Abstract
| Original language | English |
|---|---|
| Article number | 050701 |
| Pages (from-to) | 1-4 |
| Number of pages | 4 |
| Journal | Physical Review. E, Statistical, Nonlinear and Soft Matter Physics |
| Volume | 90 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 11 Nov 2014 |
Fingerprint
Cite this
Minimal model of transcriptional elongation processes with pauses. / Wang, Jingkui; Pfeuty, Benjamin; Thommen, Quentin; Romano Blasco, M. Carmen; Lefranc, Marc.
In: Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, Vol. 90, No. 5, 050701, 11.11.2014, p. 1-4.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Minimal model of transcriptional elongation processes with pauses
AU - Wang, Jingkui
AU - Pfeuty, Benjamin
AU - Thommen, Quentin
AU - Romano Blasco, M. Carmen
AU - Lefranc, Marc
N1 - M.C.R. is funded by Biotechnology and Biological Sciences Research Council (BB/F00513/X1) and SULSA, and acknowledges a Visiting Professorship at Universite Lille 1 ´ in June 2012. This work has been partially supported by Ministry of Higher Education and Research, Nord-Pas de Calais Regional Council and European Regional Development Fund (ERDF) through the Contrat de Projets Etat-R ´ egion ´ (CPER) 2007–2013, as well as by the Agence Nationale de la Recherche through the LABEX CEMPI project (ANR-11- LABX-0007).
PY - 2014/11/11
Y1 - 2014/11/11
N2 - Fundamental biological processes such as transcription and translation, where a genetic sequence is sequentially read by a macromolecule, have been well described by a classical model of nonequilibrium statistical physics, the totally asymmetric exclusion principle (TASEP). This model describes particles hopping between sites of a one-dimensional lattice, with the particle current determining the transcription or translation rate. An open problem is how to analyze a TASEP where particles can pause randomly, as has been observed during transcription. In this work, we report that surprisingly, a simple mean-field model predicts well the particle current for all values of the average pause duration, using a simple description of blocking behind paused particles.
AB - Fundamental biological processes such as transcription and translation, where a genetic sequence is sequentially read by a macromolecule, have been well described by a classical model of nonequilibrium statistical physics, the totally asymmetric exclusion principle (TASEP). This model describes particles hopping between sites of a one-dimensional lattice, with the particle current determining the transcription or translation rate. An open problem is how to analyze a TASEP where particles can pause randomly, as has been observed during transcription. In this work, we report that surprisingly, a simple mean-field model predicts well the particle current for all values of the average pause duration, using a simple description of blocking behind paused particles.
U2 - 10.1103/PhysRevE.90.050701
DO - 10.1103/PhysRevE.90.050701
M3 - Article
VL - 90
SP - 1
EP - 4
JO - Physical Review. E, Statistical, Nonlinear and Soft Matter Physics
JF - Physical Review. E, Statistical, Nonlinear and Soft Matter Physics
SN - 1539-3755
IS - 5
M1 - 050701
ER -