Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis

Nicola Jane Mutch, J S Koikkalainen, S R Fraser, K M Duthie, M Griffin, Jennifer Mitchell, H G Watson, N A Booth

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Activated factor XIII (FXIIIa), a transglutaminase, introduces fibrin-fibrin and fibrin-inhibitor cross-links, resulting in more mechanically stable clots. The impact of cross-linking on resistance to fibrinolysis has proved challenging to evaluate quantitatively.
Original languageEnglish
Pages (from-to)2017-2024
Number of pages8
JournalJournal of Thrombosis and Haemostasis
Volume8
Issue number9
Early online date24 Jun 2010
DOIs
Publication statusPublished - 1 Sep 2010

Fingerprint

Fibrinolysis
Fibrin
Thrombosis
Factor XIIIa
Transglutaminases

Keywords

  • factor XIII
  • fibrinolysis
  • flow
  • stability
  • thrombi

Cite this

Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis. / Mutch, Nicola Jane; Koikkalainen, J S; Fraser, S R; Duthie, K M; Griffin, M; Mitchell, Jennifer; Watson, H G; Booth, N A.

In: Journal of Thrombosis and Haemostasis, Vol. 8, No. 9, 01.09.2010, p. 2017-2024.

Research output: Contribution to journalArticle

Mutch, Nicola Jane ; Koikkalainen, J S ; Fraser, S R ; Duthie, K M ; Griffin, M ; Mitchell, Jennifer ; Watson, H G ; Booth, N A. / Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis. In: Journal of Thrombosis and Haemostasis. 2010 ; Vol. 8, No. 9. pp. 2017-2024.
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AU - Duthie, K M

AU - Griffin, M

AU - Mitchell, Jennifer

AU - Watson, H G

AU - Booth, N A

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