Minimal model of transcriptional elongation processes with pauses

Jingkui Wang, Benjamin Pfeuty, Quentin Thommen, M. Carmen Romano Blasco, Marc Lefranc

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Fundamental biological processes such as transcription and translation, where a genetic sequence is sequentially read by a macromolecule, have been well described by a classical model of nonequilibrium statistical physics, the totally asymmetric exclusion principle (TASEP). This model describes particles hopping between sites of a one-dimensional lattice, with the particle current determining the transcription or translation rate. An open problem is how to analyze a TASEP where particles can pause randomly, as has been observed during transcription. In this work, we report that surprisingly, a simple mean-field model predicts well the particle current for all values of the average pause duration, using a simple description of blocking behind paused particles.
Original languageEnglish
Article number050701
Pages (from-to)1-4
Number of pages4
JournalPhysical Review. E, Statistical, Nonlinear and Soft Matter Physics
Volume90
Issue number5
DOIs
Publication statusPublished - 11 Nov 2014

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Minimal Model
Elongation
elongation
Transcription
exclusion
Mean-field Model
Statistical Physics
macromolecules
Non-equilibrium
Open Problems
Predict
physics
Model

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Minimal model of transcriptional elongation processes with pauses. / Wang, Jingkui; Pfeuty, Benjamin; Thommen, Quentin; Romano Blasco, M. Carmen; Lefranc, Marc.

In: Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, Vol. 90, No. 5, 050701, 11.11.2014, p. 1-4.

Research output: Contribution to journalArticle

Wang, Jingkui ; Pfeuty, Benjamin ; Thommen, Quentin ; Romano Blasco, M. Carmen ; Lefranc, Marc. / Minimal model of transcriptional elongation processes with pauses. In: Physical Review. E, Statistical, Nonlinear and Soft Matter Physics. 2014 ; Vol. 90, No. 5. pp. 1-4.
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