Minimal modulation of lymphocyte and natural killer cell subsets following minimal access surgery

C B J Walker, D M Bruce, S D Heys, D B Gough, N R Binnie, O Eremin

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

BACKGROUND: Trauma, whether accidental or surgically induced, is known to cause significant modulation of the cell-mediated immune response. Minimal access surgery (MAS) has been shown to improve postoperative recovery and enhance rehabilitation. The degree of immunosuppression resulting from two MAS techniques was studied and compared by measuring the circulating T lymphocyte and natural killer (NK) cell subsets.

METHOD: This investigation was a randomized prospective study of patients admitted to the Professorial Surgical Unit, Aberdeen Royal Infirmary for elective cholecystectomy. Two methods of MAS were studied-laparoscopy and mini-laparotomy,

RESULTS: Laparoscopy was found to cause significantly less reduction in the number of cells expressing T lymphocyte phenotypic surface markers (CD2, CD3, CD8, CD4:CD8 ratio), activation markers (CD71 and HLA-DR), and NK cell subsets (CD11b, CD16, CD56 and CD57), when compared with the minilaparotomy technique.

CONCLUSIONS: These data show that host defences are less suppressed after laparoscopic cholecystectomy, and this may have important implications for the use of laparoscopic techniques in major surgical resections, especially for malignant disease. Am J Surg. 1999;177:48-54, (C) 1999 by Excerpta Medica, Inc.

Original languageEnglish
Pages (from-to)48-54
Number of pages7
JournalAmerican Journal of Surgery
Volume177
Publication statusPublished - 1999

Keywords

  • LAPAROSCOPIC CHOLECYSTECTOMY
  • MINILAPAROTOMY CHOLECYSTECTOMY
  • RANDOMIZED TRIAL
  • INFLAMMATORY RESPONSES
  • IMMUNE-RESPONSE
  • TRAUMA

Cite this

Walker, C. B. J., Bruce, D. M., Heys, S. D., Gough, D. B., Binnie, N. R., & Eremin, O. (1999). Minimal modulation of lymphocyte and natural killer cell subsets following minimal access surgery. American Journal of Surgery, 177, 48-54.

Minimal modulation of lymphocyte and natural killer cell subsets following minimal access surgery. / Walker, C B J ; Bruce, D M ; Heys, S D ; Gough, D B ; Binnie, N R ; Eremin, O .

In: American Journal of Surgery, Vol. 177, 1999, p. 48-54.

Research output: Contribution to journalArticle

Walker, CBJ, Bruce, DM, Heys, SD, Gough, DB, Binnie, NR & Eremin, O 1999, 'Minimal modulation of lymphocyte and natural killer cell subsets following minimal access surgery', American Journal of Surgery, vol. 177, pp. 48-54.
Walker, C B J ; Bruce, D M ; Heys, S D ; Gough, D B ; Binnie, N R ; Eremin, O . / Minimal modulation of lymphocyte and natural killer cell subsets following minimal access surgery. In: American Journal of Surgery. 1999 ; Vol. 177. pp. 48-54.
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T1 - Minimal modulation of lymphocyte and natural killer cell subsets following minimal access surgery

AU - Walker, C B J

AU - Bruce, D M

AU - Heys, S D

AU - Gough, D B

AU - Binnie, N R

AU - Eremin, O

PY - 1999

Y1 - 1999

N2 - BACKGROUND: Trauma, whether accidental or surgically induced, is known to cause significant modulation of the cell-mediated immune response. Minimal access surgery (MAS) has been shown to improve postoperative recovery and enhance rehabilitation. The degree of immunosuppression resulting from two MAS techniques was studied and compared by measuring the circulating T lymphocyte and natural killer (NK) cell subsets.METHOD: This investigation was a randomized prospective study of patients admitted to the Professorial Surgical Unit, Aberdeen Royal Infirmary for elective cholecystectomy. Two methods of MAS were studied-laparoscopy and mini-laparotomy,RESULTS: Laparoscopy was found to cause significantly less reduction in the number of cells expressing T lymphocyte phenotypic surface markers (CD2, CD3, CD8, CD4:CD8 ratio), activation markers (CD71 and HLA-DR), and NK cell subsets (CD11b, CD16, CD56 and CD57), when compared with the minilaparotomy technique.CONCLUSIONS: These data show that host defences are less suppressed after laparoscopic cholecystectomy, and this may have important implications for the use of laparoscopic techniques in major surgical resections, especially for malignant disease. Am J Surg. 1999;177:48-54, (C) 1999 by Excerpta Medica, Inc.

AB - BACKGROUND: Trauma, whether accidental or surgically induced, is known to cause significant modulation of the cell-mediated immune response. Minimal access surgery (MAS) has been shown to improve postoperative recovery and enhance rehabilitation. The degree of immunosuppression resulting from two MAS techniques was studied and compared by measuring the circulating T lymphocyte and natural killer (NK) cell subsets.METHOD: This investigation was a randomized prospective study of patients admitted to the Professorial Surgical Unit, Aberdeen Royal Infirmary for elective cholecystectomy. Two methods of MAS were studied-laparoscopy and mini-laparotomy,RESULTS: Laparoscopy was found to cause significantly less reduction in the number of cells expressing T lymphocyte phenotypic surface markers (CD2, CD3, CD8, CD4:CD8 ratio), activation markers (CD71 and HLA-DR), and NK cell subsets (CD11b, CD16, CD56 and CD57), when compared with the minilaparotomy technique.CONCLUSIONS: These data show that host defences are less suppressed after laparoscopic cholecystectomy, and this may have important implications for the use of laparoscopic techniques in major surgical resections, especially for malignant disease. Am J Surg. 1999;177:48-54, (C) 1999 by Excerpta Medica, Inc.

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KW - IMMUNE-RESPONSE

KW - TRAUMA

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JO - American Journal of Surgery

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