Mixed Candida albicans strain populations in colonized and infected mucosal tissues

Mette D. Jacobsen; Amanda D. Duncan; Judith Margaret Bain; Elizabeth M. Johnson; Julian R. Naglik; Duncan J. Shaw; Neil A. R. Gow; Frank Christopher Odds

doi:10.1111/j.1567-1364.2008.00438.x

Mixed Candida albicans strain populations in colonized and infected mucosal tissues

Mette D. Jacobsen, Amanda D. Duncan, Judith Margaret Bain, Elizabeth M. Johnson, Julian R. Naglik, Duncan J. Shaw, Neil A. R. Gow, Frank Christopher Odds

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Multilocus sequence typing of six Candida albicans colonies from primary isolation plates revealed instances of colony-to-colony microvariation and carriage of two strain types in single oropharyngeal and vaginal samples. Higher rates of colony variation in commensal samples suggest selection of types from mixed populations either in the shift to pathogenicity or the response to antifungal treatment.

Original language	English
Pages (from-to)	1334-1338
Number of pages	5
Journal	FEMS Yeast Research
Volume	8
Issue number	8
Early online date	15 Sept 2008
DOIs	https://doi.org/10.1111/j.1567-1364.2008.00438.x
Publication status	Published - Dec 2008

Keywords

Candida albicans
MLST
strain typing
epidemiology
drug-resistance
microevolutionary changes
phenotypic diversity
evolution
replacement
single

Access to Document

10.1111/j.1567-1364.2008.00438.x

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667310/

Cite this

@article{588c521a0efd4dd5a3300dbf9e4a9b0c,

title = "Mixed Candida albicans strain populations in colonized and infected mucosal tissues",

abstract = "Multilocus sequence typing of six Candida albicans colonies from primary isolation plates revealed instances of colony-to-colony microvariation and carriage of two strain types in single oropharyngeal and vaginal samples. Higher rates of colony variation in commensal samples suggest selection of types from mixed populations either in the shift to pathogenicity or the response to antifungal treatment.",

keywords = "Candida albicans, MLST, strain typing, epidemiology, drug-resistance, microevolutionary changes, phenotypic diversity, evolution, replacement, single",

author = "Jacobsen, {Mette D.} and Duncan, {Amanda D.} and Bain, {Judith Margaret} and Johnson, {Elizabeth M.} and Naglik, {Julian R.} and Shaw, {Duncan J.} and Gow, {Neil A. R.} and Odds, {Frank Christopher}",

year = "2008",

month = dec,

doi = "10.1111/j.1567-1364.2008.00438.x",

language = "English",

volume = "8",

pages = "1334--1338",

journal = "FEMS Yeast Research",

issn = "1567-1356",

publisher = "OXFORD UNIV PRESS",

number = "8",

}

TY - JOUR

T1 - Mixed Candida albicans strain populations in colonized and infected mucosal tissues

AU - Jacobsen, Mette D.

AU - Duncan, Amanda D.

AU - Bain, Judith Margaret

AU - Johnson, Elizabeth M.

AU - Naglik, Julian R.

AU - Shaw, Duncan J.

AU - Gow, Neil A. R.

AU - Odds, Frank Christopher

PY - 2008/12

Y1 - 2008/12

N2 - Multilocus sequence typing of six Candida albicans colonies from primary isolation plates revealed instances of colony-to-colony microvariation and carriage of two strain types in single oropharyngeal and vaginal samples. Higher rates of colony variation in commensal samples suggest selection of types from mixed populations either in the shift to pathogenicity or the response to antifungal treatment.

AB - Multilocus sequence typing of six Candida albicans colonies from primary isolation plates revealed instances of colony-to-colony microvariation and carriage of two strain types in single oropharyngeal and vaginal samples. Higher rates of colony variation in commensal samples suggest selection of types from mixed populations either in the shift to pathogenicity or the response to antifungal treatment.

KW - Candida albicans

KW - MLST

KW - strain typing

KW - epidemiology

KW - drug-resistance

KW - microevolutionary changes

KW - phenotypic diversity

KW - evolution

KW - replacement

KW - single

U2 - 10.1111/j.1567-1364.2008.00438.x

DO - 10.1111/j.1567-1364.2008.00438.x

M3 - Article

SN - 1567-1356

VL - 8

SP - 1334

EP - 1338

JO - FEMS Yeast Research

JF - FEMS Yeast Research

IS - 8

ER -

Mixed Candida albicans strain populations in colonized and infected mucosal tissues

Abstract

Keywords

Access to Document

Fingerprint

Cite this