Mixed Candida albicans strain populations in colonized and infected mucosal tissues

Mette D. Jacobsen, Amanda D. Duncan, Judith Margaret Bain, Elizabeth M. Johnson, Julian R. Naglik, Duncan J. Shaw, Neil A. R. Gow, Frank Christopher Odds

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Multilocus sequence typing of six Candida albicans colonies from primary isolation plates revealed instances of colony-to-colony microvariation and carriage of two strain types in single oropharyngeal and vaginal samples. Higher rates of colony variation in commensal samples suggest selection of types from mixed populations either in the shift to pathogenicity or the response to antifungal treatment.

Original languageEnglish
Pages (from-to)1334-1338
Number of pages5
JournalFEMS Yeast Research
Volume8
Issue number8
Early online date15 Sep 2008
DOIs
Publication statusPublished - Dec 2008

Keywords

  • Candida albicans
  • MLST
  • strain typing
  • epidemiology
  • drug-resistance
  • microevolutionary changes
  • phenotypic diversity
  • evolution
  • replacement
  • single

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