Modelling magnetic carrier particle targeting in the tumor microvasculature for cancer treatment

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Abstract

Magnetic drug targeting of tumors situated in the cavity of the human body is difficult because the magnetic gradients decrease rapidly with the distance from the magnets. Here computer simulations are used to investigate different techniques to focus small MPs within the microvasculature of tumors. Non-invasive methods were found to have range < 15 cm whilst minimal invasive methods could be applied specifically to small tumors (< 18 mm). (c) 2005 Published by Elsevier B.V.

Original languageEnglish
Pages (from-to)639-646
Number of pages7
JournalJournal of Magnetism and Magnetic Materials
Volume293
Issue number1
DOIs
Publication statusPublished - May 2005

Keywords

  • magnetic drug targeting
  • magnetic particles
  • blood flow
  • arterioles
  • capillaries
  • mathematical modeling
  • simulation
  • tumor physiology
  • magnetic focusing
  • magnetic needle
  • MAGNETORHEOLOGICAL FLUIDS
  • SOLID TUMORS
  • BLOOD-FLOW

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