Mitotic Golgi partitioning is driven by the membrane-fissioning protein CtBP3/BARS

Cristina Hidalgo Carcedo, Matteo Bonazzi, Stefania Spanò, Gabriele Turacchio, Antonino Colanzi, Alberto Luini, Daniela Corda

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Organelle inheritance is an essential feature of all eukaryotic cells. As with other organelles, the Golgi complex partitions between daughter cells through the fission of its membranes into numerous tubulovesicular fragments. We found that the protein CtBP3/BARS (BARS) was responsible for driving the fission of Golgi membranes during mitosis in vivo. Moreover, by in vitro analysis, we identified two stages of this Golgi fragmentation process: disassembly of the Golgi stacks into a tubular network, and BARS-dependent fission of these tubules. Finally, this BARS-induced fission of Golgi membranes controlled the G2-to-prophase transition of the cell cycle, and hence cell division.
Original languageEnglish
Pages (from-to)93-6
Number of pages4
JournalScience
Volume305
Issue number5680
DOIs
Publication statusPublished - 2 Jul 2004

Keywords

  • Animals
  • Carrier Proteins
  • Cell Line
  • Cytosol
  • G2 Phase
  • Golgi Apparatus
  • Interphase
  • Intracellular Membranes
  • Mitosis
  • Oligonucleotides, Antisense
  • Protein Structure, Tertiary
  • Rats
  • Recombinant Proteins
  • Transcription Factors

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  • Cite this

    Hidalgo Carcedo, C., Bonazzi, M., Spanò, S., Turacchio, G., Colanzi, A., Luini, A., & Corda, D. (2004). Mitotic Golgi partitioning is driven by the membrane-fissioning protein CtBP3/BARS. Science, 305(5680), 93-6. https://doi.org/10.1126/science.1097775