Modeling CRISPR gene drives for suppression of invasive rodents using a supervised machine learning framework

Samuel E. Champer, Nathan Oakes, Ronin Sharma, Pablo Garcia Diaz, Jackson Champer, Philipp W Messer* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)
1 Downloads (Pure)


Invasive rodent populations pose a threat to biodiversity across the globe. When confronted with these invaders, native species that evolved independently are often defenseless. CRISPR gene drive systems could provide a solution to this problem by spreading transgenes among invaders that induce population collapse, and could be deployed even where traditional control methods are impractical or prohibitively expensive. Here, we develop a high-fidelity model of an island population of invasive rodents that includes three types of suppression gene drive systems. The individual-based model is spatially explicit, allows for overlapping generations and a fluctuating population size, and includes variables for drive fitness, efficiency, resistance allele formation rate, as well as a variety of ecological parameters. The computational burden of evaluating a
model with such a high number of parameters presents a substantial barrier to a comprehensive understanding of its outcome space. We therefore accompany our population model with a meta13 model that utilizes supervised machine learning to approximate the outcome space of the underlying model with a high degree of accuracy. This enables us to conduct an exhaustive inquiry of the population model, including variance-based sensitivity analyses using tens of
millions of evaluations. Our results suggest that sufficiently capable gene drive systems have the potential to eliminate island populations of rodents under a wide range of demographic assumptions, though only if resistance can be kept to a minimal level. This study highlights the power of supervised machine learning to identify the key parameters and processes that determine the population dynamics of a complex evolutionary system.
Original languageEnglish
Article numbere1009660
Number of pages37
JournalPLoS Computational Biology
Issue number12
Early online date21 Dec 2021
Publication statusPublished - 29 Dec 2021


Dive into the research topics of 'Modeling CRISPR gene drives for suppression of invasive rodents using a supervised machine learning framework'. Together they form a unique fingerprint.

Cite this