Modelling magnetic carrier particle targeting in the tumor
   microvasculature for cancer treatment

Ovidiu Rotariu; Norval James Colin Strachan

doi:10.1016/j.jmmm.2005.01.081

Modelling magnetic carrier particle targeting in the tumor microvasculature for cancer treatment

Ovidiu Rotariu, Norval James Colin Strachan

Physics

Research output: Contribution to journal › Article › peer-review

99 Citations (Scopus)

Abstract

Magnetic drug targeting of tumors situated in the cavity of the human body is difficult because the magnetic gradients decrease rapidly with the distance from the magnets. Here computer simulations are used to investigate different techniques to focus small MPs within the microvasculature of tumors. Non-invasive methods were found to have range < 15 cm whilst minimal invasive methods could be applied specifically to small tumors (< 18 mm). (c) 2005 Published by Elsevier B.V.

Original language	English
Pages (from-to)	639-646
Number of pages	7
Journal	Journal of Magnetism and Magnetic Materials
Volume	293
Issue number	1
DOIs	https://doi.org/10.1016/j.jmmm.2005.01.081
Publication status	Published - May 2005

Keywords

magnetic drug targeting
magnetic particles
blood flow
arterioles
capillaries
mathematical modeling
simulation
tumor physiology
magnetic focusing
magnetic needle
MAGNETORHEOLOGICAL FLUIDS
SOLID TUMORS
BLOOD-FLOW

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jmmm.2005.01.081

Cite this

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title = "Modelling magnetic carrier particle targeting in the tumor microvasculature for cancer treatment",

abstract = "Magnetic drug targeting of tumors situated in the cavity of the human body is difficult because the magnetic gradients decrease rapidly with the distance from the magnets. Here computer simulations are used to investigate different techniques to focus small MPs within the microvasculature of tumors. Non-invasive methods were found to have range < 15 cm whilst minimal invasive methods could be applied specifically to small tumors (< 18 mm). (c) 2005 Published by Elsevier B.V.",

keywords = "magnetic drug targeting, magnetic particles, blood flow, arterioles, capillaries, mathematical modeling, simulation, tumor physiology, magnetic focusing, magnetic needle, MAGNETORHEOLOGICAL FLUIDS, SOLID TUMORS, BLOOD-FLOW",

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KW - magnetic drug targeting

KW - magnetic particles

KW - blood flow

KW - arterioles

KW - capillaries

KW - mathematical modeling

KW - simulation

KW - tumor physiology

KW - magnetic focusing

KW - magnetic needle

KW - MAGNETORHEOLOGICAL FLUIDS

KW - SOLID TUMORS

KW - BLOOD-FLOW

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DO - 10.1016/j.jmmm.2005.01.081

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