Modulation of Fasted and Postprandial Plasma Lipids in Healthy Volunteers by a Dietary Mixture of Omega-3 Fatty Acids and Conjugated Linoleic Acid

Fotini Tsofliou, Claire Fyfe, Ian Matheson, Diane Jackson, Graham W Horgan, Klaus Wilfried Juergen Wahle, Bo Ahren, Lynda Williams, Alan Arthur Sneddon

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Effects of a dietary combination of omega-3 polyunsaturated fatty acids (n-3-PUFA) and conjugated linoleic acids (CLAs) on fasting and postprandial plasma lipids was investigated in healthy volunteers with different ages and body mass index (BMI). Lean (BMI 20-26 kg/m2) and obese (BMI 29-35 kg/m2), young (20-37 years) and older (50-65 years) men consumed 3 g/day each of CLA and n-3-PUFA or 6 g/day control oil for 12 weeks in a double-blinded, placebo-controlled, randomized crossover study. In older lean subjects, CLA/n-3-PUFA supplementation reduced fasting nonesterified fatty acids (NEFAs) concentrations compared with the control oil (P < 0.05). However, in older obese subjects, CLA/n-3-PUFA increased fasting low-density lipoprotein cholesterol (P < 0.05) and postprandial total cholesterol levels (P < 0.05). In young lean subjects, CLA/n-3-PUFA reduced postprandial NEFA levels (P < 0.05) whereas in young obese subjects, postprandial total cholesterol and triacylglycerols were lowered (both P < 0.05). Therefore, a dietary combination of CLA together with n-3-PUFA may have favorable effects on plasma lipids in young and older lean men but detrimental effects in older obese men.

PRACTICAL APPLICATIONS

This study suggests that where individuals consume a combination of both omega-3 polyunsaturated fatty acids and conjugated linoleic acid supplements in order to obtain potential additive beneficial effects of each lipid on adiposity and health, this particular fatty acid combination may have harmful effects on plasma lipid biomarkers of cardiovascular disease in older obese men.

Original languageEnglish
Pages (from-to)499-513
Number of pages15
JournalJournal of Food Lipids
Volume16
Issue number4
DOIs
Publication statusPublished - Nov 2009

Keywords

  • polyunsaturated fatty-acids
  • fish-oil supplementation
  • middle-aged men
  • body-fat
  • insulin sensitivity
  • lipoprotein metabolism
  • overweight humans
  • adipose-tissue
  • serum-lipids
  • obese men
  • fish oil supplementation
  • insulin
  • sensitivity

Cite this

Modulation of Fasted and Postprandial Plasma Lipids in Healthy Volunteers by a Dietary Mixture of Omega-3 Fatty Acids and Conjugated Linoleic Acid. / Tsofliou, Fotini; Fyfe, Claire; Matheson, Ian; Jackson, Diane; Horgan, Graham W; Wahle, Klaus Wilfried Juergen; Ahren, Bo; Williams, Lynda; Sneddon, Alan Arthur.

In: Journal of Food Lipids, Vol. 16, No. 4, 11.2009, p. 499-513.

Research output: Contribution to journalArticle

Tsofliou, Fotini ; Fyfe, Claire ; Matheson, Ian ; Jackson, Diane ; Horgan, Graham W ; Wahle, Klaus Wilfried Juergen ; Ahren, Bo ; Williams, Lynda ; Sneddon, Alan Arthur. / Modulation of Fasted and Postprandial Plasma Lipids in Healthy Volunteers by a Dietary Mixture of Omega-3 Fatty Acids and Conjugated Linoleic Acid. In: Journal of Food Lipids. 2009 ; Vol. 16, No. 4. pp. 499-513.
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abstract = "Effects of a dietary combination of omega-3 polyunsaturated fatty acids (n-3-PUFA) and conjugated linoleic acids (CLAs) on fasting and postprandial plasma lipids was investigated in healthy volunteers with different ages and body mass index (BMI). Lean (BMI 20-26 kg/m2) and obese (BMI 29-35 kg/m2), young (20-37 years) and older (50-65 years) men consumed 3 g/day each of CLA and n-3-PUFA or 6 g/day control oil for 12 weeks in a double-blinded, placebo-controlled, randomized crossover study. In older lean subjects, CLA/n-3-PUFA supplementation reduced fasting nonesterified fatty acids (NEFAs) concentrations compared with the control oil (P < 0.05). However, in older obese subjects, CLA/n-3-PUFA increased fasting low-density lipoprotein cholesterol (P < 0.05) and postprandial total cholesterol levels (P < 0.05). In young lean subjects, CLA/n-3-PUFA reduced postprandial NEFA levels (P < 0.05) whereas in young obese subjects, postprandial total cholesterol and triacylglycerols were lowered (both P < 0.05). Therefore, a dietary combination of CLA together with n-3-PUFA may have favorable effects on plasma lipids in young and older lean men but detrimental effects in older obese men.PRACTICAL APPLICATIONSThis study suggests that where individuals consume a combination of both omega-3 polyunsaturated fatty acids and conjugated linoleic acid supplements in order to obtain potential additive beneficial effects of each lipid on adiposity and health, this particular fatty acid combination may have harmful effects on plasma lipid biomarkers of cardiovascular disease in older obese men.",
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T1 - Modulation of Fasted and Postprandial Plasma Lipids in Healthy Volunteers by a Dietary Mixture of Omega-3 Fatty Acids and Conjugated Linoleic Acid

AU - Tsofliou, Fotini

AU - Fyfe, Claire

AU - Matheson, Ian

AU - Jackson, Diane

AU - Horgan, Graham W

AU - Wahle, Klaus Wilfried Juergen

AU - Ahren, Bo

AU - Williams, Lynda

AU - Sneddon, Alan Arthur

PY - 2009/11

Y1 - 2009/11

N2 - Effects of a dietary combination of omega-3 polyunsaturated fatty acids (n-3-PUFA) and conjugated linoleic acids (CLAs) on fasting and postprandial plasma lipids was investigated in healthy volunteers with different ages and body mass index (BMI). Lean (BMI 20-26 kg/m2) and obese (BMI 29-35 kg/m2), young (20-37 years) and older (50-65 years) men consumed 3 g/day each of CLA and n-3-PUFA or 6 g/day control oil for 12 weeks in a double-blinded, placebo-controlled, randomized crossover study. In older lean subjects, CLA/n-3-PUFA supplementation reduced fasting nonesterified fatty acids (NEFAs) concentrations compared with the control oil (P < 0.05). However, in older obese subjects, CLA/n-3-PUFA increased fasting low-density lipoprotein cholesterol (P < 0.05) and postprandial total cholesterol levels (P < 0.05). In young lean subjects, CLA/n-3-PUFA reduced postprandial NEFA levels (P < 0.05) whereas in young obese subjects, postprandial total cholesterol and triacylglycerols were lowered (both P < 0.05). Therefore, a dietary combination of CLA together with n-3-PUFA may have favorable effects on plasma lipids in young and older lean men but detrimental effects in older obese men.PRACTICAL APPLICATIONSThis study suggests that where individuals consume a combination of both omega-3 polyunsaturated fatty acids and conjugated linoleic acid supplements in order to obtain potential additive beneficial effects of each lipid on adiposity and health, this particular fatty acid combination may have harmful effects on plasma lipid biomarkers of cardiovascular disease in older obese men.

AB - Effects of a dietary combination of omega-3 polyunsaturated fatty acids (n-3-PUFA) and conjugated linoleic acids (CLAs) on fasting and postprandial plasma lipids was investigated in healthy volunteers with different ages and body mass index (BMI). Lean (BMI 20-26 kg/m2) and obese (BMI 29-35 kg/m2), young (20-37 years) and older (50-65 years) men consumed 3 g/day each of CLA and n-3-PUFA or 6 g/day control oil for 12 weeks in a double-blinded, placebo-controlled, randomized crossover study. In older lean subjects, CLA/n-3-PUFA supplementation reduced fasting nonesterified fatty acids (NEFAs) concentrations compared with the control oil (P < 0.05). However, in older obese subjects, CLA/n-3-PUFA increased fasting low-density lipoprotein cholesterol (P < 0.05) and postprandial total cholesterol levels (P < 0.05). In young lean subjects, CLA/n-3-PUFA reduced postprandial NEFA levels (P < 0.05) whereas in young obese subjects, postprandial total cholesterol and triacylglycerols were lowered (both P < 0.05). Therefore, a dietary combination of CLA together with n-3-PUFA may have favorable effects on plasma lipids in young and older lean men but detrimental effects in older obese men.PRACTICAL APPLICATIONSThis study suggests that where individuals consume a combination of both omega-3 polyunsaturated fatty acids and conjugated linoleic acid supplements in order to obtain potential additive beneficial effects of each lipid on adiposity and health, this particular fatty acid combination may have harmful effects on plasma lipid biomarkers of cardiovascular disease in older obese men.

KW - polyunsaturated fatty-acids

KW - fish-oil supplementation

KW - middle-aged men

KW - body-fat

KW - insulin sensitivity

KW - lipoprotein metabolism

KW - overweight humans

KW - adipose-tissue

KW - serum-lipids

KW - obese men

KW - fish oil supplementation

KW - insulin

KW - sensitivity

U2 - 10.1111/j.1745-4522.2009.01162.x

DO - 10.1111/j.1745-4522.2009.01162.x

M3 - Article

VL - 16

SP - 499

EP - 513

JO - Journal of Food Lipids

JF - Journal of Food Lipids

SN - 1065-7258

IS - 4

ER -