efficient execution of cell death signalling is the desirable fate of cancer chemotherapy, and therefore the need to identify novel compounds with better apoptotic potential. Over the years, our laboratory has been studying the mechanism(s) underlying resistance to death signalling in tumour cell with the ultimate goal of identifying druggable targets for enhancing the efficacy of cancer chemotherapy.
Lee, S. F., Yadav, S. K., Oh, C. H., Hirpara, J. L., Holme, A. L., & Pervaiz, S. (2006). Mlecular characterization of cell death signaling by mercaptopyridine oxide and its analogs in human tumor cells-evidence for p53-independent growth arrest: 470 POSTER. European Journal of Cancer. Supplement, 4(12), 144. https://doi.org/10.1016/S1359-6349(06)70475-X