Molecular phylogenetic analysis of Candida tropicalis isolates by multi-locus sequence typing

Mette D. Jacobsen; Amanda D. Davidson; Shu-Ying Li; Duncan J. Shaw; Neil A. R. Gow; Frank C. Odds

doi:10.1016/j.fgb.2008.03.011

Molecular phylogenetic analysis of Candida tropicalis isolates by multi-locus sequence typing

Mette D. Jacobsen, Amanda D. Davidson, Shu-Ying Li, Duncan J. Shaw, Neil A. R. Gow, Frank C. Odds

Medical Sciences

Aberdeen Fungal Group

Research output: Contribution to journal › Article

19 Citations (Scopus)

Abstract

Multi-locus sequencing data for 242 different isolates of Candida tropicalis generated a dendrogram showing 235 strains assigned to a single large recently evolved group which contained several small clonal clusters. Haplotype analysis of a representative strain subset revealed a high level of recombination events in an otherwise clonal population. Pairs of isolates from single sources showed non-identity attributable to loss of heterozygosity in some genes in a manner similar to that established for C. albicans. (c) 2008 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	1040-1042
Number of pages	3
Journal	Fungal Genetics and Biology
Volume	45
Issue number	6
Early online date	25 Mar 2008
DOIs	https://doi.org/10.1016/j.fgb.2008.03.011
Publication status	Published - Jun 2008

Keywords

Candida tropicalis
MLST
phylogenetics
albicans
genotypes
Eburst

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10.1016/j.fgb.2008.03.011

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title = "Molecular phylogenetic analysis of Candida tropicalis isolates by multi-locus sequence typing",

abstract = "Multi-locus sequencing data for 242 different isolates of Candida tropicalis generated a dendrogram showing 235 strains assigned to a single large recently evolved group which contained several small clonal clusters. Haplotype analysis of a representative strain subset revealed a high level of recombination events in an otherwise clonal population. Pairs of isolates from single sources showed non-identity attributable to loss of heterozygosity in some genes in a manner similar to that established for C. albicans. (c) 2008 Elsevier Inc. All rights reserved.",

keywords = "Candida tropicalis, MLST, phylogenetics, albicans, genotypes, Eburst",

author = "Jacobsen, {Mette D.} and Davidson, {Amanda D.} and Shu-Ying Li and Shaw, {Duncan J.} and Gow, {Neil A. R.} and Odds, {Frank C.}",

year = "2008",

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doi = "10.1016/j.fgb.2008.03.011",

language = "English",

volume = "45",

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journal = "Fungal Genetics and Biology",

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TY - JOUR

T1 - Molecular phylogenetic analysis of Candida tropicalis isolates by multi-locus sequence typing

AU - Jacobsen, Mette D.

AU - Davidson, Amanda D.

AU - Li, Shu-Ying

AU - Shaw, Duncan J.

AU - Gow, Neil A. R.

AU - Odds, Frank C.

PY - 2008/6

Y1 - 2008/6

N2 - Multi-locus sequencing data for 242 different isolates of Candida tropicalis generated a dendrogram showing 235 strains assigned to a single large recently evolved group which contained several small clonal clusters. Haplotype analysis of a representative strain subset revealed a high level of recombination events in an otherwise clonal population. Pairs of isolates from single sources showed non-identity attributable to loss of heterozygosity in some genes in a manner similar to that established for C. albicans. (c) 2008 Elsevier Inc. All rights reserved.

AB - Multi-locus sequencing data for 242 different isolates of Candida tropicalis generated a dendrogram showing 235 strains assigned to a single large recently evolved group which contained several small clonal clusters. Haplotype analysis of a representative strain subset revealed a high level of recombination events in an otherwise clonal population. Pairs of isolates from single sources showed non-identity attributable to loss of heterozygosity in some genes in a manner similar to that established for C. albicans. (c) 2008 Elsevier Inc. All rights reserved.

KW - Candida tropicalis

KW - MLST

KW - phylogenetics

KW - albicans

KW - genotypes

KW - Eburst

U2 - 10.1016/j.fgb.2008.03.011

DO - 10.1016/j.fgb.2008.03.011

M3 - Article

SN - 1087-1845

VL - 45

SP - 1040

EP - 1042

JO - Fungal Genetics and Biology

JF - Fungal Genetics and Biology

IS - 6

ER -

Molecular phylogenetic analysis of Candida tropicalis isolates by multi-locus sequence typing

Abstract

Keywords

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