Fundamental biological processes such as transcription and translation, where a genetic sequence is sequentially read by a macromolecule, have been well described by a classical model of nonequilibrium statistical physics, the totally asymmetric exclusion principle (TASEP). This model describes particles hopping between sites of a one-dimensional lattice, with the particle current determining the transcription or translation rate. An open problem is how to analyze a TASEP where particles can pause randomly, as has been observed during transcription. In this work, we report that surprisingly, a simple mean-field model predicts well the particle current for all values of the average pause duration, using a simple description of blocking behind paused particles.
|Number of pages||4|
|Journal||Physical Review. E, Statistical, Nonlinear and Soft Matter Physics|
|Publication status||Published - 11 Nov 2014|
Wang, J., Pfeuty, B., Thommen, Q., Romano Blasco, M. C., & Lefranc, M. (2014). Minimal model of transcriptional elongation processes with pauses. Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, 90(5), 1-4. . https://doi.org/10.1103/PhysRevE.90.050701