Molecular mechanisms of appetite and obesity

a role for brain AMPK

Pablo B Martínez de Morentin, Adela Urisarri, María L Couce, Miguel López

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Feeding behaviour and energy storage are both crucial aspects of survival. Thus, it is of fundamental importance to understand the molecular mechanisms regulating these basic processes. The AMP-activated protein kinase (AMPK) has been revealed as one of the key molecules modulating energy homoeostasis. Indeed, AMPK appears to be essential for translating nutritional and energy requirements into generation of an adequate neuronal response, particularly in two areas of the brain, the hypothalamus and the hindbrain. Failure of this physiological response can lead to energy imbalance, ultimately with extreme consequences, such as leanness or obesity. Here, we will review the data that put brain AMPK in the spotlight as a regulator of appetite.

Original languageEnglish
Pages (from-to)1697-709
Number of pages13
JournalClinical Science
Volume130
Issue number19
DOIs
Publication statusPublished - 1 Oct 2016

Fingerprint

AMP-Activated Protein Kinases
Appetite
Obesity
Brain
Nutritional Requirements
Rhombencephalon
Thinness
Feeding Behavior
Hypothalamus
Homeostasis

Keywords

  • AMPK
  • energy balance
  • food intake
  • hypothalamus
  • obesity

Cite this

Molecular mechanisms of appetite and obesity : a role for brain AMPK. / Martínez de Morentin, Pablo B; Urisarri, Adela; Couce, María L; López, Miguel.

In: Clinical Science, Vol. 130, No. 19, 01.10.2016, p. 1697-709.

Research output: Contribution to journalArticle

Martínez de Morentin, Pablo B ; Urisarri, Adela ; Couce, María L ; López, Miguel. / Molecular mechanisms of appetite and obesity : a role for brain AMPK. In: Clinical Science. 2016 ; Vol. 130, No. 19. pp. 1697-709.
@article{2f686ba6ae204397bd8651294251c92e,
title = "Molecular mechanisms of appetite and obesity: a role for brain AMPK",
abstract = "Feeding behaviour and energy storage are both crucial aspects of survival. Thus, it is of fundamental importance to understand the molecular mechanisms regulating these basic processes. The AMP-activated protein kinase (AMPK) has been revealed as one of the key molecules modulating energy homoeostasis. Indeed, AMPK appears to be essential for translating nutritional and energy requirements into generation of an adequate neuronal response, particularly in two areas of the brain, the hypothalamus and the hindbrain. Failure of this physiological response can lead to energy imbalance, ultimately with extreme consequences, such as leanness or obesity. Here, we will review the data that put brain AMPK in the spotlight as a regulator of appetite.",
keywords = "AMPK, energy balance, food intake, hypothalamus, obesity",
author = "{Mart{\'i}nez de Morentin}, {Pablo B} and Adela Urisarri and Couce, {Mar{\'i}a L} and Miguel L{\'o}pez",
note = "This work was supported by the European Community’s Seventh Framework Programme (FP7/2007-2013) the ObERStress project [grant number 281854 (to M.L.)]; Xunta de Galicia [grant number 2015-CP079 (to M.L.)]; the Ministerio de Econom´ıa y Competitividad (MINECO) co-funded by the FEDER Program of EU [grant numbers SAF2015-71026-R and BFU2015-70454-REDT/Adipoplast (to M.L.)]; and the CIBER de Fisiopatolog´ıa de la Obesidad y Nutricion´ is an initiative of ISCIII.",
year = "2016",
month = "10",
day = "1",
doi = "10.1042/CS20160048",
language = "English",
volume = "130",
pages = "1697--709",
journal = "Clinical Science",
issn = "0143-5221",
publisher = "Portland Press Ltd.",
number = "19",

}

TY - JOUR

T1 - Molecular mechanisms of appetite and obesity

T2 - a role for brain AMPK

AU - Martínez de Morentin, Pablo B

AU - Urisarri, Adela

AU - Couce, María L

AU - López, Miguel

N1 - This work was supported by the European Community’s Seventh Framework Programme (FP7/2007-2013) the ObERStress project [grant number 281854 (to M.L.)]; Xunta de Galicia [grant number 2015-CP079 (to M.L.)]; the Ministerio de Econom´ıa y Competitividad (MINECO) co-funded by the FEDER Program of EU [grant numbers SAF2015-71026-R and BFU2015-70454-REDT/Adipoplast (to M.L.)]; and the CIBER de Fisiopatolog´ıa de la Obesidad y Nutricion´ is an initiative of ISCIII.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Feeding behaviour and energy storage are both crucial aspects of survival. Thus, it is of fundamental importance to understand the molecular mechanisms regulating these basic processes. The AMP-activated protein kinase (AMPK) has been revealed as one of the key molecules modulating energy homoeostasis. Indeed, AMPK appears to be essential for translating nutritional and energy requirements into generation of an adequate neuronal response, particularly in two areas of the brain, the hypothalamus and the hindbrain. Failure of this physiological response can lead to energy imbalance, ultimately with extreme consequences, such as leanness or obesity. Here, we will review the data that put brain AMPK in the spotlight as a regulator of appetite.

AB - Feeding behaviour and energy storage are both crucial aspects of survival. Thus, it is of fundamental importance to understand the molecular mechanisms regulating these basic processes. The AMP-activated protein kinase (AMPK) has been revealed as one of the key molecules modulating energy homoeostasis. Indeed, AMPK appears to be essential for translating nutritional and energy requirements into generation of an adequate neuronal response, particularly in two areas of the brain, the hypothalamus and the hindbrain. Failure of this physiological response can lead to energy imbalance, ultimately with extreme consequences, such as leanness or obesity. Here, we will review the data that put brain AMPK in the spotlight as a regulator of appetite.

KW - AMPK

KW - energy balance

KW - food intake

KW - hypothalamus

KW - obesity

U2 - 10.1042/CS20160048

DO - 10.1042/CS20160048

M3 - Article

VL - 130

SP - 1697

EP - 1709

JO - Clinical Science

JF - Clinical Science

SN - 0143-5221

IS - 19

ER -