-234
Number of pages3
JournalAmerican Journal of Surgery
Volume178
Publication statusPublished - 1999

Keywords

  • CHOLECYSTECTOMY
  • INCISION

Cite this

Bruce, D. M., Smith, M., Walker, C. B. J., Heys, S. D., Binnie, N. R., Gough, D. B., ... Eremin, O. (1999). Minimal access surgery for cholelithiasis induces an attenuated acute phase response. American Journal of Surgery, 178, 232-234.

Minimal access surgery for cholelithiasis induces an attenuated acute phase response. / Bruce, D M ; Smith, M ; Walker, C B J ; Heys, S D ; Binnie, N R ; Gough, D B ; Broom, J ; Eremin, O .

In: American Journal of Surgery, Vol. 178, 1999, p. 232-234.

Research output: Contribution to journalArticle

Bruce, DM, Smith, M, Walker, CBJ, Heys, SD, Binnie, NR, Gough, DB, Broom, J & Eremin, O 1999, 'Minimal access surgery for cholelithiasis induces an attenuated acute phase response', American Journal of Surgery, vol. 178, pp. 232-234.
Bruce DM, Smith M, Walker CBJ, Heys SD, Binnie NR, Gough DB et al. Minimal access surgery for cholelithiasis induces an attenuated acute phase response. American Journal of Surgery. 1999;178:232-234.
Bruce, D M ; Smith, M ; Walker, C B J ; Heys, S D ; Binnie, N R ; Gough, D B ; Broom, J ; Eremin, O . / Minimal access surgery for cholelithiasis induces an attenuated acute phase response. In: American Journal of Surgery. 1999 ; Vol. 178. pp. 232-234.
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abstract = "BACKGROUND: Some benefits of laparoscopic (LC) and minilaparotomy (NIC) cholecystectomy may reflect attenuation of the acute phase response. The authors examined components of this response.METHODS: Patients were randomized to LC (n = 11) or MC (n = II). C-reactive protein (CRP), alpha-1-antitrypsin (AAT), retinol-binding protein (RBP), transferrin, and albumin were measured preoperatively and on postoperative days 1, 2, 4, and 7. Interleukin-1 receptor antagonist (IL-1ra), IL-6, and tumor necrosis factor (TNF-alpha) were measured more frequently perioperatively. Peak expiratory flow rate, forced expiratory volume in 1 second, and forced vital capacity were measured daily.RESULTS: The IL-6 increase was more persistent and marked in the MC patients from hour 8 to day 7 postoperatively (P < 0.05). Alterations in CRP, AAT, and albumin were similar, Postoperative deficits of respiratory function correlated with the magnitude of acute phase protein alteration.CONCLUSIONS: Minimal access surgery induces an acute phase response that is less prominent after a laparoscopic technique. (C) 1999 by Excerpta Medica, Inc.",
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T1 - Minimal access surgery for cholelithiasis induces an attenuated acute phase response

AU - Bruce, D M

AU - Smith, M

AU - Walker, C B J

AU - Heys, S D

AU - Binnie, N R

AU - Gough, D B

AU - Broom, J

AU - Eremin, O

PY - 1999

Y1 - 1999

N2 - BACKGROUND: Some benefits of laparoscopic (LC) and minilaparotomy (NIC) cholecystectomy may reflect attenuation of the acute phase response. The authors examined components of this response.METHODS: Patients were randomized to LC (n = 11) or MC (n = II). C-reactive protein (CRP), alpha-1-antitrypsin (AAT), retinol-binding protein (RBP), transferrin, and albumin were measured preoperatively and on postoperative days 1, 2, 4, and 7. Interleukin-1 receptor antagonist (IL-1ra), IL-6, and tumor necrosis factor (TNF-alpha) were measured more frequently perioperatively. Peak expiratory flow rate, forced expiratory volume in 1 second, and forced vital capacity were measured daily.RESULTS: The IL-6 increase was more persistent and marked in the MC patients from hour 8 to day 7 postoperatively (P < 0.05). Alterations in CRP, AAT, and albumin were similar, Postoperative deficits of respiratory function correlated with the magnitude of acute phase protein alteration.CONCLUSIONS: Minimal access surgery induces an acute phase response that is less prominent after a laparoscopic technique. (C) 1999 by Excerpta Medica, Inc.

AB - BACKGROUND: Some benefits of laparoscopic (LC) and minilaparotomy (NIC) cholecystectomy may reflect attenuation of the acute phase response. The authors examined components of this response.METHODS: Patients were randomized to LC (n = 11) or MC (n = II). C-reactive protein (CRP), alpha-1-antitrypsin (AAT), retinol-binding protein (RBP), transferrin, and albumin were measured preoperatively and on postoperative days 1, 2, 4, and 7. Interleukin-1 receptor antagonist (IL-1ra), IL-6, and tumor necrosis factor (TNF-alpha) were measured more frequently perioperatively. Peak expiratory flow rate, forced expiratory volume in 1 second, and forced vital capacity were measured daily.RESULTS: The IL-6 increase was more persistent and marked in the MC patients from hour 8 to day 7 postoperatively (P < 0.05). Alterations in CRP, AAT, and albumin were similar, Postoperative deficits of respiratory function correlated with the magnitude of acute phase protein alteration.CONCLUSIONS: Minimal access surgery induces an acute phase response that is less prominent after a laparoscopic technique. (C) 1999 by Excerpta Medica, Inc.

KW - CHOLECYSTECTOMY

KW - INCISION

M3 - Article

VL - 178

SP - 232

EP - 234

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

ER -