Activated factor XIII (FXIIIa), a transglutaminase, introduces fibrin-fibrin and fibrin-inhibitor cross-links, resulting in more mechanically stable clots. The impact of cross-linking on resistance to fibrinolysis has proved challenging to evaluate quantitatively.
- factor XIII
Mutch, N. J., Koikkalainen, J. S., Fraser, S. R., Duthie, K. M., Griffin, M., Mitchell, J., Watson, H. G., & Booth, N. A. (2010). Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis. Journal of Thrombosis and Haemostasis, 8(9), 2017-2024. https://doi.org/10.1111/j.1538-7836.2010.03963.x