Molecular mechanisms of appetite and obesity: a role for brain AMPK

Pablo B Martínez de Morentin, Adela Urisarri, María L Couce, Miguel López

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Feeding behaviour and energy storage are both crucial aspects of survival. Thus, it is of fundamental importance to understand the molecular mechanisms regulating these basic processes. The AMP-activated protein kinase (AMPK) has been revealed as one of the key molecules modulating energy homoeostasis. Indeed, AMPK appears to be essential for translating nutritional and energy requirements into generation of an adequate neuronal response, particularly in two areas of the brain, the hypothalamus and the hindbrain. Failure of this physiological response can lead to energy imbalance, ultimately with extreme consequences, such as leanness or obesity. Here, we will review the data that put brain AMPK in the spotlight as a regulator of appetite.

Original languageEnglish
Pages (from-to)1697-709
Number of pages13
JournalClinical Science
Volume130
Issue number19
Early online date23 Aug 2016
DOIs
Publication statusPublished - 1 Oct 2016

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Keywords

  • AMPK
  • energy balance
  • food intake
  • hypothalamus
  • obesity

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