Minimal access surgery for cholelithiasis induces an attenuated acute phase response

D M  Bruce; M  Smith; C B J  Walker; S D  Heys; N R  Binnie; D B  Gough; J  Broom; O  Eremin

Minimal access surgery for cholelithiasis induces an attenuated acute phase response

D M Bruce, M Smith, C B J Walker, S D Heys, N R Binnie, D B Gough, J Broom, O Eremin

Applied Medicine

Research output: Contribution to journal › Article

48 Citations (Scopus)

Abstract

BACKGROUND: Some benefits of laparoscopic (LC) and minilaparotomy (NIC) cholecystectomy may reflect attenuation of the acute phase response. The authors examined components of this response.

METHODS: Patients were randomized to LC (n = 11) or MC (n = II). C-reactive protein (CRP), alpha-1-antitrypsin (AAT), retinol-binding protein (RBP), transferrin, and albumin were measured preoperatively and on postoperative days 1, 2, 4, and 7. Interleukin-1 receptor antagonist (IL-1ra), IL-6, and tumor necrosis factor (TNF-alpha) were measured more frequently perioperatively. Peak expiratory flow rate, forced expiratory volume in 1 second, and forced vital capacity were measured daily.

RESULTS: The IL-6 increase was more persistent and marked in the MC patients from hour 8 to day 7 postoperatively (P < 0.05). Alterations in CRP, AAT, and albumin were similar, Postoperative deficits of respiratory function correlated with the magnitude of acute phase protein alteration.

Original language	English
Pages (from-to)	232-234
Number of pages	3
Journal	American Journal of Surgery
Volume	178
Publication status	Published - 1999

Keywords

CHOLECYSTECTOMY
INCISION

Cite this

@article{de9e26339d514228b03aa32ef86c3495,

title = "Minimal access surgery for cholelithiasis induces an attenuated acute phase response",

abstract = "BACKGROUND: Some benefits of laparoscopic (LC) and minilaparotomy (NIC) cholecystectomy may reflect attenuation of the acute phase response. The authors examined components of this response.METHODS: Patients were randomized to LC (n = 11) or MC (n = II). C-reactive protein (CRP), alpha-1-antitrypsin (AAT), retinol-binding protein (RBP), transferrin, and albumin were measured preoperatively and on postoperative days 1, 2, 4, and 7. Interleukin-1 receptor antagonist (IL-1ra), IL-6, and tumor necrosis factor (TNF-alpha) were measured more frequently perioperatively. Peak expiratory flow rate, forced expiratory volume in 1 second, and forced vital capacity were measured daily.RESULTS: The IL-6 increase was more persistent and marked in the MC patients from hour 8 to day 7 postoperatively (P < 0.05). Alterations in CRP, AAT, and albumin were similar, Postoperative deficits of respiratory function correlated with the magnitude of acute phase protein alteration.CONCLUSIONS: Minimal access surgery induces an acute phase response that is less prominent after a laparoscopic technique. (C) 1999 by Excerpta Medica, Inc.",

keywords = "CHOLECYSTECTOMY, INCISION",

author = "Bruce, {D M} and M Smith and Walker, {C B J} and Heys, {S D} and Binnie, {N R} and Gough, {D B} and J Broom and O Eremin",

year = "1999",

language = "English",

volume = "178",

pages = "232--234",

journal = "American Journal of Surgery",

issn = "0002-9610",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Minimal access surgery for cholelithiasis induces an attenuated acute phase response

AU - Bruce, D M

AU - Smith, M

AU - Walker, C B J

AU - Heys, S D

AU - Binnie, N R

AU - Gough, D B

AU - Broom, J

AU - Eremin, O

PY - 1999

Y1 - 1999

N2 - BACKGROUND: Some benefits of laparoscopic (LC) and minilaparotomy (NIC) cholecystectomy may reflect attenuation of the acute phase response. The authors examined components of this response.METHODS: Patients were randomized to LC (n = 11) or MC (n = II). C-reactive protein (CRP), alpha-1-antitrypsin (AAT), retinol-binding protein (RBP), transferrin, and albumin were measured preoperatively and on postoperative days 1, 2, 4, and 7. Interleukin-1 receptor antagonist (IL-1ra), IL-6, and tumor necrosis factor (TNF-alpha) were measured more frequently perioperatively. Peak expiratory flow rate, forced expiratory volume in 1 second, and forced vital capacity were measured daily.RESULTS: The IL-6 increase was more persistent and marked in the MC patients from hour 8 to day 7 postoperatively (P < 0.05). Alterations in CRP, AAT, and albumin were similar, Postoperative deficits of respiratory function correlated with the magnitude of acute phase protein alteration.CONCLUSIONS: Minimal access surgery induces an acute phase response that is less prominent after a laparoscopic technique. (C) 1999 by Excerpta Medica, Inc.

AB - BACKGROUND: Some benefits of laparoscopic (LC) and minilaparotomy (NIC) cholecystectomy may reflect attenuation of the acute phase response. The authors examined components of this response.METHODS: Patients were randomized to LC (n = 11) or MC (n = II). C-reactive protein (CRP), alpha-1-antitrypsin (AAT), retinol-binding protein (RBP), transferrin, and albumin were measured preoperatively and on postoperative days 1, 2, 4, and 7. Interleukin-1 receptor antagonist (IL-1ra), IL-6, and tumor necrosis factor (TNF-alpha) were measured more frequently perioperatively. Peak expiratory flow rate, forced expiratory volume in 1 second, and forced vital capacity were measured daily.RESULTS: The IL-6 increase was more persistent and marked in the MC patients from hour 8 to day 7 postoperatively (P < 0.05). Alterations in CRP, AAT, and albumin were similar, Postoperative deficits of respiratory function correlated with the magnitude of acute phase protein alteration.CONCLUSIONS: Minimal access surgery induces an acute phase response that is less prominent after a laparoscopic technique. (C) 1999 by Excerpta Medica, Inc.

KW - CHOLECYSTECTOMY

KW - INCISION

M3 - Article

SN - 0002-9610

VL - 178

SP - 232

EP - 234

JO - American Journal of Surgery

JF - American Journal of Surgery

ER -

Minimal access surgery for cholelithiasis induces an attenuated acute phase response

Abstract

Keywords

Fingerprint

Cite this