Modelling corneal epithelial wound closure in the presence of physiological electric fields via a moving boundary formalism

E A Gaffney, P K Maini, C D McCaig, M Zhao, J V Forrester

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A new framework for the modelling of corneal epithelial wound healing is presented, which can include the presence of a physiological electric field. The difficulty inherent in the inclusion of this biological phenomenon motivates our use of a moving boundary formalism. A key conclusion is that the model predicts a linear relation between the wound healing speed and the physiological electric field strengths over a physiologically large range of electric field strength. Another key point is that this linear relationship between electric field strength and wound healing speed is robust to variations in critical parameters that are difficult to estimate. The linearity is also robust to different realizations of the modelling framework presented.

Original languageEnglish
Pages (from-to)369-393
Number of pages25
JournalIMA Journal of Mathematics Applied in Medicine and Biology
Volume16
Publication statusPublished - 1999

Keywords

  • moving boundaries
  • corneal epithelial wound healing
  • EPIDERMAL GROWTH-FACTOR
  • CELL-MIGRATION
  • DIFFERENTIATION
  • EYE

Cite this

Modelling corneal epithelial wound closure in the presence of physiological electric fields via a moving boundary formalism. / Gaffney, E A ; Maini, P K ; McCaig, C D ; Zhao, M ; Forrester, J V .

In: IMA Journal of Mathematics Applied in Medicine and Biology, Vol. 16, 1999, p. 369-393.

Research output: Contribution to journalArticle

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