Abstract
Vitamin D has anticarcinogenic properties and might influence colorectal cancer (CRC) risk, but the epidemiological evidence is inconsistent. Many mechanisms of action for vitamin D have been proposed, with some of them initiating via its binding to the vitamin D receptor (VDR). Using a large Scottish case-control study, we investigated (i) main associations between CRC, vitamin D and calcium dietary intake and 4 VDR single nucleotide polymorphisms (rs10735810, rs1544410, rs11568820, rs7975232) and (ii) interaction associations between the VDR variants, vitamin D and calcium intakes. Inverse and dose-dependent associations were found between CRC risk, dietary [Odds ratio (OR) = 0.77, 95% confidence intervals (CI) 0.63, 6.92, p-trend = 0.012] and total vitamin D (OR = 0.80, 95% CI 0.65, 0.98, p-trend = 0.014) intake in multivariable-adjusted logistic regression models, whereas neither calcium intake nor any of the VDR variants were associated with CRC. Additionally, we observed statistically significant interactions (case-control, case-only designs) between vitamin D and calcium intake and rs10735810 (p-interaction 0.02, 0.006, respectively). We conducted meta-analyses of cohort, case-control and serum studies that also showed an inverse association between dietary vitamin D intake and CRC (serum studies: combined OR 0.76, 95% CI 0.56, 0.87). The evidence of interaction we report here further supports the inverse association between vitamin D mediated through binding to the VDR. (c) 2008 Wiley-Liss, Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 2170-2179 |
| Number of pages | 10 |
| Journal | International Journal of Cancer |
| Volume | 123 |
| Issue number | 9 |
| Early online date | 15 Aug 2008 |
| DOIs | |
| Publication status | Published - 1 Nov 2008 |
Keywords
- colorectal neoplasms
- case-control studies
- single nucleotide polymorphism
- vitamin D
- vitamin D receptor
- receptor gene polymorphisms
- colon-cancer
- rectal-cancer
- dairy-products
- United-States
- prospective cohort
- D metabolites
- Finnish men
- calcium
- women
Cite this
Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding. / Theodoratou, Evropi; Farrington, Susan M.; Tenesa, Albert; McNeill, Geraldine; Cetnarskyj, Roseanne; Barnetson, Rebecca A.; Porteous, Mary E.; Dunlop, Malcolm G.; Campbell, Harry.
In: International Journal of Cancer, Vol. 123, No. 9, 01.11.2008, p. 2170-2179.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding
AU - Theodoratou, Evropi
AU - Farrington, Susan M.
AU - Tenesa, Albert
AU - McNeill, Geraldine
AU - Cetnarskyj, Roseanne
AU - Barnetson, Rebecca A.
AU - Porteous, Mary E.
AU - Dunlop, Malcolm G.
AU - Campbell, Harry
PY - 2008/11/1
Y1 - 2008/11/1
N2 - Vitamin D has anticarcinogenic properties and might influence colorectal cancer (CRC) risk, but the epidemiological evidence is inconsistent. Many mechanisms of action for vitamin D have been proposed, with some of them initiating via its binding to the vitamin D receptor (VDR). Using a large Scottish case-control study, we investigated (i) main associations between CRC, vitamin D and calcium dietary intake and 4 VDR single nucleotide polymorphisms (rs10735810, rs1544410, rs11568820, rs7975232) and (ii) interaction associations between the VDR variants, vitamin D and calcium intakes. Inverse and dose-dependent associations were found between CRC risk, dietary [Odds ratio (OR) = 0.77, 95% confidence intervals (CI) 0.63, 6.92, p-trend = 0.012] and total vitamin D (OR = 0.80, 95% CI 0.65, 0.98, p-trend = 0.014) intake in multivariable-adjusted logistic regression models, whereas neither calcium intake nor any of the VDR variants were associated with CRC. Additionally, we observed statistically significant interactions (case-control, case-only designs) between vitamin D and calcium intake and rs10735810 (p-interaction 0.02, 0.006, respectively). We conducted meta-analyses of cohort, case-control and serum studies that also showed an inverse association between dietary vitamin D intake and CRC (serum studies: combined OR 0.76, 95% CI 0.56, 0.87). The evidence of interaction we report here further supports the inverse association between vitamin D mediated through binding to the VDR. (c) 2008 Wiley-Liss, Inc.
AB - Vitamin D has anticarcinogenic properties and might influence colorectal cancer (CRC) risk, but the epidemiological evidence is inconsistent. Many mechanisms of action for vitamin D have been proposed, with some of them initiating via its binding to the vitamin D receptor (VDR). Using a large Scottish case-control study, we investigated (i) main associations between CRC, vitamin D and calcium dietary intake and 4 VDR single nucleotide polymorphisms (rs10735810, rs1544410, rs11568820, rs7975232) and (ii) interaction associations between the VDR variants, vitamin D and calcium intakes. Inverse and dose-dependent associations were found between CRC risk, dietary [Odds ratio (OR) = 0.77, 95% confidence intervals (CI) 0.63, 6.92, p-trend = 0.012] and total vitamin D (OR = 0.80, 95% CI 0.65, 0.98, p-trend = 0.014) intake in multivariable-adjusted logistic regression models, whereas neither calcium intake nor any of the VDR variants were associated with CRC. Additionally, we observed statistically significant interactions (case-control, case-only designs) between vitamin D and calcium intake and rs10735810 (p-interaction 0.02, 0.006, respectively). We conducted meta-analyses of cohort, case-control and serum studies that also showed an inverse association between dietary vitamin D intake and CRC (serum studies: combined OR 0.76, 95% CI 0.56, 0.87). The evidence of interaction we report here further supports the inverse association between vitamin D mediated through binding to the VDR. (c) 2008 Wiley-Liss, Inc.
KW - colorectal neoplasms
KW - case-control studies
KW - single nucleotide polymorphism
KW - vitamin D
KW - vitamin D receptor
KW - receptor gene polymorphisms
KW - colon-cancer
KW - rectal-cancer
KW - dairy-products
KW - United-States
KW - prospective cohort
KW - D metabolites
KW - Finnish men
KW - calcium
KW - women
U2 - 10.1002/ijc.23769
DO - 10.1002/ijc.23769
M3 - Article
VL - 123
SP - 2170
EP - 2179
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 9
ER -