Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis

Nicola Jane Mutch, J S Koikkalainen, S R Fraser, K M Duthie, M Griffin, Jennifer Mitchell, H G Watson, N A Booth

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Activated factor XIII (FXIIIa), a transglutaminase, introduces fibrin-fibrin and fibrin-inhibitor cross-links, resulting in more mechanically stable clots. The impact of cross-linking on resistance to fibrinolysis has proved challenging to evaluate quantitatively.
Original languageEnglish
Pages (from-to)2017-2024
Number of pages8
JournalJournal of Thrombosis and Haemostasis
Volume8
Issue number9
Early online date24 Jun 2010
DOIs
Publication statusPublished - 1 Sep 2010

Keywords

  • factor XIII
  • fibrinolysis
  • flow
  • stability
  • thrombi

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