Modes of salmonid MHC class I and II evolution differ from the primate paradigm

B. P. Shum, L. Guethlein, L. R. Flodin, M. A. Adkison, R. P. Hedrick, R. J. M. Stet, R. B. Nehring, Christopher John Secombes

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Rainbow trout (Oncorhynchus mykiss) and brown trout (Salmo trutta) represent two salmonid genera separated for 15-20 million years. cDNA sequences were determined for the classical MHC class I heavy chain gene UBA and the MHC class LT beta -chain gene DAB from 15 rainbow and 10 brown trout. Both genes are highly polymorphic in both species and diploid in expression. The MHC class I alleles comprise several highly divergent lineages that are represented in both species and predate genera separation. The class II alleles are less divergent, highly species specific, and probably arose after genera separation, The striking difference in salmonid MHC class I and class LI evolution contrasts with the situation in primates, where lineages of class II alleles have been sustained over longer periods of time relative to class I lineages, The difference may arise because salmonid MHC class I and II genes are not linked, whereas in mammals they are closely linked, A prevalent mechanism for evolving new MHC class I alleles in salmonids is recombination in intron II that shuffles alpha1 and alpha2 domains into different combinations.

Original languageEnglish
Pages (from-to)3297-3308
Number of pages11
JournalThe Journal of Immunology
Volume166
Publication statusPublished - 2001

Keywords

  • MAJOR HISTOCOMPATIBILITY COMPLEX
  • TROUT ONCORHYNCHUS-MYKISS
  • RAINBOW-TROUT
  • PACIFIC SALMON
  • BETA-CHAIN
  • GENES
  • SEQUENCE
  • VERTEBRATES
  • IDENTIFICATION
  • CONSERVATION

Cite this

Shum, B. P., Guethlein, L., Flodin, L. R., Adkison, M. A., Hedrick, R. P., Stet, R. J. M., ... Secombes, C. J. (2001). Modes of salmonid MHC class I and II evolution differ from the primate paradigm. The Journal of Immunology, 166, 3297-3308.

Modes of salmonid MHC class I and II evolution differ from the primate paradigm. / Shum, B. P.; Guethlein, L.; Flodin, L. R.; Adkison, M. A.; Hedrick, R. P.; Stet, R. J. M.; Nehring, R. B.; Secombes, Christopher John.

In: The Journal of Immunology, Vol. 166, 2001, p. 3297-3308.

Research output: Contribution to journalArticle

Shum, BP, Guethlein, L, Flodin, LR, Adkison, MA, Hedrick, RP, Stet, RJM, Nehring, RB & Secombes, CJ 2001, 'Modes of salmonid MHC class I and II evolution differ from the primate paradigm', The Journal of Immunology, vol. 166, pp. 3297-3308.
Shum BP, Guethlein L, Flodin LR, Adkison MA, Hedrick RP, Stet RJM et al. Modes of salmonid MHC class I and II evolution differ from the primate paradigm. The Journal of Immunology. 2001;166:3297-3308.
Shum, B. P. ; Guethlein, L. ; Flodin, L. R. ; Adkison, M. A. ; Hedrick, R. P. ; Stet, R. J. M. ; Nehring, R. B. ; Secombes, Christopher John. / Modes of salmonid MHC class I and II evolution differ from the primate paradigm. In: The Journal of Immunology. 2001 ; Vol. 166. pp. 3297-3308.
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abstract = "Rainbow trout (Oncorhynchus mykiss) and brown trout (Salmo trutta) represent two salmonid genera separated for 15-20 million years. cDNA sequences were determined for the classical MHC class I heavy chain gene UBA and the MHC class LT beta -chain gene DAB from 15 rainbow and 10 brown trout. Both genes are highly polymorphic in both species and diploid in expression. The MHC class I alleles comprise several highly divergent lineages that are represented in both species and predate genera separation. The class II alleles are less divergent, highly species specific, and probably arose after genera separation, The striking difference in salmonid MHC class I and class LI evolution contrasts with the situation in primates, where lineages of class II alleles have been sustained over longer periods of time relative to class I lineages, The difference may arise because salmonid MHC class I and II genes are not linked, whereas in mammals they are closely linked, A prevalent mechanism for evolving new MHC class I alleles in salmonids is recombination in intron II that shuffles alpha1 and alpha2 domains into different combinations.",
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AU - Shum, B. P.

AU - Guethlein, L.

AU - Flodin, L. R.

AU - Adkison, M. A.

AU - Hedrick, R. P.

AU - Stet, R. J. M.

AU - Nehring, R. B.

AU - Secombes, Christopher John

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AB - Rainbow trout (Oncorhynchus mykiss) and brown trout (Salmo trutta) represent two salmonid genera separated for 15-20 million years. cDNA sequences were determined for the classical MHC class I heavy chain gene UBA and the MHC class LT beta -chain gene DAB from 15 rainbow and 10 brown trout. Both genes are highly polymorphic in both species and diploid in expression. The MHC class I alleles comprise several highly divergent lineages that are represented in both species and predate genera separation. The class II alleles are less divergent, highly species specific, and probably arose after genera separation, The striking difference in salmonid MHC class I and class LI evolution contrasts with the situation in primates, where lineages of class II alleles have been sustained over longer periods of time relative to class I lineages, The difference may arise because salmonid MHC class I and II genes are not linked, whereas in mammals they are closely linked, A prevalent mechanism for evolving new MHC class I alleles in salmonids is recombination in intron II that shuffles alpha1 and alpha2 domains into different combinations.

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KW - SEQUENCE

KW - VERTEBRATES

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KW - CONSERVATION

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EP - 3308

JO - The Journal of Immunology

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