Mode of Delivery and Risk of Inflammatory Bowel Disease in the Offspring

Systematic Review and Meta-analysis of Observational Studies

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: The incidence of inflammatory bowel disease (IBD) is increasing worldwide; however, pathogenesis is not fully understood. The global cesarean section (CS) rate is also rising, and evidence suggests that mode of delivery may influence colonization of the offspring gut microbiota, predisposing offspring to IBD. This study aimed to investigate the relationship between mode of delivery and risk of IBD.

Methods: The electronic databases, Embase, CINAHL, and Medline (1948 to present) were searched, reference lists were checked, and no restrictions were assigned. Full texts of potentially relevant articles were evaluated, and included articles were assessed for quality. Raw data were used to calculate
unadjusted odds ratios reflecting the risk of developing IBD in those delivered by cesarean. A meta-analysis was performed using RevMan 5 software to obtain a pooled measure of effect. Sensitivity analyses were performed to identify results according to specific study designs.

Results: Seven eligible studies were included; 4 were retrospective cohort design and 3 were case-control studies. The total number of children born by CS in the meta-analysis was 1354, and 11,355 were delivered vaginally. The proportion of IBD in the CS group was 0.249% compared with 0.322% in the vaginal delivery group. The pooled odds ratio of developing IBD when delivered by CS was 1.00 (95% confidence interval, 0.75–1.33).

Conclusions: This analysis observed no significant difference in risk of IBD in offspring delivered by CS compared with those born vaginally
Original languageEnglish
Pages (from-to)1217–1226
Number of pages10
JournalInflammatory Bowel Diseases
Volume20
Issue number7
DOIs
Publication statusPublished - Jul 2014

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Inflammatory Bowel Diseases
Observational Studies
Meta-Analysis
Cesarean Section
Odds Ratio
Case-Control Studies
Software
Databases
Confidence Intervals
Incidence

Keywords

  • Crohn's Disease
  • Ulcerative colitis
  • Epidemiology

Cite this

@article{eb1b4ce618f24aeaa2e131973152670d,
title = "Mode of Delivery and Risk of Inflammatory Bowel Disease in the Offspring: Systematic Review and Meta-analysis of Observational Studies",
abstract = "Background: The incidence of inflammatory bowel disease (IBD) is increasing worldwide; however, pathogenesis is not fully understood. The global cesarean section (CS) rate is also rising, and evidence suggests that mode of delivery may influence colonization of the offspring gut microbiota, predisposing offspring to IBD. This study aimed to investigate the relationship between mode of delivery and risk of IBD. Methods: The electronic databases, Embase, CINAHL, and Medline (1948 to present) were searched, reference lists were checked, and no restrictions were assigned. Full texts of potentially relevant articles were evaluated, and included articles were assessed for quality. Raw data were used to calculateunadjusted odds ratios reflecting the risk of developing IBD in those delivered by cesarean. A meta-analysis was performed using RevMan 5 software to obtain a pooled measure of effect. Sensitivity analyses were performed to identify results according to specific study designs.Results: Seven eligible studies were included; 4 were retrospective cohort design and 3 were case-control studies. The total number of children born by CS in the meta-analysis was 1354, and 11,355 were delivered vaginally. The proportion of IBD in the CS group was 0.249{\%} compared with 0.322{\%} in the vaginal delivery group. The pooled odds ratio of developing IBD when delivered by CS was 1.00 (95{\%} confidence interval, 0.75–1.33). Conclusions: This analysis observed no significant difference in risk of IBD in offspring delivered by CS compared with those born vaginally",
keywords = "Crohn's Disease, Ulcerative colitis, Epidemiology",
author = "Alanna Bruce and Black, {Mairead Eileen} and Sohinee Bhattacharya",
year = "2014",
month = "7",
doi = "10.1097/MIB.0000000000000075",
language = "English",
volume = "20",
pages = "1217–1226",
journal = "Inflammatory Bowel Diseases",
issn = "1078-0998",
publisher = "John Wiley and Sons Inc.",
number = "7",

}

TY - JOUR

T1 - Mode of Delivery and Risk of Inflammatory Bowel Disease in the Offspring

T2 - Systematic Review and Meta-analysis of Observational Studies

AU - Bruce, Alanna

AU - Black, Mairead Eileen

AU - Bhattacharya, Sohinee

PY - 2014/7

Y1 - 2014/7

N2 - Background: The incidence of inflammatory bowel disease (IBD) is increasing worldwide; however, pathogenesis is not fully understood. The global cesarean section (CS) rate is also rising, and evidence suggests that mode of delivery may influence colonization of the offspring gut microbiota, predisposing offspring to IBD. This study aimed to investigate the relationship between mode of delivery and risk of IBD. Methods: The electronic databases, Embase, CINAHL, and Medline (1948 to present) were searched, reference lists were checked, and no restrictions were assigned. Full texts of potentially relevant articles were evaluated, and included articles were assessed for quality. Raw data were used to calculateunadjusted odds ratios reflecting the risk of developing IBD in those delivered by cesarean. A meta-analysis was performed using RevMan 5 software to obtain a pooled measure of effect. Sensitivity analyses were performed to identify results according to specific study designs.Results: Seven eligible studies were included; 4 were retrospective cohort design and 3 were case-control studies. The total number of children born by CS in the meta-analysis was 1354, and 11,355 were delivered vaginally. The proportion of IBD in the CS group was 0.249% compared with 0.322% in the vaginal delivery group. The pooled odds ratio of developing IBD when delivered by CS was 1.00 (95% confidence interval, 0.75–1.33). Conclusions: This analysis observed no significant difference in risk of IBD in offspring delivered by CS compared with those born vaginally

AB - Background: The incidence of inflammatory bowel disease (IBD) is increasing worldwide; however, pathogenesis is not fully understood. The global cesarean section (CS) rate is also rising, and evidence suggests that mode of delivery may influence colonization of the offspring gut microbiota, predisposing offspring to IBD. This study aimed to investigate the relationship between mode of delivery and risk of IBD. Methods: The electronic databases, Embase, CINAHL, and Medline (1948 to present) were searched, reference lists were checked, and no restrictions were assigned. Full texts of potentially relevant articles were evaluated, and included articles were assessed for quality. Raw data were used to calculateunadjusted odds ratios reflecting the risk of developing IBD in those delivered by cesarean. A meta-analysis was performed using RevMan 5 software to obtain a pooled measure of effect. Sensitivity analyses were performed to identify results according to specific study designs.Results: Seven eligible studies were included; 4 were retrospective cohort design and 3 were case-control studies. The total number of children born by CS in the meta-analysis was 1354, and 11,355 were delivered vaginally. The proportion of IBD in the CS group was 0.249% compared with 0.322% in the vaginal delivery group. The pooled odds ratio of developing IBD when delivered by CS was 1.00 (95% confidence interval, 0.75–1.33). Conclusions: This analysis observed no significant difference in risk of IBD in offspring delivered by CS compared with those born vaginally

KW - Crohn's Disease

KW - Ulcerative colitis

KW - Epidemiology

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SN - 1078-0998

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