Molecular genetic contributions to socioeconomic status and intelligence

Riccardo E Marioni, Gail Davies, Caroline Hayward, Dave Liewald, Shona M Kerr, Archie Campbell, Michelle Luciano, Blair H Smith, Sandosh Padmanabhan, Lynne J Hocking, Nicholas D Hastie, Alan F Wright, David J Porteous, Peter M Visscher, Ian J Deary

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Abstract

Education, socioeconomic status, and intelligence are commonly used as predictors of health outcomes, social environment, and mortality. Education and socioeconomic status are typically viewed as environmental variables although both correlate with intelligence, which has a substantial genetic basis. Using data from 6815 unrelated subjects from the Generation Scotland study, we examined the genetic contributions to these variables and their genetic correlations. Subjects underwent genome-wide testing for common single nucleotide polymorphisms (SNPs). DNA-derived heritability estimates and genetic correlations were calculated using the 'Genome-wide Complex Trait Analyses' (GCTA) procedures. 21% of the variation in education, 18% of the variation in socioeconomic status, and 29% of the variation in general cognitive ability was explained by variation in common SNPs (SEs ~ 5%). The SNP-based genetic correlations of education and socioeconomic status with general intelligence were 0.95 (SE 0.13) and 0.26 (0.16), respectively. There are genetic contributions to intelligence and education with near-complete overlap between common additive SNP effects on these traits (genetic correlation ~ 1). Genetic influences on socioeconomic status are also associated with the genetic foundations of intelligence. The results are also compatible with substantial environmental contributions to socioeconomic status.

Original languageEnglish
Pages (from-to)26-32
Number of pages7
JournalIntelligence
Volume44
Issue number100
Early online date14 Mar 2014
DOIs
Publication statusPublished - May 2014

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Intelligence
Social Class
Molecular Biology
Single Nucleotide Polymorphism
Education
Genome
Aptitude
Social Environment
Scotland
Socioeconomic Status
Molecular Genetics
Mortality
DNA
Health
Polymorphism

Keywords

  • Generation Scotland
  • Intelligence
  • Education
  • Socioeconomic status
  • Genetics

Cite this

Marioni, R. E., Davies, G., Hayward, C., Liewald, D., Kerr, S. M., Campbell, A., ... Deary, I. J. (2014). Molecular genetic contributions to socioeconomic status and intelligence. Intelligence, 44(100), 26-32. https://doi.org/10.1016/j.intell.2014.02.006

Molecular genetic contributions to socioeconomic status and intelligence. / Marioni, Riccardo E; Davies, Gail; Hayward, Caroline; Liewald, Dave; Kerr, Shona M; Campbell, Archie; Luciano, Michelle; Smith, Blair H; Padmanabhan, Sandosh; Hocking, Lynne J; Hastie, Nicholas D; Wright, Alan F; Porteous, David J; Visscher, Peter M; Deary, Ian J.

In: Intelligence, Vol. 44, No. 100, 05.2014, p. 26-32.

Research output: Contribution to journalArticle

Marioni, RE, Davies, G, Hayward, C, Liewald, D, Kerr, SM, Campbell, A, Luciano, M, Smith, BH, Padmanabhan, S, Hocking, LJ, Hastie, ND, Wright, AF, Porteous, DJ, Visscher, PM & Deary, IJ 2014, 'Molecular genetic contributions to socioeconomic status and intelligence', Intelligence, vol. 44, no. 100, pp. 26-32. https://doi.org/10.1016/j.intell.2014.02.006
Marioni RE, Davies G, Hayward C, Liewald D, Kerr SM, Campbell A et al. Molecular genetic contributions to socioeconomic status and intelligence. Intelligence. 2014 May;44(100):26-32. https://doi.org/10.1016/j.intell.2014.02.006
Marioni, Riccardo E ; Davies, Gail ; Hayward, Caroline ; Liewald, Dave ; Kerr, Shona M ; Campbell, Archie ; Luciano, Michelle ; Smith, Blair H ; Padmanabhan, Sandosh ; Hocking, Lynne J ; Hastie, Nicholas D ; Wright, Alan F ; Porteous, David J ; Visscher, Peter M ; Deary, Ian J. / Molecular genetic contributions to socioeconomic status and intelligence. In: Intelligence. 2014 ; Vol. 44, No. 100. pp. 26-32.
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